Abstract
The cytokines interleukin-1 (IL-1α and IL-1β) and tumor necrosis factor alpha (TNFα) produced by activated mononuclear leukocytes are important mediators of the host response to infection and injury [1]. As IL-1β and TNFα act synergistically in the induction of a shock-like state after intravenous injection into laboratory animals [2], these cytokines are likely to be involved in the pathogenesis of septic shock. During experimental fever induced by intravenous injection of endotoxin into humans, serum levels of TNFα [3] and IL-1β [4] are elevated. Recent publications reported elevated circulating concentrations of IL-1β and TNFα in children with severe infectious purpura [5] and in patients with meningococcal infection [6] or septic shock [4]. The latter studies also describe a correlation between plasma TNFα concentrations and severity of disease. As the highest levels of TNFα were found in patients who died these studies suggest that the reduction in circulating cytokines could be beneficial to critically ill patients.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Dinarello CA (1989) Adv Immunol 44:153–205
Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA (1988) J Clin Invest 81:1162–1172
Michie HR, Manogue KR, Spriggs DR, Revhaug A, O’Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW (1988) N Engl J Med 318:1481–1486
Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JWM, Endres S, Lonnemann G, Corsetti J, Chernow B, Wilmore DW, Wolff SM, Burke JF, Dinarello CA (1990) J Infect Dis 161:79–84
Girardin E, Grau GE, Dayer JM, Roux-Lombard P, the J5 Study Group, Lambert PH (1988) N Engl J Med 319:397–400
Waage A, Halstensen A, Espevik T (1987) Lancet 1:355–357
Lonnemann G, Koch KM, Shaldon S, Dinarello CA (1988) J Lab Clin Med 112:76–86
Endres S, Ghorbani R, Lonnemann G, van der Meer JWM, Dinarello CA (1988) Clin Immunol Immunopathol 49:424–438
Van der Meer JWM, Endres S, Lonnemann G, Cannon JG, Ikejima T, Okusawa S, Gelfand JA, Dinarello CA (1988) J Leukocyte Biol 43:216–223
Cannon JG, van der Meer JWM, Kwiatkowski D, Endres S, Lonnemann G, Burke JF, Dinarello CA (1988) Lymphokine Res 7:457–467
Cheung AK, Chenoweth DE, Otsuka D, Henderson LW (1986) Kidney Int 30:74–80
Floege J, Wilks M, Shaldon S, Koch KM, Smeby LC (1988) Nephrol Dial Transplant 3:784–789
Cohen FE, Dinarello CA (1987) J Leukocyte Biol 42:548
Jones EY, Stuart DI, Walker NPC (1989) Nature 338:225–228
Smith RA, Baglioni C (1987) J Biol Chem 262:6951–6957
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag, Berlin Heidelberg
About this chapter
Cite this chapter
Lonnemann, G., Schindler, R., Dinarello, C.A., Koch, K.M. (1993). Removal of Circulating Cytokines by Hemodialysis Membranes In Vitro. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_78
Download citation
DOI: https://doi.org/10.1007/978-3-642-77405-8_78
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77407-2
Online ISBN: 978-3-642-77405-8
eBook Packages: Springer Book Archive