References
Azzawi M, Bradley B, Jeffery PK, Frew AJ, Wardlaw AJ, Knowles GK, Assoufi B, Collins JV, Durham SR, Kay AB (1990) Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 142:1407
Basten A, Beeson PB (1970) Mechanism of eosinophilia. II. Role of the lymphocyte. J Exp Med 131:1288
Bentley AM, Maestrelli P, Saetta M, Fabbri LM, Robinson DS, Bradley BL, Jeffery PK, Durham SR, Kay AB (1992) Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. J Allergy Clin Immunol 89:821
Bentley AM, Menz G, Storz C, Robinson DS, Bradley BL, Jeffery PK, Durham SR, Kay AB (1992) Identification of T-lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 146:500
Bradley BL, Azzawi M, Jacobson M, Assoufi B, Collins JV, Irani A-M, Schwartz LB, Durham SR, Jeffery PK, Kay AB (1991) Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial responsiveness. J Allergy Clin Immunol 88:661
Brod SA, Benjamin D, Hafler DA (1991) Restricted T cell expression of IL-2/IFN-γ mRNA in human inflammatory disease. J Immunol 147:810
Broide DH, Firestein GS (1991) Endobronchial allergen challenge in asthma: demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization. J Clin Invest 88:1048
Campbell HD, Tucker WQJ, Hort Y, Martinson ME, Mayo G, Clutterbuck EJ, Sanderson CJ, Young IG (1987) Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Proc Natl Acad Sci USA 84:6629
Corrigan CJ, Kay AB (1990) CD4+ T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis 141:970
Corrigan CJ, Hartnell A, Kay AB (1988) T lymphocyte activation in acute severe asthma. Lancet I:1129
DelPrete G, Maggi E, Parronchi P, Chretien I, Tiri A, Macchia D, Ricci M, Banchereau J, DeVries J, Romagnani S (1988) IL-4 is an essential factor for the IgE synthesis induced in vitro by T cell clones and their supernatants. J Immunol 140:4193
DelPrete G-F, DeCarli M, Mastromauro C, Macchia D, Biagiotti R, Ricci M, Romagnani S (1991) Purified protein derivative of mycobacterium tuberculosis and excretory-secretory antigens of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 88:346
Dent LA, Strath M, Mellor AL, Sanderson CJ (1990) Eosinophilia in transgenic mice expressing interleukin-5. J Exp Med 172:1425
Djukanovic R, Roche WR, Wilson JW, Beasley CRW, Twentyman OP, Howarth PH, Holgate ST (1990) Mucosal inflammation in asthma. Am Rev Respir Dis 142:434
Durham SR, Sun Ying, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, Kay AB, Hamid QA (1992) Cytokine messenger RNA expression for IL-3, IL-4, IL-5 and granulocyte/macrophage colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol 148:2390
Ehlers S, Smith KA (1991) Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med 173:25
Filley WV, Holley KE, Kephart GM, Gleich GJ (1982) Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet II:11
Fox CH, Kotler D, Tierney A, Wilson CS, Fauci AS (1989) Detection of HIV-1 RNA in the lamina propria of patients with AIDS and gastrointestinal disease. J Infect Dis 159:467
Frew AJ, Kay AB (1988) The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man. J Immunol 141:4158
Gajewski TF, Schell SR, Fitch FW (1990) Evidence implicating utilization of different T cell receptor-associated signalling pathways by Th1 and Th2 clones. J Immunol 144:4110
Gajewski TF, Pinnas M, Wong T, Fitch FW (1991) Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J Immunol 146:1750
Gilbert RM, Hoang KD, Weigle WO (1990) Th1 and Th2 clones differ in their response to a tolerogenic signal. J Immunol 144:2063
Gleich GJ (1990) The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 85:422
Gordon JR, Galli SJ (1991) Release of both preformed and newly synthesized tumor necrosis factor-α (TNF-α)/cachectin by mouse mast cells stimulated via the FcɛR1. A mechanism for the sustained action of mast cell-derived TNF-α during IgE-dependent biological responses. J Exp Med 174:103
