Abstract
Ganglioside GM3 has been known to participate in insulin signaling by regulating the association of insulin receptor in caveolae microdomains (lipid rafts). Studies on the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 in adipocytes lead to a working hypothesis “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides.” It is expected the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy “membrane microdomain ortho-signaling therapy.”
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References
Chavez JA, Siddique MM, Wang ST et al (2014) Ceramides and glucosylceramides are independent antagonists of insulin signaling. J Biol Chem 289:723–734
Inokuchi J (2011) Physiopathological function of hematoside (GM3 ganglioside). Proc Jpn Acad Ser B Phys Biol Sci 87:179–198
Inokuchi J, Radin N (1987) Preparation of the active isomer of 1-phenyl2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. J Lipid Res 28:565–571
Ishii A, Ohta M, Watanabe Y et al (1998) Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. J Biol Chem 273:31652–31655
Kabayama K, Sato T, Kitamura F et al (2005) TNF alpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. Glycobiology 15:21–29
Kabayama K, Sato T, Saito K et al (2007) Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A 104:13678–13683
Regina T, Hakomori SI (2008) Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim Biophys Acta 1780:421–433
Tagami S, Inokuchi J, Kabayama K et al (2002) Ganglioside GM3 participates in the pathological conditions of insulin resistance. J Biol Chem 277:3085–3092
Yamashita T, Hashiramoto A, Haluzik M et al (2003) Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A 100:3445–3449
Zhao H, Przybylska M, Wu IH et al (2007) Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes 56:1210–1218
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Inokuchi, Ji. (2014). GM3 Synthase (ST3Gal5) and Diabetes . In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_210-1
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DOI: https://doi.org/10.1007/978-4-431-54836-2_210-1
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Publisher Name: Springer, Tokyo
Online ISBN: 978-4-431-54836-2
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