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Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer

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Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

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Abstract

Previously, we found that the sulfonated poly(glucosyloxyethyl methacrylate) (poly(GEMA)-sulfate), which bears sulfonated D-(+)-glucose, had anticoagulant activity. In this study, we tried to clarify the mechanism of anticoagulant activity of poly(GEMA)-sulfate. So we carried out activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests to recognize the mechanism of anticoagulant activity for poly(GEMA)-sulfate. The results of these in vitro clotting tests showed that poly(GEMA)-sulfate had anticoagulant activity of which mechanism was different from that of heparin. It seems that inhibiting fibrin network formation of anticoagulant may be occurred by the entrapment of fibrinogen by poly(GEMA)-sulfate or inhibiting thrombin activity by the activation of heparin cofactor II.

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References

  1. Sakamoto N, Suzuki K, Kishida A, Akashi M (1993) Physical activity of sulfonated glucoside polymer. Polym.Prepr.Jpn. 42: E1060

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  2. Fukudome N, Suzuki K, Yahshima E, Akashi M (1994) Synthesis of nonionic and anionic hydrogels bearing a monosaccharide residues and their properties. J.Appl.Polym.Sci., 52, 1759–1763.

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Authors and Affiliations

  1. Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890, Japan

    Nobuyuki Sakamoto, Kazuya Suzuki, Akio Kishida & Mitsuru Akashi

Authors
  1. Nobuyuki Sakamoto
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  2. Kazuya Suzuki
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  3. Akio Kishida
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  4. Mitsuru Akashi
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

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© 1996 Springer-Verlag Tokyo

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Sakamoto, N., Suzuki, K., Kishida, A., Akashi, M. (1996). Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_46

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  • DOI: https://doi.org/10.1007/978-4-431-65883-2_46

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

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