Abstract
The homeobox is a conserved DNA sequence of about 183 nucleotides identified within a number of Drosophila genes which regulate certain aspects of early development. The homeobox sequence encodes a 61 amino acid homeodomain containing a helix-turn-helix motif which is probably involved in DNA binding. Drosophila genes containing a homeobox include some segmentation genes which are involved in generating a metameric pattern, and many homeotic genes (Gehring 1987). Homeotic genes have roles in establishing segment identity, which involves the specification of positional values along the anteroposterior body axis — a process which must occur in the embryos of all bilateral animals, not only those with a segmented body plan. It is therefore significant that several Drosophila homeobox-containing genes are expressed in patterns which suggest roles in positional specification independent of the process of segmentation (Doyle 1986; Hoey et al., 1986; Akam 1987; Gehring 1987).
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© 1988 Springer-Verlag Berlin · Heidelberg
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Graham, A., Holland, P.W.H., Lumsden, A., Krumlauf, R., Hogan, B.L.M. (1988). Expression of the Homeobox Genes Hox 2.1 and 2.6 During Mouse Development. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_14
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DOI: https://doi.org/10.1007/978-3-642-50059-6_14
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