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Cell kinetics of the growth plate in hypophysectomized rats treated with growth hormone and thyroxine

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Summary

The cell production in the growth plate of the proximal tibia was calculated in hypophysectomized rats given growth hormone and/or thyroxine from values of longitudinal bone growth determined with oxytetracycline and the size of degenerative cells in the growth plate.

The changes in longitudinal bone growth induced by thyroxine and growth hormone in hypophysectomized rats were found to be predominantly caused by changes in the cell production, whereas the changes in the size of the degenerative cells were minor. The stimulation of cell production by growth hormone was dependent on the dose and the administration period. Thyroxine was found to stimulate the cell production up to an optimum dose of thyroxine.

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Authors and Affiliations

  1. Departments of Histology and Orthopaedic Surgery, University of Lund, Lund, Sweden

    K. -G. Thorngren & L. I. Hansson

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  1. K. -G. Thorngren
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  2. L. I. Hansson
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Thorngren, K.G., Hansson, L.I. Cell kinetics of the growth plate in hypophysectomized rats treated with growth hormone and thyroxine. Z.Zellforsch 142, 431–442 (1973). https://doi.org/10.1007/BF00307362

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  • DOI: https://doi.org/10.1007/BF00307362

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