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Temperature-Sensitive Changes in Surface Properties of a Poly(N-Isopropylacrylamide) Hydrogel Layer

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Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Summary

A poly(N-isopropylacrylamide)-coated glass was prepared and its interfacial electrokinetic properties were studied with a special emphasis on the phase transition behavior of the hydrogel. The electro-osmotic flow velocity was measured on the hydrogel surface immersed in an electrolyte solution at pH 7.4 as a function of temperature and ionic strength. The data were analyzed with an electrokinetic theory for “soft” surfaces to determine the charge density (zN) and the softness parameter (1/λ) of the hydrogel layer. The charge density (zN) and the softness parameter (1/λ) obtained have been well explained the volume change of the hydrogel.

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References

  1. H. Ohshima, K. Makino, T. Kato, K. Fujimoto, H. Kawaguchi (1993) Electrophoretic mobility of latex particles covered with temperature-sensitive hydrogel layers. J. Colloid Interface Sci. 159:512–514.

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  4. K. Makino, K. Suzuki, Y. Sakurai, T. Okano, H. Ohshima, Electro-osmosis on a thermosensitive-hydrogel surface. J. Colloid Interface Sci., in press.

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Author information

Authors and Affiliations

  1. Facuity of Pharmaceutical Sciences and Institute of Colloid and Interface Science, Science University of Tokyo, 12 Ichigaya Funagawara-machi, Shinjuku-ku, Tokyo 162, Japan

    Kimiko Makino & Hiroyuki Ohshima

  2. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162, Japan

    Ken Suzuki, Yasuhisa Sakurai & Teruo Okano

Authors
  1. Kimiko Makino
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  2. Ken Suzuki
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  3. Yasuhisa Sakurai
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  4. Teruo Okano
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  5. Hiroyuki Ohshima
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

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© 1996 Springer-Verlag Tokyo

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Makino, K., Suzuki, K., Sakurai, Y., Okano, T., Ohshima, H. (1996). Temperature-Sensitive Changes in Surface Properties of a Poly(N-Isopropylacrylamide) Hydrogel Layer. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_89

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  • DOI: https://doi.org/10.1007/978-4-431-65883-2_89

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

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