Skip to main content
Log in

Cell spreading and motility: A model lamellipod

  • Research Announcement
  • Published:
Journal of Mathematical Biology Aims and scope Submit manuscript

Abstract

Cells moving in vitro do so by means of a motile appendage, the lamellipod. This is a broad, flat sheet of cytogel which spreads in front of the cell and pulls the cell forward. We present here a mathematical model for lamellipodial motion based on the physical chemistry of actomyosin gels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cooper, M., Keller, R.: Perpendicular orientation and directional migration of amphibian neural crest cells in dc electrical fields. Proc. Natl. Acad. Sci. USA 81, 161–164 (1984)

    Google Scholar 

  • De Gennes, P.: Dynamics of entangled polymer solutions I. The Rouse Model. Macromolecules 9, 587–593 (1976)

    Google Scholar 

  • Dembo, M., Harlow, F. J., Alt, W.: The biophysics of cell surface motility. In: Cell Surface Dynamics: Concepts and Models, A. Perelson, C. DeLisi, F. Wiegel, (eds.). New York: Marcel Dekker 1984

    Google Scholar 

  • Flory, P.: Principles of Polymer Chemistry. Itheca, Cornell University Press, 1953.

    Google Scholar 

  • Johnson, D.: Elastodynamics of gels. J. Chem. Phys. 77, 1531–1539 (1982)

    Google Scholar 

  • Korn, E.: Actin polymerization and its regulation by proteins from nonmuscle cells. Physiol. Rev. 62, 672–737 (1982)

    Google Scholar 

  • Lauffenburger, D.: Influence of external concentration fluctuations on leukocyte chemotactic orientation. Cell Biophys. 4, 177–209 (1983)

    Google Scholar 

  • Odell, G., Oster, G., Burnside, B., Alberch, P.: The mechanical basis of morphogenesis I: Epithelial folding and invagination. Devel. Biol. 85, 446–462 (1981)

    Google Scholar 

  • Oster, G., Odell, G.: A mechanochemical model for plasmodial oscillations in Physarum. In: Proc. Workshop on Pattern Formation. W. Jager (ed.). Berlin, Heidelberg, New York: 1984

  • Oster, G., Odell, G., Alberch, P.: Morphogenesis mechanics and evolution. In: Mathematical Problems in the Life Sciences. Vol. 13. Providence: Amer. Math. Soc., 1980

  • Schmid-Schönbein, G., Skalak, R.: A continuum mechanical model of leukocytes during protopod formation. J. Biomech. Engrg. 106, 10–18 (1984)

    Google Scholar 

  • Snyderman, R., Goetz, E.: Molecular and cellular mechanisms of leukocyte chemotaxis. Science 213, 83037 (1981)

    Google Scholar 

  • Trinkaus, J.: Cells into Organs: Forces that Shape the Embryo. (2nd Ed.). Englewood Cliffs, NJ: Prentice Hall, 1984

    Google Scholar 

  • Zigmond, S.: Ability of polymorphonucluear leukocytes to orient in gradients of J. Cell Biol. 75, 606–616 (1977)

    Google Scholar 

  • Zigmond, S.: Chemotaxis by polymorphonuclear leukocytes. J. Cell Biol. 77, 269–287 (1978)

    Google Scholar 

  • Zigmond, S., Sullivan, S., Lauffenburger, D.: Kinetic analysis of chemotactic peptide receptor modulation. J. Cell Biol. 92, 34–43 (1982)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Oster, G.F., Perelson, A.S. Cell spreading and motility: A model lamellipod. J. Math. Biology 21, 383–388 (1985). https://doi.org/10.1007/BF00276234

Download citation

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00276234

Key words

Navigation