Abstract
Neurotrophins are proteins that are structurally related and exert profound effects on cells of the nervous system. Four distinct neurotrophin genes have been identified in mice and in humans that encode for small dimeric, secretory proteins named nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4/5 (NT4/5).
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Barde, YA. (1999). Biological Roles of Neurotrophins. In: Hefti, F. (eds) Neurotrophic Factors. Handbook of Experimental Pharmacology, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59920-0_1
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