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HPLC methods for therapeutic drug monitoring involving direct serum injection, column switching, and simple mobile phase adjustments

HPLC-Methoden für das Drug-Monitoring mit direkter Seruminjektion, Säulenschaltung und einfacher Umstellung der mobilen Phasen

  • Posters B
  • Toxicological Analysis and Drug Monitoring
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Fresenius' Zeitschrift für analytische Chemie Aims and scope Submit manuscript

Conclusion

The precision and accuracy of the HPLC methods appear to be sufficient for routine drug measurements. They show a good practicability, as mobile phase adjustments are part of the methods and no sample preparation is required. Although homogeneous non-isotopic immunoassays may be preferable for stat analyses, the described HPLC procedure is an attractive alternative for measuring several drugs and metabolites simultaneously in a single specimen. It is to be expected that numerous further drugs (e.g. anticonvulsants, antiarrhythmics) can be measured by this Chromatographic technique under similar conditions.

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References

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Authors and Affiliations

  1. Institut für Klinische Chemie I, Medizinische Hochschule Hannover, D-3000, Hannover 61, Federal Republic of Germany

    Marianne Wrenger, M. Oellerich & E. Raude

  2. Hewlett Packard GmbH, D-7517, Waldbronn, Federal Republic of Germany

    M. Riedmann

Authors
  1. Marianne Wrenger
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  2. M. Oellerich
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  3. E. Raude
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  4. M. Riedmann
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Wrenger, M., Oellerich, M., Raude, E. et al. HPLC methods for therapeutic drug monitoring involving direct serum injection, column switching, and simple mobile phase adjustments. Z. Anal. Chem. 324, 350–351 (1986). https://doi.org/10.1007/BF00487986

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  • DOI: https://doi.org/10.1007/BF00487986

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