Summary
Plasma atrial natriuretic polypeptide (ANP) levels were measured in three left ventricular assist device (LVAD) goats with normal hearts, three LVAD goats with fibrillated hearts, and three total artificial heart (TAH) calves. The plasma concentrations of ANP in the LVAD goats with normal hearts were lower than those of the control values, ranging between 6 and 26 pg/mI. The supporting data from similar LVAD experiments suggest that the low levels of plasma ANP of the LVAD animals were due to the low left atrial pressure during LVAD pumping. The ANP levels of the LVAD animals with a fibrillated heart were high, up to 516 pg/ml, because of the high right atrial pressure of 13–21 mmHg In the TAH calves, the plasma ANP values varied irrespective of the changes in atrial pressure for 2 weeks postoperatively, followed by decreasing to the lower limit of the control value. The plasma ANP levels of one calf did not rise even when the central venous pressure increased suddenly to 18 mmHg due to the failure of the right pump on the 54th postoperative day. In conclusion: (a) the LVAD animals showed a normal response of ANP secretion to the altered atrial pressure; (b) the calves with a TAH did not show a uniform profile of the plasma ANP levels after implantation; (c) the plasma ANP concentration of one TAH calf did not react to the increased right atrial pressure in the chronic phase.
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© 1988 Springer Japan
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Taenaka, Y. et al. (1988). Plasma atrial natriuretic polypeptide levels during various types of artificial circulation. In: Akutsu, T., et al. Artificial Heart 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65964-8_34
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DOI: https://doi.org/10.1007/978-4-431-65964-8_34
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-70544-4
Online ISBN: 978-4-431-65964-8
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