Summary
Skin allografts were transferred between individuals of white Swiss mice. No first set reaction was observed, but a second set reaction which resulted in accelerated rejection of the graft, could be induced by a second graft transplanted 2 weeks after the first. However, the histoincompatibility of the graft which causes the rejection, could be temporarily weakened when a graft had been cultured “in vitro” for at least 6 weeks prior to grafting. Nevertheless, histocompatibility differences between two different species e.g. man and mouse, could not be weakened at all by the tissue culture method.
Zusammenfassung
Haut-(allo)transplantationen bei weißen Mäusen (Inzuchtstämme) zeigten keine “first set”-Reaktion. Eine beschleunigte Transplantatabstoßung (“second set reaction”) konnte jedoch hervorgerufen werden, wenn eine zweite Transplantation im Abstand von 2 Wochen nach der ersten Transplantation durchgeführt wurde.
Die Antigenizität des Transplantates konnte verringert werden, wenn das Transplantat über einen Zeitraum von mindestens 6 Wochenin vitro gezüchtet wurde. Jedoch ließen sich durch diein vitro-Kultur Speciesunterschiede in der Antigenizität (z. B. zwischen Mensch und Maus) nicht verkleinern.
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Janssen de Limpens, A.M.P., Siddiqui, A.H. & Cormane, R.H. Preliminary studies on the prolongation of the survival of mouse skin allografts cultured on a solid medium. Arch. Derm. Res. 252, 187–192 (1975). https://doi.org/10.1007/BF00557918
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DOI: https://doi.org/10.1007/BF00557918