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Bioreaction Engineering

Modeling and Control

  • Book
  • © 2000

Overview

Editors:
  1. Karl Schügerl

    1. Institute of Technical Chemistry, University of Hannover, Hannover, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Karl-Heinz Bellgardt

    1. Institute of Technical Chemistry, University of Hannover, Hannover, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • The book offers information for libraries and institutes on the actual state of the art in the bioprocess modeling and control

  • For biotechnology companies on data and methods for process improvement and for scale up of bioreactors by R&D personal

  • For persons active in biotechnology labs an improvement of the investigation methods

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XL
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  2. Introduction

    1. Introduction

      • Karl-Heinz Bellgardt
      Pages 1-18

  3. General Principles and Techniques

    1. Front Matter

      Pages 19-19
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    2. Bioreactor Models

      • Karl Schügerl, Karl-Heinz Bellgardt
      Pages 21-43

    3. Bioprocess Models

      • Karl-Heinz Bellgardt
      Pages 44-105

    4. Metabolic Flux Analysis

      • Maria I. Klapa, Gregory Stephanopoulos
      Pages 106-124

    5. Accuracy and Reliability of Measured Data

      • Bernd Hitzmann
      Pages 125-144

    6. Bioprocess Control

      • D. Dochain, M. Perrier
      Pages 145-166

    7. On-Line Simulation Techniques for Bioreactor Control Development

      • Reiner Luttmann, Klaus-Uwe Gollmer
      Pages 167-203

  4. Application of General Principles for Reactor Models

    1. Front Matter

      Pages 205-205
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    2. Application of Computational Fluiddynamics (CFD) to Modeling Stirred Tank Bioreactors

      • Matthias Reuss, Sven Schmalzriedt, Marc Jenne
      Pages 207-246

    3. Bubble Column Bioreactors

      • Andreas Lübbert
      Pages 247-273

  5. Application of General Principles for Process Models Including Control

    1. Front Matter

      Pages 275-275
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    2. Baker’s Yeast Production

      • Karl Heinz Bellgart
      Pages 277-320

    3. Modeling of the Beer Fermentation Process

      • Andreas Lübbert
      Pages 321-348

    4. Lactic Acid Production

      • John Villadsen
      Pages 349-373

    5. Control Strategies for High-Cell Density Cultivation of Escherichia coli

      • Clemens Posten, Ursula Rinas
      Pages 374-390

    6. β-Lactam Antibiotics Production with Penicillium chrysogenum and Acremonium chrysogenum

      • Karl-Heinz Bellgardt
      Pages 391-432

  6. Metabolite Flux Analysis, Metabolic Design

    1. Front Matter

      Pages 433-433
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    2. Quantitative Analysis of Metabolic and Signaling Pathways in Saccharomyces cerevisiae

      • Klaus Mauch, Sam Vaseghi, Matthias Reuss
      Pages 435-477
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Keywords

About this book

The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad­ vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex­ tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.

Editors and Affiliations

  • Institute of Technical Chemistry, University of Hannover, Hannover, Germany

    Karl Schügerl, Karl-Heinz Bellgardt

Bibliographic Information

  • Book Title: Bioreaction Engineering

  • Book Subtitle: Modeling and Control

  • Editors: Karl Schügerl, Karl-Heinz Bellgardt

  • DOI: https://doi.org/10.1007/978-3-642-59735-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Softcover ISBN: 978-3-642-64103-9Published: 21 December 2011

  • eBook ISBN: 978-3-642-59735-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XL, 604

  • Topics: Industrial Chemistry/Chemical Engineering, Biotechnology, Microbiology

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