Abstract
Craniosynostosis is described as a condition in which the premature closure of one or more cranial sutures is exposed as a skull deformity alone or accompanied by neurological disturbances. According to previous research it seemed possible to create an experimental model for investigating the disease by simply resecting a suture in a newborn rabbit. We resected 16 coronal sutures in 16 newborn rabbits and had the skulls investigated for shape and histology up to 6 months of age. A clear deformity at the cranial vault could be detected. The fused site of th suturectomy later on presented a suture-like structure which was macroscopically distinct from a normal skull suture. The procedure is thus established, first, for investigating procedures for treating craniosynostosis in the growing skull, and, secondly, for studying the pathophysiology of craniosynostosis.
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Antikainen, T., Kallioinen, M., Waris, T. et al. A new method for the creation and measurement of experimental craniosynostosis. Child's Nerv Syst 8, 457–461 (1992). https://doi.org/10.1007/BF00274408
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DOI: https://doi.org/10.1007/BF00274408