Haanen JBAG, deWaal Malefijt R, Res PCM, Kraakman EM, Ottenhoff THM, de Vries RRP, Spits H (1991) Selection of a human helper type 1-like T cell subset by mycobacteria. J Exp Med 174:583
Hamid Q, Azzawi M, Sun Ying, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley BL, Durham SR, Collins JV, Jeffery PK, Quint DJ, Kay AB (1991) Expression of mRNA for interleukin 5 in mucosal bronchial biopsies from asthma. J Clin Invest 87:1541
Hamid Q, Barkans J, Robinson DS, Durham SR, Kay AB (1992) Co-expression of CD25 and CD3 in atopic allergy and asthma. Immunology 75:659
Hodgkin PD, Yamashita LC, Coffman RL, Kehry MR (1990) Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. J Immunol 145:2025
Holgate ST, Hardy C, Robinson C, Agius RA, Howarth PH (1986) The mast cell as a primary effector cell in the pathogenesis of asthma. J Allergy Clin Immunol 77:274
Hunninghake GW, Bedell GN, Zavala DC, Monick M, Brady M (1983) Role of interleukin-2 release by lung T-cells in active pulmonary sarcoidosis. Am Rev Respir Dis 128:634
Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB (1989) Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 140:1745
Kay AB (1991) Asthma and inflammation. J Allergy Clin Immunol 87:893
Kay AB, Sun Ying, Varney V, Gaga M, Durham SR, Moqbel R, Wardlaw AJ, Hamid Q (1991) Messenger RNA expression of the cytokine gene cluster interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects. J Exp Med 173:775
Kirby JG, Hargreave FE, Gleich GJ, O'Byrne PM (1987) Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 136:379
Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T (1985) Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 131:599
Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vadas MA (1988) Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 167:219
Maggi E, Biswas P, DelPrete G, Parronchi P, Macchia D, Simonelli C, Emmi L, DeCarli M, Tiri A, Ricci M, Romagnani S (1991) Accumulation of the Th2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 146:1169
Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni M-P, Rugiu FS, DeCarli M, Ricci M, Romagnani S (1992) Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 148:2142
Mosmann TR, Coffman RL (1987) Two types of mouse helper T cell clones. Implications for immune regulation. Immunol Today 8:223
Mosmann TR, Coffman RL (1989) Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145
Mosmann TR, Cherwinski H, Bond MW, Gieldin MA, Coffman RL (1986) Two types of murine helper T cell clones. J Immunol 136:2348
O'Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O'Connell EJ, Ballard DJ, Sachs MI (1991) Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 324:359
Owen WF JR, Rothenberg ME, Silberstein DS, Gasson J, Stevens RL, Austen KF, Soberman RJ (1987) Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J Exp Med 166:129
Paliard X, deWaal Malefijt R, Yssel H, Blanchard D, Chretien I, Abrams J, deVries J, Spits H (1988) Simultaneous production of IL-2, IL-4 and IFN-γ by activated human CD4+ and CD8+ T cell clones. J. Immunol 141:849
Parronchi P, Macchia D, Piccinni M-P, Biswas C, Simonelli C, Maggi E, Ricci M, Ansari AA, Romagnani S (1991) Allergen and bacterial antigen-specific T cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 88:4538
Piccinni M-P, Macchia D, Parronchi P, Giudizi M-G, Bani D, Alterini R, Grossi A, Ricci M, Maggi E, Romagnani S (1991) Human bone marrow non-B, non-T cells produce IL-4 in response to cross-linkage of Fcɛ and Fcγ receptors. Proc Natl Acad Sci USA 88:8656
Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP, Paul WE (1989) Mast cell lines produce lymphokines in response to cross-linkage of Fcɛ-R1 or to calcium ionophores. Nature 329:64
Quint DJ, Bolton EJ, McNamee LA, Solari R, Hissey PH, Champion BR, MacKenzie AR, Zanders ED (1989) Functional and phenotypic analysis of human T-cell clones which stimulate IgE production in vitro. Immunology 67:68
