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PkpA, a novel Phycomyces blakesleeanus serine/threonine protein kinase

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Abstract

This work reports the cloning and sequencing of pkpA, a gene of the filamentous fungus Phycomyces blakesleeanus, whose expression seems to be coupled to vegetative growth. This gene encodes a putative serine/threonine-specific protein kinase, whose sequence is related to that of the yeast protein STE20, involved in pheromone-response pathways, and to a number of MAPK kinase proteins. However, detailed analysis of the kinase sequence suggests that PkpA is a novel serine/threonine protein kinase that probably participates as an intermediate in an intracellular system controlling nuclear proliferation in P. blakesleeanus.

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Authors and Affiliations

  1. Departmento de Genética y Microbiología, Faculted de Biología, Universidad de Murcia, Apdo 4021, E-30071, Murcia, Spain

    Victor L. Ruiz-Pérez, Francisco J. Murillo & Santiago Torres-Martínez

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  1. Victor L. Ruiz-Pérez
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  2. Francisco J. Murillo
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  3. Santiago Torres-Martínez
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Communicated by K. Wolf

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Ruiz-Pérez, V.L., Murillo, F.J. & Torres-Martínez, S. PkpA, a novel Phycomyces blakesleeanus serine/threonine protein kinase. Curr Genet 28, 309–316 (1995). https://doi.org/10.1007/BF00326428

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  • DOI: https://doi.org/10.1007/BF00326428

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