TGF-β and Cardiovascular Disorders

van Meeteren, Laurens A.; Goumans, Marie-José; Dijke, Peter ten

doi:10.1007/978-4-431-54409-8_13

TGF-β and Cardiovascular Disorders

Laurens A. van Meeteren³,
Marie-José Goumans³ &
Peter ten Dijke³

Chapter
First Online: 01 January 2013

1234 Accesses
1 Citations

Abstract

Transforming growth factor β (TGF-β) is a secreted pleiotropic cytokine that is involved in a wide range of biological processes and has essential roles in development and tissue homeostasis. TGF-β elicits cellular effects by activating serine/threonine kinase receptors located at the plasma membrane and intracellular Smad effector proteins. TGF-β is an important (cardio)vascular regulator as shown by many in vitro studies on cultured endothelial and mural cells, in vivo studies in animal models, and genetic studies in which mutations in human TGF-β signaling components have been causally linked to cardiovascular diseases. Here we review recent progress in our understanding of the (dys)function of TGF-β in the cardiovascular system.

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Acknowledgments

Research on TGF-β in vascular disorders in our laboratory is supported by grants from Dutch Cancer Society, Netherlands organization for scientific research, KNAW, and the LeDucq foundation.

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Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Postzone S-1-P, 9600, Leiden, 2300, The Netherlands
Laurens A. van Meeteren, Marie-José Goumans & Peter ten Dijke

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Laurens A. van Meeteren
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Marie-José Goumans
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Peter ten Dijke
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Correspondence to Peter ten Dijke .

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, Dept Medical Biochem Microbiol, Uppsala University, Box 582, Uppsala, SE-751 23, Sweden
Aristidis Moustakas
, Interdiscip. Grad. Sch. Med. Eng., University of Yamanashi, 1110 Shimokato, Chuo, 409-3898, Yamanashi, Japan
Keiji Miyazawa

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van Meeteren, L.A., Goumans, MJ., Dijke, P.t. (2013). TGF-β and Cardiovascular Disorders. In: Moustakas, A., Miyazawa, K. (eds) TGF-β in Human Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54409-8_13

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DOI: https://doi.org/10.1007/978-4-431-54409-8_13
Published: 18 May 2013
Publisher Name: Springer, Tokyo
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