Robinson BMS, McLemore TL, Crystal RG (1985) Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis. J Clin Invest 75:1488
Robinson DS, Hamid Q, Ying Sun, Tsicopoulos A, Barkans J, Bentley AM, Corrigan CJ, Durham SR, Kay AB (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326:298
Robinson DS, Bentley AM, Hartnell A, Kay AB, Durham SR (1993) Activated memory T helper cells in bronchoalveolar lavage from atopic asthmatics. Relationship to asthma symptoms, lung function and bronchial responsiveness. Thorax (in press)
Robinson DS, Hamid Q, Bentley AM, Ying Sun, Kay AB, Durham SR (1993) CD4+ T cell activation, eosinophil recruitment and interleukin-4 (IL-4), IL-5, and GM-CSF messenger RNA expression in bronchoalveolar lavage after allergen inhalation challenge in atopic asthmatics (abstract). Thorax (in press)
Romagnani S (1991) Human TH1 and TH2: doubt no more. Immunol Today 12:256
Rothenberg ME, Owen WF Jr, Silberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL (1988) Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to interleukin 3. J Clin Invest 81:1986
Schleimer RP (1990) Corticosteroids: their biologic mechanisms and application to the treatment of asthma. Am Rev Respir Dis 141:S59
Seder RA, Paul WE, Dvorak AM, Sharkis SJ, Kagey-Sobotka A, Niv Y, Finkelman FD, Barbieri SA, Galli SJ, Plaut M (1991) Mouse splenic and bone marrow cell populations that express high affinity Fcɛ receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci USA 88:2835
Sedgwick JB, Calhoun WJ, Gleich GJ, Kita H, Abrams JS, Schwartz LB, Volovitz B, Ben-Yaakov M, Busse WW (1991) Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Am Rev Respir Dis 144:1274
Snapper CM, Paul WE (1987) Interferon-γ and B-cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944
Swain SL, Weinberg AD, English M, Huston G (1990) IL-4 directs the development of Th2-like helper effectors. J Immunol 145:3796
Tsicopoulos A, Hamid Q, Varney V, Ying Sun, Moqbel R, Durham SR, Kay AB (1992) Preferential messenger RNA expression of Th1-type cells (IFN-γ+, IL-2+) in classical delayed-typ (tuberculin) hypersensitivity reactions in human skin. J Immunol 148:2058
Varney VA, Jacobson MR, Sudderick RM, Robinson DS, Irani A-MA, Schwartz LB, Mackay IS, Kay AB, Durham SR (1992) Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils and neutrophils. Am Rev Respir Dis 145:170
Vercelli D, Tabara HH, Arai K, Yokata T, Geha RS (1989) Endogenous IL-6 plays an obligatory rote in IL-4-induced human IgE synthesis. Eur J Immunol 19:1419
Walker C, Kaegi MK, Braun P, Blaser K (1991) Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 88:935
Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow J-C Jr (1992) Allergic and non-allergic asthmatics have different patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 146:109
Walsh GM, Hartnell A, Wardlaw AJ, Kurihara K, Sanderson CJ, Kay AB (1990) IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 71:258
Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB (1988) Eosinophils and mast cells in bronchoalveolar lavage in mild asthma: relationship to bronchial hyperreactivity. Am Rev Respir Dis 137:62
Wierenga EA, Snoek M, deGroot C, Chretien I, deBos J, Jansen HM, Kapsenberg ML (1990) Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic subjects. J Immunol 144:4651
Wodnar-Filipowicz A, Heusser CH, Moroni C (1989) Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 339:150
Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL (1991) Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277
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Robinson, D.S., Hamid, Q., Jacobson, M. et al. Evidence for Th2-type T helper cell control of allergic disease in vivo. Springer Semin Immunopathol 15, 17–27 (1993). https://doi.org/10.1007/BF00204623
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DOI: https://doi.org/10.1007/BF00204623