Summary
Glass-ceramic implants were administered into cavities prepared in rat femoral shaft. Electron microscope examination revealed formation of collagenous rich matrix in the implant-bone interface. Features typical to primary mineralization as well as bone and implant resorption were present in the interface. Primary mineralization was characterized by the occurrence of active forming cells, extracellular matrix vesicles and calcifying calcospheritic structures. Intensive primary mineralization in association with the implants indicates that glass-ceramic may be stimulative to ossification, allowing favourable tissue-implant relationship.
Zusammenfassung
Glaskeramikimplantate wurden in passende Bohrlöcher des Rattenfemurschafts eingesetzt. Die elektronenmikroskopische Untersuchung ergab die Bildung einer kollagenreichen Matrix an der Grenze zwischen Implantat und Knochen. Typische Erscheinungen der primären Mineralisation und der Resorption von Implantat und Knochen wurden an der Implantat-Knochengrenze festgestellt. Die primäre Mineralisation war gekennzeichnet durch aktive knochenbildende Zellen, extrazelluläre Matrixvesikel und kalzifizierende globuläre Strukturen. Die intensive primare Mineralisation in der Umgebung der Implantate spricht dafür, daß die Glaskeramik die Verknöcherung fördern und eine günstige Beziehung zwischen Gewebe und Implantat zustande kommen kann.
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This study was supported in part by a grant from The Government of Israel, The Ministry of Health by grant MT 0250 Ministerium für Forschung und Technologie, Bonn, West Germany, and by E. Leitz Wetzlar GmbH, Wetzlar, West Germany
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Sela, J., Brandes, J., Strunz, V. et al. Primary mineralization and extracellular matrix vesicles in rat bone after administration of glass-ceramic implants. Arch. Orth. Traum. Surg. 98, 237–240 (1981). https://doi.org/10.1007/BF00632982
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DOI: https://doi.org/10.1007/BF00632982