Abstract
We study the evolution of genetic sequences by means of a coupled map lattice model. Mutations generate short range interactions while ecological constraints define a network with long range interactions. Experimental information and trends from the statistical analysis of the sequence composition are incorporated in the modelling allowing for evolution fitness criteria. Concepts such as quasi-species and error threshold emerge in a natural way. The model gives qualitative predictions regarding the stability under mutations of AIDS RNA sequences which are corroborated experimentally. The relation of the model with other formalisms used in the study of biological networks such as neural nets is pointed out.
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Cocho, G., Santiago, A.G., Martínez-Mekler, G. (1993). An Interplay Between Local and Global Dynamics in Biological Networks: The Case of Genetic Sequences. In: Boccara, N., Goles, E., Martinez, S., Picco, P. (eds) Cellular Automata and Cooperative Systems. NATO ASI Series, vol 396. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1691-6_8
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DOI: https://doi.org/10.1007/978-94-011-1691-6_8
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