Abstract
Nanoparticles (NPs) currently have extensive applications in nearly all the consumer products like cosmetics, food items, textiles, sports tools, electronic materials, and biomedical applications. Interestingly, advances in nanomedicine are capable of providing solutions for early diagnosis of diseases that is extremely useful in devastating diseases like cancer, neurodegeneration, etc. However, despite these gigantic benefits of nanoparticles, their dosage is of great concern, as its influence on human health is dose dependent. It is a prerequisite to appraise physico-chemical property and dosage of the nanoparticle before its integration in human-related products and biomedical application.
Reproduction and survival are essential for the perpetuation of any species, yet it is extremely fragile as compared to any other system. Nanoparticles are being utilized in countless consumer products, but their dosage or concentration has not been investigated. Research in model organisms displayed that nanoparticles, particularly at higher dosage, have significant effect on reproductive system and survival of the progeny. Drosophila is an excellent model organism to evaluate consequence of nanoparticle dosage on female reproduction and aging as multiple concentrations can be tested at ease due to large number of offsprings.
In the present chapter, we have discussed about one of the most crucial parameters to be considered before incorporation of nanoparticles in consumer products which is to evaluate dosage effect of nanoparticles on female reproduction and survival, the most imperative elements of life.
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Raj, A., Shah, P., Agrawal, N. (2020). Dose-Dependent Influence of Nanoparticles on Fertility and Survival. In: Agrawal, N., Shah, P. (eds) Toxicology of Nanoparticles: Insights from Drosophila. Springer, Singapore. https://doi.org/10.1007/978-981-15-5522-0_4
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