Abstract
Theserotonergic system plays a crucial role in cognition and is a target of many psychiatric treatments. In particular, serotonin 5-HT1A receptors (5-HT1AR) in the prefrontal cortex and hippocampus play key roles in learning, memory, behavioral flexibility, and response inhibition. Here, we investigated how 5-HT1A receptors influence neural network dynamics in the prefrontal cortex and hippocampus and prefronto-hippocampal functional connectivity in alert mice. We found that pharmacological stimulation of 5-HT1AR with 8-OH-DPAT markedly reduces theta, beta, and high gamma oscillations in both areas and weakens prefronto-hippocampal phase synchronization at theta and beta frequencies. Pharmacological inhibition of 5-HT1A receptors with WAY-100635 reduces theta and high gamma oscillatory activity but increases beta and delta oscillations. It also weakens prefronto-hippocampal phase synchronization at theta frequencies. These results reveal that prefronto-hippocampal neurodynamics are highly sensitive to 5-HT1A manipulation and may be relevant for understanding the actions of psychiatric medication targeting the serotonergic system.
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References
Pompeiano, M., Palacios, J.M., Mengod, G.: Distribution and cellular localization of mrna coding for 5-ht1a receptor in the rat brain: correlation with receptor binding. J. Neurosci. 12, 440–453 (1992)
Puig, M.V., Gener, T.: Serotonin modulation of prefronto-hippocampal rhythms in health and disease. ACS Chem. Neurosci. 6, 1017–1025 (2015)
Leiser, S.C., Li, Y., Pehrson, A.L., Dale, E., Smagin, G., Sanchez, C.: Serotonergic regulation of prefrontal cortical circuitries involved in cognitive processing: a review of individual 5-HT receptor mechanisms and concerted effects of 5-HT receptors exemplified by the multimodal antidepressant vortioxetine. ACS Chem. Neurosci. 6, 970–986 (2015)
Robbins, T.W., Arnsten, A.F.T.: The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Annu. Rev. Neurosci. 32, 267–287 (2009)
Robbins, T.W.: Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 362, 917–932 (2007)
Meneses, A., Perez-Garcia, G.: 5-HT1A receptors and memory. Neurosci. Biobehav. Rev. 31, 705–727 (2007)
Ögren, S.O., Eriksson, T.M., Elvander-Tottie, E., D’Addario, C., Ekström, J.C., Svenningsson, P., Meister, B., Kehr, J., Stiedl, O.: The role of 5-HT1A receptors in learning and memory. Behav. Brain Res. 195, 54–77 (2008)
Meltzer, H., Massey, B.: The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr. Opin. Pharmacol. 11, 59–67 (2011)
Carr, G.V., Lucki, I.: The role of serotonin receptor subtypes in treating depression: a review of animal studies. Psychopharmacology. 213, 265–287 (2011)
Tauste-Campo, A., Martinez-Garcia, M., Nácher, V., Luna, R., Romo, R., Deco, G.: Task-driven intra- and interarea communications in primate cerebral cortex. Proc. Natl. Acad. Sci. U. S. A. 112, 4761–4766 (2015)
Cohen, J.: A power primer. Psychol. Bull. 112, 155–159 (1992)
Celada, P., Puig, M. V., Artigas, F.: Serotonin modulation of cortical neurons and networks. Front. Neural Circuits. 19, 7–25 (2013)
Acknowledgments
We thank J. Chanovas and P. Nebot for excellent technical assistance. This work was supported by a NARSAD Young Investigator Award and a SAF2016-80726-R (AEI/FEDER, UE) to M.V. Puig.
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Gener, T., Tauste-Campo, A., Alemany-González, M., Delgado-Sallent, C., Puig, M.V. (2018). Serotonin 5-HT1A Receptors Modulate Neural Rhythms in Prefrontal Cortex and Hippocampus and Prefronto-Hippocampal Connectivity in Alert Mice. In: Delgado-García, J., Pan, X., Sánchez-Campusano, R., Wang, R. (eds) Advances in Cognitive Neurodynamics (VI). Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-10-8854-4_20
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DOI: https://doi.org/10.1007/978-981-10-8854-4_20
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