PRCII, a Representative of a New Class of Avian Sarcoma Viruses

Vogt, P. K.; Neil, J. C.; Moscovici, C.; Breitman, M. L.

doi:10.1007/978-3-642-67984-1_77

P. K. Vogt,
J. C. Neil,
C. Moscovici &
…
M. L. Breitman

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 26))

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1 Citations

Abstract

The Poultry Research Center Virus II (PRC II) is a replication-defective avian sarcoma virus with envelope determinants of the A and B subgroups. In nonproducing cells transformed by PRCII the products of the replicative genes gag, pol, and env are not demonstrable, but a single polyprotein of Mr 105,000 (p105) can be detected. P105 contains peptides of the gag proteins p19 and p27 plus transformationspecific sequences. It does not contain peptides of gPr95^env of Pr180^gag-PoI (with the possible exception of one pol peptide). The transformation-specific sequences of p105 are distinct form those of p100 of avian carcinoma virus MH2, of p1 10 coded for by avian myelocytoma virus MC29, and of p75 or p40 of avian erythroblastosis virus AEV. They also show no resemblance to p60^src of Rous sarcoma virus. P105 is phosphorylated on a tyrosine residue and has an associated Phosphokinase activity. P105 appears to be capable of autophosphorylation and of phosphorylating homologous immunoglobulin.

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P. K. Vogt
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J. C. Neil
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C. Moscovici
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M. L. Breitman
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Editors and Affiliations

Molekularbiologisch-hämatologische Arbeitsgruppe, Universitäts-Kinderklinik, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany
Rolf Neth
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, 20014, USA
Robert C. Gallo
Institut für Virusforschung, Im Neuenheimer Feld 280, D-6900, Heidelberg 1, Federal Republic of Germany
Thomas Graf
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany
Klaus Mannweiler
Abteilung für Haematologie und Onkologie, Universitäts-Kinderklinik, Martinistr. 52, D-2000, Hamburg 20, Federal Republic of Germany
Kurt Winkler

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Vogt, P.K., Neil, J.C., Moscovici, C., Breitman, M.L. (1981). PRCII, a Representative of a New Class of Avian Sarcoma Viruses. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_77

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DOI: https://doi.org/10.1007/978-3-642-67984-1_77
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10622-7
Online ISBN: 978-3-642-67984-1
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