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Protection of Spiral Ganglion Neurons and Prevention of Auditory Neuropathy

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Hearing Loss: Mechanisms, Prevention and Cure

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1130))

Abstract

In the auditory system, the primary sensory neurons, spiral ganglion neurons (SGNs), transmit complex acoustic information from hair cells to the second-order sensory neurons in the cochlear nucleus for sound processing, thus building the initial bridge between the physical world of sound and the perception of that sound. Cochlear SGN loss causes irreversible hearing impairment because this type of neural cell cannot regenerate. A better understanding of the molecular mechanisms of formation, structure, degeneration, and protection of SGNs will help to design potential therapeutic strategies for preservation and replacement of them in the cochlear implant recipient. In this review, we described and summarized the following about SGNs: (1) their cell biology and their peripheral and central connections, (2) mechanisms of their neuronal damage and their protection, and (3) the neural and synaptic mechanism of auditory neuropathy and current options for hearing rehabilitation from auditory neuropathy. The updates of the research progress and the significant issues on these topics were discussed.

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Authors and Affiliations

  1. Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong Provincial ENT Hospital Affiliated to Shandong University, Jinan, China

    Wenwen Liu, Xue Wang, Man Wang & Haibo Wang

  2. Shandong Provincial Key Laboratory of Otology, Jinan, China

    Wenwen Liu, Xue Wang, Man Wang & Haibo Wang

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  1. Wenwen Liu
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  2. Xue Wang
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  3. Man Wang
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  4. Haibo Wang
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  1. Key Laboratory of Hearing Medicine of NHFPC, ENT Institute and Otorhinolaryngology Department, Shanghai Engineering Research Centre of Cochlear Implant, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China

    Huawei Li

  2. MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China

    Renjie Chai

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Liu, W., Wang, X., Wang, M., Wang, H. (2019). Protection of Spiral Ganglion Neurons and Prevention of Auditory Neuropathy. In: Li, H., Chai, R. (eds) Hearing Loss: Mechanisms, Prevention and Cure. Advances in Experimental Medicine and Biology, vol 1130. Springer, Singapore. https://doi.org/10.1007/978-981-13-6123-4_6

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