Summary
Synthetic alkyl-lysophospholipids (ALPs) inhibit the proliferation of human hypernephromas in vitro. Cells of ten different tumors were incubated with 4 ALPs for periods of more than 24 h. Eight of ten cell lines showed proliferation rates below 1% of the controls after cultivation. One microgram of ALPs per 106 tumor cells was effective, in some experiments a dose response relation was found for even lower concentrations. Equivalent concentrations of cytostatic drugs did not show reproducible higher antitumor effects in vitro. In two of the tested cell lines ALPs did not show any reproducible tumor growth inhibition, whereas at least some of the cytostatic drugs revealed slight cytostatis.
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Supported by the Deutsche Forschungsgemeinschaft, grant no. Be 822/1, and by Freunde der Technischen Universität München e. V.
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Berdel, W.E., Fink, U., Egger, B. et al. Alkyl-lysophospholipids inhibit the growth of hypernephroid carcinomas in vitro. J Cancer Res Clin Oncol 101, 325–330 (1981). https://doi.org/10.1007/BF00410118
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DOI: https://doi.org/10.1007/BF00410118