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Cancer Therapy pp 96–102Cite as

Enhancement of Autologous Bone Marrow Transplantation with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhGM-CSF)

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Abstract

Intensive combination chemotherapy makes long-term survival possible after several lymphoid malignancies. However, a substantial number of patients have poor prognostic factors for remaining in remission and should therefore be treated with additional aggressive chemotherapy during remission. Many studies have shown that high-dose chemotherapy alone or in combination with total-body irradiation followed by bone marrow transplantation (BMT) improves the chances of survival for poor-risk patients with acute lymphoblastic leukemia (ALL) [3, 8]. The prognosis for patients with relapsed intermediate or high-grade non-Hodgkin’s lymphoma (NHL) can be improved by high-dose radiochemotherapy followed by BMT [2, 16]. Patients with Hodgkin’s disease (HD) who do not enter a complete remission with conventional chemotherapy have an unfavorable prognosis [1, 6], as do relapse patients who require treatment with chemotherapy. These patients’ chances of being cured are greater with high-dose chemoradiotherapy followed by bone marrow transplantation than with the usual salvage treatment. Neuroblastoma stage III/IV can only be cured by high-dose chemotherapy followed by BMT during remission as consolidation [15]. However, infectious complications due to bone marrow insufficiency during the immediate post-transplant phase after BMT contribute significantly to morbidity and mortality [12,17]. These infections tend to be more severe than during the granulocytopenia following conventional cytotoxic therapy. The association of the degree and duration of granulocytopenia and an increased risk of infection has long been recognized [10]. In autologous BMT for ALL, the median time for recovery to 500 neutrophils per microliter is 22 days, with a range of 14–40 days [7, 11]. The risk of severe infections and of high morbidity could be reduced markedly if the duration of neutropenia could be shortened significantly.

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References

  1. Appelbaum FR, Sullivan KM, Thomas ED (1985) Marrow transplantation as a treatment for patients with recurrent malignant lymphoma. Int J Cell Cloning 4: 216–217

    Google Scholar 

  2. Appelbaum FR, Thomas ED (1983) Review of the use of marrow transplantation in the treatment of non-Hodgkins lymphomas. J Clin Oncol 7: 440–447

    Google Scholar 

  3. Barrett AJ, Kendra JR, Lucas CF, Joss DV, Joshi R, Desai M, Hugh-Jones K, Phillips RH, Rogers TR, Tabara Z, Williamson S, Hobbs Jr (1982) Bone marrow transplantation for acute lymphoblastic leukemia. Br J Haematol 52: 181–188

    Article  PubMed  CAS  Google Scholar 

  4. Brandt SJ, Kurtzberg J, Atwater SK, Borowitz MJ, Jones RB, Shpall EJ, Gilbert CJ, Bast RC Jr., Oette DH, Peters WP (1987) Effect of recombinant human granulocyte-macrophage colo¬ny-stimulating factor (rHuGM-CSF) on hematopoietic reconstitution following high-dose chemotherapy and autologous bone marrow transplantation (ABMT). Blood 70 [Suppl 1]: 131

    Google Scholar 

  5. Cantrell MA, Anderson D, Cerretti DP, Price V, McKereghan K, Tushinski RJ, Mochizuki DY, Larsen A, Grabstein K, Gillis S, Cosman D (1985) Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. Proc Nat Acad Sci USA 82: 6250–6254

    Article  PubMed  CAS  Google Scholar 

  6. Carella AM, Congiu A, Santini G, Martinengo M, Frassoni F, Nati S, Giordano D, Sessarego C, Raffo MR, Lamparelli T, Marmont AM (1986) High-dose chemotherapy (HDC) and autologous BMT in advanced highly treated Hodkin’s disease (AHT-HD). Bone Marrow Trans-plantation [Suppl] 1: 293–296

    Google Scholar 

  7. Dicke KA, Spitzer G (1986) Clinical studies of autografting in acute lymphocytic leukaemia. Clin Haematol 15 (1): 85–103

