Abstract
I first met Dr. Setsuro Ebashi in 1954, when he was an instructor (or assistant professor) in the Department of Pharmacology, the University of Tokyo, and I was an undergraduate student. Our group of students was doing some experiments on dogs in the corner of the department, which Professor Ebashi had kindly allowed us to use. He was quite kindhearted, but when talking with him one immediately recognized his brilliance, and his penetrating eyes aroused a feeling of awe in us. I did not realize it then, but this was the time when he was establishing the fact that the essential principle of Marsh’s relaxing factor is not a soluble enzyme such as creatine kinase or myokinase, but a microsomal ATPase described by Kielley and Myerhof in 1948.1
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2.1. References
H. Kumagai, S. Ebashi, and F. Takeda, Essential relaxing factor in muscle other than myokinase and creatine phosphokinase. Nature 176, 166–168 (1955).
E. Bozler, Relaxation in extracted muscle fibers. J. Gen. Physiol. 38, 149–159 (1954).
F. Ebashi, and S. Ebashi, On the substances that cause relaxation of glycerinated muscle. (in Japanese) Folia Pharmacol. Jap. 55, 31§ (1959).
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S. Ebashi, Third component participating in the superprecipitation of “natural actomyosin.” Nature 200 1010 (1963).
M. Endo, Comment. Proc. Roy. Soc. Lond. B160, 500 (1964).
S. Ebashi, and A. Kodama, A new protein factor promoting aggregation of tropomyosin. J. Biochem. 58, 107–108 (1965).
M. Endo, Y. Nonomura, T. Masaki, I. Ohtsuki, and S. Ebashi, Localization of native tropomyosin in relation to striation patterns. J. Biochem. 60, 605–608 (1966).
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Endo, M. (2007). Professor Ebashi’s Journey Toward the Discovery of Troponin: A Personal Recollection. In: Ebashi, S., Ohtsuki, I. (eds) Regulatory Mechanisms of Striated Muscle Contraction. Advances in Experimental Medicine and Biology, vol 592. Springer, Tokyo. https://doi.org/10.1007/978-4-431-38453-3_2
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DOI: https://doi.org/10.1007/978-4-431-38453-3_2
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