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Synaptic Plasticity in the Hippocampus pp 109Cite as

Intracellular Injection of Protein Kinase C Causes Changes Similar to Long-Term Potentiation

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Abstract

Protein kinases are involved in many neuronal changes induced by activity. Application of phorbol ester causes changes in transmission across certain hippocampal synapses similar to those seen during LTP (Malenka et al., 1986). For this reason, we have injected purified protein kinase C (PK-C) in CA1 hippocampal cells and tested its effect on synaptic activation by afferents in stratum radiatum. The activity of the kinase was tested biochemically before and after the injection.

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Author information

Authors and Affiliations

  1. Department of Pharmacology III, Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, China

    G.-Y. Hu

  2. Institute of Neurophysiology, University of Oslo, Oslo, Norway

    Ø. Hyalby & P. Andersen

  3. Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, NewYork, NY, USA

    S. I. Walaas, K. Albert & P. Greengard

Authors
  1. G.-Y. Hu
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  2. Ø. Hyalby
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  3. S. I. Walaas
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  4. K. Albert
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  5. P. Greengard
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  6. P. Andersen
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Editor information

Editors and Affiliations

  1. II. Physiologisches Institut, Johannes Gutenberg-Universität, Saarstrasse 21, 6500, Mainz, Germany

    Helmut L. Haas M.D.

  2. Department of Neurosciences MO24, University of California at San Diego, 92093, La Jolla, CA, USA

    György Buzsàki M.D.

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© 1988 Springer-Verlag Berlin Heidelberg

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Cite this paper

Hu, GY., Hyalby, Ø., Walaas, S.I., Albert, K., Greengard, P., Andersen, P. (1988). Intracellular Injection of Protein Kinase C Causes Changes Similar to Long-Term Potentiation. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_31

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  • DOI: https://doi.org/10.1007/978-3-642-73202-7_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73204-1

  • Online ISBN: 978-3-642-73202-7

  • eBook Packages: Springer Book Archive

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