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Third European Rheology Conference and Golden Jubilee Meeting of the British Society of Rheology pp 453–455Cite as

The Effects of Co-Solvent Levels and Neutralisation on the Rheology of Carbopol Gels

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Abstract

Carbopol (TM, B.F. Goodrich Co.) resins are synthetic, acidic polymers, utilised within the pharmaceutical industry in topical formulations due to their ability to form gels in suitable solvents with the aid of certain neutralising agents. Systems containing different neutralising agents and co-solvents were prepared to assess the changes in consistency with each formulation. The viscosity in these systems was measured using the flow package on a Carri-Med CS Rheometer, a controlled stress instrument. This rheometer was found to give comparable results to those obtained with controlled shear instruments. Carbopol gels have a maximum viscosity over a particular pH range when neutralised with sodium hydroxide, and within this range addition of different co-solvents up to a maximum concentration of 40 to 50% increases the system viscosity.

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References

  1. Carbopol - water-soluble resins. B.F. Goodrich Company.

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  2. Martindale Extra Pharmacopoeia. 29th Edition. Pharmaceutical Press, p.1433.

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  3. Handbook of Pharmaceutical Excipients. Pharmaceutical Press, 1986. p.41.

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  4. Bentley’s Textbook of Pharmaceutics. E.A. Rawlins. Balliére Tindall, 8th Edition, p.98.

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  5. Barry, B.W. and Meyer, M.C., The Rheological properties of Carbopol gels. 1. Continuous shear and creep properties of Carbopol Gels. Int. J. Pharm., 1979, 2, 1–25.

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Authors and Affiliations

  1. Formulation and Analytical Development Department, SmithKline Beecham Pharmaceuticals, Clarendon Road, Worthing, UK

    Jenny Slater

Authors
  1. Jenny Slater
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Editors and Affiliations

  1. School of Chemical Engineering, University of Birmingham, UK

    D. R. Oliver

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© 1990 Elsevier Science Publishers Ltd

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Slater, J. (1990). The Effects of Co-Solvent Levels and Neutralisation on the Rheology of Carbopol Gels. In: Oliver, D.R. (eds) Third European Rheology Conference and Golden Jubilee Meeting of the British Society of Rheology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0781-2_153

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  • DOI: https://doi.org/10.1007/978-94-009-0781-2_153

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6838-3

  • Online ISBN: 978-94-009-0781-2

  • eBook Packages: Springer Book Archive

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