Experimental Hypertension and Therapeutic Progress: Vasodilation and Beyond

1. Front Matter

   Pages I-XII

   PDF

2. Endothelin and Experimental Hypertension

   • Wolfgang Böcker, Detlev Ganten, Martin Paul

   Pages 1-14

3. Coculture of Vascular Smooth Muscle and Endothelial Cells

   • Eberhard L. Betz

   Pages 15-23

4. Functional Modifications in Blood Vessels of Hypertensive Rats

   • Théophile Godfraind, Nicole Morel

   Pages 24-37

5. Protection Against Hypertensive Tissue Damage

   • Stanislav Kazda

   Pages 38-48

6. Influence of Calcium Antagonists on Kidney Function of Hypertensive Rats

   • Jiří Heller

   Pages 49-60

7. Effect of Nitrendipine on Coronary Arteries in Spontaneously Hypertensive Rats: An Electron Microscopic and Morphometric Study

   • Heidrun Arnold-Schmiebusch, Klaus Radlinger, Bodo Christ

   Pages 61-69

8. Sinorphan Improves Cardiac Structure and Function in Aged Stroke-Prone Spontaneously Hypertensive Rats

   • Andreas M. Knorr, Claudia Hirth-Dietrich, Johannes-Peter Stasch, Stanislav Kazda

   Pages 70-79

9. Could Kinins Contribute to the Vasculoprotective Effect of Potassium Supplementation?

   • Gloria Valdés, Carlos P. Vio

   Pages 80-89

10. Clinical Relevance of Atrial Natriuretic Peptide

    • Donald R. J. Singer

    Pages 90-112

11. Introduction to Video

    • Franz-Josef Bohle

    Pages 113-115

At the workshop held in Leverkusen on December 1, 1993, Professor Dr. Stanislav Kazda was honored on the occasion of his retirement for his scientific contributions and his involvement in drug development in our company, Bayer AG. In a recent article by Eugene Garfield (Current ContentslLife Sciences 36:3-15, 1993), what most of us participating in this workshop have supposed for years was confirmed: that Kazda is one of the leading scientific authors in academia worldwide. In the said survey of citations of biomedical research articles, Kazda is number 29 in terms of actual impact, individual ~itations, and total number of published manuscripts (and this only covers the time period from 1981 to 1992). In addition, his work has contributed significantly to the number eight ranking of our company in the so-called Corporation List. With the support of colleagues inside and outside the company, Kazda made a new substance class, the 1, 4-dihydropyridines, discovered by Bossert and Vater, well known to the scientific community on a worldwide basis and established its outstanding usefulness in hypertension. He has contributed numerous publi­ cations on the pharmacology of these calcium antagonists and organized several international conferences on the topic. Although he became famous as a cardiovascular pharmacologist, he started his career as a physician with the subjects obstetrics and gynecology. He studied at the Medical Faculty in Prague and at the Universities of Kasan and Kharkow (1950-1957).

• Calcium antagonists
• Calciumantagonisten
• Hochdruck
• Pharmakologie
• Stroke
• hypertension
• pathophysiology
• physiology

• Cardiovascular and Arteriosclerosis Research, Bayer AG, Wuppertal, Germany

  Bernward Garthoff, Andreas M. Knorr

• International Research Pharma, Bayer AG, Wuppertal, Germany

  Wolf-Dieter Busse

• Coordination International Research, Bayer AG, Wuppertal, Germany

  Friedel Seuter

Policies and ethics