References
Blumberg, R. S., Ley, S., Sancho, J., Lonberg, N., Lacy, E., McDermott, F., Schad, V., Greenstein, J. L., and Terhorst, C.: Structure of the T-cell antigen receptor: evidence for two CD3 ε subunits in the T-cell receptor-CD3 complex. Proc Natl Acad Sci USA 87: 7220–7224, 1990
Colaco, C. A. L. S. and Levins, B.: The rat ζ-chain, a distinct component of the T-cell antigen receptor. Immunogenetics 35: 412–415, 1992
Exley, M., Terhorst, C., and Wileman, T.: Structure, assembly and intracellular transport of the T-cell receptor for antigen. Semin Immunol 3: 283–297, 1991
Frank, S. J., Engel, I., Rutledge, T. M., and Leutourneur, F.: Structure/function analysis of the invariant subunits of the T-cell antigen receptor. Semin Immunol 3: 299–311, 1991
De la Hera, A., Muller, U., Olsson, C., Isaaz, S., and Tunnacliffe, A.: Structure of the T-cell antigen receptor (TCR): two CD3ε subunits in a functional TCR/CD3 complex. J Exp Med 173: 7–17, 1991
Geisler, C., Rubin, B., Caspar-Bauguil, S., Champagne, E., Vangsted, A., Hou, X., and Gajhede, M.: Structural mutations of C-domains in members of the Ig superfamily. Consequences for the interactions between the T-cell antigen receptor and the ζ2 homodimer. J Immunol 148: 3469–3477, 1992
Gold, D. P., Puck, J. M., Pettey, C. L., Cho, M., Coligan, J., Woody, J. N., and Terhorst, C., Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex. Nature 321: 431–434, 1986
Gold, D. P., Clevers, H., Alarcon, B., Dunlap, S., Novotny, J., Williams, A. F., and Terhorst, C.: Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc Natl Acad Sci USA 84: 7649–7653, 1987
Grossberger, D., Marcuz, A., Fichtel, A., Dudler, L., and Hein, W. R.: Sequence analysis of sheep T-cell receptor β chains. Immunogenetics 37: 222–226, 1992
Hein, W. R., Dudler, L., Marcuz, A., and Grossberger, D.: Molecular cloning of sheep T-cell receptor γ and δ chain constant regions: unusual primary structure of γ chain hinge segments. Eur J Immunol 20: 1795–1804, 1990
Hein, W. R. and Tunnacliffe, A.: Characterization of the CD3γ and δ invariant subunits of the sheep T-cell antigen receptor. Eur J Immunol 20: 1505–1511, 1990
Hein, W. R., Marcuz, A., Fichtel, A., Dudler, L., and Grossberger, D.: Primary structure of the sheep T-cell receptor α chain. Immunogenetics 34: 39–41, 1991
Jensen, J. P., Hou, D., Ramsburg, M., Taylor, A., Dean, M., and Weissman, A. M.: Organization of the human T-cell receptor ζ/η gene and its genetic linkage to the FcγRII-FcγRIII gene cluster. J Immunol 148: 2563–2571, 1992
Jin, Y.-J., Clayton, L. K., Howard, F. D., Koyasu, S., Sieh, M., Steinbrich, R., Tarr, G. E., and Reinherz, E. L.: Molecular cloning of the CD3η subunit identifies a CD3ζ-related product in thymus-derived cells. Proc Natl Acad Sci USA 87: 3319–3323, 1990
Kimura, M.: Evolutionary rate at the molecular level. Nature 217: 624–626, 1968
Kimura, M.: The Neutral Theory of Molecular Evolution. Cambridge University Press, Cambridge, UK, 1983
Letourneur, F. and Klausner, R. D.: Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 ε. Science 255: 79–82, 1992
Mallabiabarrena, A., Fresno, M., and Alarcon, B.: An endoplasmic reticulum retention signal in the CD3ε chain of the T-cell receptor. Nature 357: 593–596, 1992
Nash, R. A., Scherf, U., and Storb, R.: Molecular cloning of the CD3ε subunit of the T-cell receptor/CD3 complex in dogs. Immunogenetics 33: 396–398, 1991
Peter, M. E., Hall, C., Ruhlmann, A., Sancho, J., and Terhorst, C.: The T-cell receptor ζ chain contains a GTP/GDP binding site. EMBO J. 11: 933–941, 1992
Reth, M.: Antigen receptor tail clue. Nature 338: 383–384, 1989
Thiesen, H.-J., Casorati, G., Lauster, R., and Wiles, M. V.: Application of polymerase chain reaction in molecular immunology. In I. Lefkovits and B. Pernis (eds.): Immunological Methods Vol. IV, pp. 35–60, Academic Press, 1990
Wegener, A.-M. K., Letourneur, F., Hoeveler, A., Brocker, T., Luton, F., and Malissen, B.: The T-cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell68: 83–95, 1992
Weissman, A. M., Hou, D., Orloff, D. G., Modi, W., Seuanez, H., O'Brien, S. J. and Klausner, R. D.: Molecular cloning and chromosomal localization of the human T-cell receptor ζ chain: Distinction from the molecular CD3 complex. Proc Natl Acad Sci USA 85: 9709–9713, 1988a
Weissman, A. M. Baniyash, M., Hou, D., Samelson, L. E., Burgess, W. H., and Klausner, R. D.: Molecular cloning of the ζ chain of the T-cell antigen receptor. Science 239: 1018–1021, 1988b
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The nucleotide sequences reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession numbers Z12968 and Z12969.
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Hein, W.R., Tunnacliffe, A. Invariant components of the sheep T-cell antigen receptor: cloning of the CD3 ε and Tcr ζ chains. Immunogenetics 37, 279–284 (1993). https://doi.org/10.1007/BF00187454
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DOI: https://doi.org/10.1007/BF00187454