Summary
The effect of ovariectomy on the adrenal gland was studied in the Mongolian gerbil. Castration stimulated cells in the zona fasciculata as well as those in the region between the zona fasciculata and zona reticularis. No alterations occurred in the zona reticularis. The width of the intermediate region was enlarged, the cells were hypertrophic and contained an increased number of concentric whorls of rough endoplasmic reticulum. Smooth endoplasmic reticulum was hypertrophie in cells of the zona fasciculata and intermediate region. Many mitochondria in cells of the intermediate region were larger than those in controls. Stimulation of cellular ultrastructure is directly correlated with a significant elevation in plasma cortisol in ovariectomized gerbils.
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Supported by research grant HL 06975 from the National Heart and Lung Institute. The author is grateful to Mrs. Neonile Fylypiw, Mr. Luther Joseph, Mrs. Elisabeth Lawson, Mrs. Geneva Joseph and Mr. Robert Linsmair for skilled technical assistance.
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Nickerson, P.A. Stimulation of the adrenal gland of the mongolian gerbil after ovariectomy. Cell Tissue Res. 165, 135–139 (1975). https://doi.org/10.1007/BF00222806
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DOI: https://doi.org/10.1007/BF00222806