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Organization and Expression of tRNA Genes in Drosophila Melanogaster

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Book cover Modified Nucleosides and Cancer

Abstract

Transfer RNA molecules are an integral component of the cellular protein-synthesizing machinery responsible for matching a codon in an RNA with the appropriate anticodon so that the correct amino acid is inserted into the growing polypeptide chain. In addition, tRNA species have also been implicated in various regulatory processes (for review, see LaRossa and Söll 1978). All tRNAs possess similar general structural features which allow for efficient recognition by the ribosome or by some nucleases involved in tRNA maturation. They also contain specific recognition features for interaction with cognate aminoacyl-tRNA synthetases and tRNA modifying enzymes. Thus tRNA, with its relatively small size but diverse structural and functional characteristics, provides a potentially useful molecule for the study of macromolecular structure-function relationships.

The work performed in the authors’ laboratory has been supported by grants from the National Institutes of Health and the National Science Foundation. Theodor Dingermann is a Postdoctoral Fellow of the Deutsche Forschungsgemeinschaft

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Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA

    S. Sharp, L. Cooley, D. DeFranco, T. Dingermann & D. Söll

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  1. S. Sharp
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  2. L. Cooley
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  3. D. DeFranco
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  4. T. Dingermann
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  5. D. Söll
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Editors and Affiliations

  1. Zentrallaboratorium für Mutagenitätsprüfung, Deutschen Forschungsgemeinschaft, Breisacher Strasse 33, D-7800, Freiburg, Germany

    Gisela Nass

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© 1983 Springer-Verlag Berlin • Heidelberg

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Sharp, S., Cooley, L., DeFranco, D., Dingermann, T., Söll, D. (1983). Organization and Expression of tRNA Genes in Drosophila Melanogaster. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-81947-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81949-0

  • Online ISBN: 978-3-642-81947-6

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