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Worms on a Chip

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Book cover Applications of Microfluidic Systems in Biology and Medicine

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 7))

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Abstract

Advancement in miniaturization in recent years has enabled high-throughput, in-parallel, rapid, and precise operations in modern medical and biological research. Although numerous biomimetic devices have been inspired by nature cues, the artificial gadgets still cannot be on a par with their natural counterparts. Caenorhabditis elegans (C. elegans), the smallest multi-cellular model animal, has become a popular platform for drug screening, biosensing, genetic engineering, neuroscience, developmental biology, and so forth since its first debut made by Sydney Brenner nearly five decades ago. The nematode C. elegans features small size, transparency body, fully sequenced genomes, high genetic similarity with humans, short life cycle, and simple neural network. The combination of C. elegans and microchip can prompt promising uses in some aspects. To cope with the new demands, the scientific community has endeavored great efforts to meet all sorts of worm maneuvers, such as sorting, immobilization, long-term imaging, confined culture, and biomechanics. The proposed manipulation repertoire then leads to realizations of a wide applications. Examples may include drug screening for pharmaceutics, point-of-care testing (POCT) for diseases, and fundamental research. Although worms-on-a-chip (WoC) appears to remain in its infancy stage of development, intensive research has gradually unveiled novel possibilities in many potential fields. This chapter aims to introduce the current development of WoCs and provides examples according to their categories. Pros and cons will be addressed in the end. Some practical uses will also be suggested for the future prospects.

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Acknowledgements

This work was supported by the Ministry of Science and Technology in Taiwan under the grants 107-2221-E-006-054-MY3 and 107-2622-E-006-022-CC2. W.-H.Wang is grateful to the financial support from the One-Thousand Young Talent Program of China.

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Authors and Affiliations

  1. Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan

    Han-Sheng Chuang

  2. Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan

    Han-Sheng Chuang

  3. State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China

    Wen-Hui Wang

  4. Department of Biochemical and Molecular Biology, National Cheng Kung University, Tainan, Taiwan

    Chang-Shi Chen

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  1. Han-Sheng Chuang
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  2. Wen-Hui Wang
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Correspondence to Han-Sheng Chuang .

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  1. Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo, Japan

    Manabu Tokeshi

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Chuang, HS., Wang, WH., Chen, CS. (2019). Worms on a Chip. In: Tokeshi, M. (eds) Applications of Microfluidic Systems in Biology and Medicine . Bioanalysis, vol 7. Springer, Singapore. https://doi.org/10.1007/978-981-13-6229-3_6

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