Abstract
Studies during the last decade have established that the MNSs blood group locus corresponds to two, presumably adjacent, genes whiff encode the amino-acid sequences of two (MN and Ss) sialoglycoproteins (SGPs) or glycophorins (A and B) in human red cell (RBC) membranes (reviews: 1–4). The structural difference between the M and N antigens is determined by amino-acid polymorphisms at the 1st (Ser/Leu) and 5th (Gly/Glu) positions of the MN SGP, the complete sequence of which was elucidated (5–8). The sequence of the N-terminal 26 residues (res.) of the Ss SGP is identical with that of the N-specific MN SGP (8,9). This explains the occurrence of an additional N antigen, denoted as ‘N’, on the Ss SGP. A Met/Thr polymorphism at the 29th position of the Ss SGP represents the structural difference between the S and s antigens (8). Recently (10), the sequence of the intramembraneous domain (res. 36–72) of the Ss SGP was determined and found to be rather similar to the corresponding region (res. 65–101) of the MN SGP (Fig. 1).
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References
Issitt, P.D. (1981) The MN blood group system., Montgomery Sci. Publ., Cincinnati.
Anstee, D.J., (1981) Semin. Haematol. 18, 85 95.
Dahr, W. (1983) in: Red cell Membrane Glycoconjugates and Related Genetic Markers (eds. Cartron J.P., Rouger, Ph. & Salmon, Ch.) Librairie Arnette, Paris, pp. 27–36.
Moulds, J. (1983) in: Red Cell Membrane Glycoconjugates and Related Genetic Markers (eds. Cartron, J.P.,Rouger, Ph. & Salmon, Ch.) Librairie Arnette, Paris, pp. 17–26.
Tomita, M., Furthmayr, H. & Marchesi, V.T. (1978) Biochemistry 17, 4756–4770.
Lisowska, E. & Wasniowska, K. (1978) Eur. J. Biochem. 88, 247–252.
Dahr, W. & Uhlenbruck, G. (1978) Hoppe-Seyler’s Z. Physiol. Chem. 359, 835–843.
Dahr, W., Beyreuther, K., Steinbach, H., Gielen, W. & Krüger, J. (1980) Hoppe-Seyler’s Z. Physiol. Chem. 361, 895–906.
Furthmayr, H. (1978) Nature 271, 519–523.
Furthmayr, H. (1978) Nature 271, 519–523.
Unger, P., Orlina, A., Dahr, W., Kordowicz, M., Moulds, J. & Newman, R.A. (1981) in: Proc, 9th Int. Congr. Society for Forensic Haematogenetics, Schmitt & Meyer, Würzburg, pp. 189–193.
Contreras, M., Green, C., Humphreys, J., Tippett, P., Daniels, G., Teesdale, P., Armitage, S. & Lubenko, A. (1984) Vox Sang. 46, 377–386.
Tanner, M.J.A., Anstee, D.J. & Mawby, W.J. (1980) Biochem,. J. 187, 493.500
Laird-Fryer, B., Moulds, J. & Wagoner, L. (1984) in Proc., of the 26th Annual Meeting of the South Central Association of Blood Banks, Vol. 25, No. 3, p. 16.
Blanchard, D., Asseraf, A., Prigent, M.J., Moulds, J., Cnandanayingyong, D. & Cartron, J.P. (1984) Hoppe-Seyler’s Z. Physiol. Chem. 365, 469–478.
Moulds, J. et al. (1985) in preparation.
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Dahr, W., Moulds, J., Unger, P., Blanchard, D., Cartron, J.P. (1986). Serological and Biochemical Investigations on the N.E. Variety of the Dantu Red Cell Phenotype. In: Brinkmann, B., Henningsen, K. (eds) 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.). Advances in Forensic Haemogenetics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71150-3_1
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DOI: https://doi.org/10.1007/978-3-642-71150-3_1
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