    PubMed  CAS  Google Scholar 

  8. Dinsmore RE, Kirkpatrick D, Flomenberg N, Gulati S, Kapoor N, Shauk B, Reid A, Groshen S, O’Reilly RJ (1983) Allogeneic bone marrow transplantation for patients with lymphoblastic leukemia. Blood 62: 381–388

    PubMed  CAS  Google Scholar 

  9. Gasson JC, Weisbart RH, Kaufman SE, Clark SC, Hewick RM, Wong GG, Golde DW (1984) Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils. Science 226: 1339–1342

    Article  PubMed  CAS  Google Scholar 

  10. Gerson SL, Talbot GH, Hurwitz S (1984) Prolonged granulocytopenia: The major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med 100: 345–351

    PubMed  CAS  Google Scholar 

  11. Gorin NC (1987) Autologous bone marrow transplantation: a review of recent advances in acute leukemia. In: Gale RP, Champlin RE (eds) Progress in bone marrow transplantation. Liss, New York, pp 723–750

    Google Scholar 

  12. Link H, Ostendorf P, Wernet P, Reinhart U, Walter E, Fischbach H, Niethammer D, Waller HD (1984) Pulmonary complications after allogeneic bone marrow transplantation. The Tuebingen experience. Exp Hematol 12 [Suppl 15]: 21–22

    Google Scholar 

  13. Metealf D (1984) The haematopoietic colony stimulating factors. Elsevier, Amsterdam

    Google Scholar 

  14. Metealf D (1986) The molecular biology and functions of the granulocyte macrophage colony- stimulating factors. Blood 67: 257

    Google Scholar 

  15. Philip T, Bernard JL, Bordigoni P, Paris A, Philip I, Pinkerton R, Favrot MC, Zucker JM (1986) Vincristine, melphalan, fractionated TBI, with purged ABMT as consolidation for an unselected group of patients with stage IV neuroblastoma. Bone Marrow Transplantation 1 [Suppl 1]: 319

    Google Scholar 

  16. Phillips GL, Herzig RG, Lazarus HM, Fay JW, Griffith R, Herzig GP (1986) High-dose chemotherapy, fractionated total body irradiation, and allogeneic marrow transplantation for malignant lymphoma. J Clin Oncol 4: 480–488

    PubMed  CAS  Google Scholar 

  17. Van der Meer JWM, Guiot HFL, Van den Broek PJ, Van Furth R (1984) Infections in bone marrow transplant recipients. Semin Hematol 21: 123–140

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Bone Marrow Transplant Ward, University Hospital Hannover, Konstantin-Gutschow-Straße 8, 3000, Hannover 61, Germany

    H. Link, M. Freund, H. Kirchner, M. Stoll, H. Schmid, P. Bucsky, J. Seidel, R. E. Schmidt, H. Riehm, H. Poliwoda & K. Welte

  2. Clinical Research, Behringwerke AG Marburg, 3550, Marburg 1, Germany

    G. Schulz

Authors
  1. H. Link
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  2. M. Freund
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  3. H. Kirchner
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  4. M. Stoll
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  5. H. Schmid
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  6. P. Bucsky
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  7. J. Seidel
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  8. G. Schulz
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  9. R. E. Schmidt
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  10. H. Riehm
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  11. H. Poliwoda
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  12. K. Welte
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Editor information

Editors and Affiliations

  1. Department of General Surgery, University of Ulm, Steinhövelstraße 9, 7900, Ulm, Germany

    Hans G. Beger FACS (Professor of Surgery) & Markus Büchler (Lecturer in Surgery) (Professor of Surgery) &  (Lecturer in Surgery)

  2. Division of Tumor Cell Biology, Scripps Clinic & Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Ralph A. Reisfeld

  3. Clinical Research, Behringwerke AG Marburg, P.O. Box 1140, 3550, Marburg, Germany

    Gregor Schulz

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© 1989 Springer-Verlag Berlin · Heidelberg

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Link, H. et al. (1989). Enhancement of Autologous Bone Marrow Transplantation with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhGM-CSF). In: Beger, H.G., Büchler, M., Reisfeld, R.A., Schulz, G. (eds) Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73721-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-73721-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73723-7

  • Online ISBN: 978-3-642-73721-3

  • eBook Packages: Springer Book Archive

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