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Colon Cancer and Midkine

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Book cover Midkine: From Embryogenesis to Pathogenesis and Therapy

Abstract

Midkine, a heparin-binding growth factor, promotes the growth, survival, and migration of various cell populations, and it is over-expressed in many malignant human tumors. Midkine expression is generally increased in colon carcinomas compared to normal colon tissue. Additionally, colon adenomas with medium-to severe-dysplasia exhibit increased midkine expression. Therefore, midkine is expressed during the early stages of colon carcinogenesis and is likely to be involved in the oncogenic process, presumably by promoting tumor cell growth and survival. In the advanced tumor stages, midkine is expected to contribute to tumor progression by promoting tumor angiogenesis. A truncated form of midkine mRNA, which lacks the sequence encoding the N-terminal domain, is expressed in colon cancers in a cancer-specific manner. Detection of this sequence might help to detect micro metastases. Furthermore, the truncated midkine mRNA appears to contribute to colon carcinogenesis because a genetic variant favoring its formation is more frequently found in patients with colon carcinoma compared to unaffected controls. Finally, midkine inhibitors are expected to be valuable in colon cancer treatment; antisense oligo-DNA has been proven to suppress cancer growth in experimental systems.

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Acknowledgements

We are grateful to Mr. Sirin Demir (Yüzüncü Yıl University, Department of Foreign Languages) for many helpful suggestions and comments.

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Authors and Affiliations

  1. Department of General Surgery, University of Yüzüncü Yıl, Van, Turkey

    Özgür Kemik

  2. Department of Biochemistry, Faculty of Medicine, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Ahu Sarbay Kemik

  3. Department of Gastroenterology, University of Yüzüncü Yıl, Van, Turkey

    A. Cumhur Dülger

Authors
  1. Özgür Kemik
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  2. Ahu Sarbay Kemik
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  3. A. Cumhur Dülger
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Corresponding author

Correspondence to Özgür Kemik .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Yilanli Ayazma 26, Istanbul, 34000, Istanbul, Turkey

    Mine Ergüven

  2. , Department of Health Science, Aichi Gakuin University, 12 Araike, Iwasakicho, Nisshin, Aichi, Japan

    Takashi Muramatsu

  3. , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Millet, Istanbul, Turkey

    Ayhan Bilir

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Funding: Funding was not required to complete this work.

Conflict of interest: The authors declare no competing financial interests.

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© 2012 Springer Science+Business Media B.V.

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Kemik, Ö., Kemik, A.S., Dülger, A.C. (2012). Colon Cancer and Midkine. In: Ergüven, M., Muramatsu, T., Bilir, A. (eds) Midkine: From Embryogenesis to Pathogenesis and Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4234-5_26

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