Abstract
The confrontation of scientists in basic research with the problem of cancer has yielded a multitude of new findings and new approaches in theory and experimental research in recent years. While the selection of promising research approaches in the past tended to be somewhat fortuitous and accidental, i.e., was based on isolated observations of differences between normal and malignant cells, in recent years it has also become possible to investigate the origin, diagnosis as well as possible prevention and therapy of cancer diseases with well-defined aims, following basic principles of cell and molecular biology.
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Kuhn, A., Grummt, I.: Dual role of the nucleolar transcription factor UBF: Transactivator and antirepressor. Proc. Natl. Acad. Sci. USA 89, 7340–7344 (1992)
Schnapp, A., Grummt, I.: Transcription complex formation at the mouse rDNA promoter involves the stepwise association of four transcription factors and RNA polymerase I. J. Biol. Chem. 266, 24588–24595 (1992)
Eberhard, D., Tora, L., Egly, J.M., Grummt, I.: A TBP-containing multisubunit complex (TIF-1B) confers promoter specificity to murine RNA polymerase I. Nucl. Acids Res. 21, 4180–4186 (1993)
Schnapp, A., Schnapp, G., Erny, B., Grummt, I.: Function of the growth-regulated factor TIF-IA in initiation complex formation at the murine rDNA promoter. Mol. Cell. Biol. 13, 6723–6732 (1993)
Schnapp, G., Santori, F., Caries, C., Riva, M., Grummt, I.: The HMG-box containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I. EM-BO J. 13, 190–199 (1994)
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© 1995 Springer-Verlag Berlin Heidelberg
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Schäfer, S., Franke, W.W., Strand, D., Törōk, I., Mechler, B.M., Grummt, I. (1995). Cell Differentiation and Carcinogenesis. In: Current Cancer Research 1995. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-48687-6_4
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DOI: https://doi.org/10.1007/978-3-642-48687-6_4
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-7985-0989-4
Online ISBN: 978-3-642-48687-6
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