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Encyclopedia of Pain pp 1878–1888Cite as

Migraine, Pathophysiology

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Introduction

An understanding of the pathophysiology of migraine should be based upon the anatomy and physiology of the pain-producing structures of the cranium integrated with knowledge of central nervous system modulation of these pathways. Headache in general, and in particular migraine (Goadsby et al. 2002) and cluster headache (Goadsby 2002b), is better understood now than has been the case for the last four millennia (Lance and Goadsby 2005). This entry will set out the current understanding of migraine.

Characteristics

Migraine: Explaining the Clinical Features

Migraine is in essence a familial episodic disorder whose key marker is headache with certain associated features (Table 1). It is these features that give clues to its migraine pathophysiology and will ultimately provide insights leading to new treatments.

Migraine, Pathophysiology, Table 1 International Headache Society defined features of migraine (Headache Classification Committee of The International Headache Society

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Acknowledgment

The work of the author has been supported by the Wellcome Trust.

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  1. Headache Center, Department of Neurology, University of California, San Francisco, CA, 94115, USA

    Peter Goadsby

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  1. Peter Goadsby
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Correspondence to Peter Goadsby .

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  1. Department of Anesthesiology, Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA

    Gerald F. Gebhart

  2. Physiologisches Institut der, Universität Würzburg, Würzburg, Germany

    Robert F. Schmidt

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Goadsby, P. (2013). Migraine, Pathophysiology. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_2425

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