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The Central Insulin System and Energy Balance

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Appetite Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 209))

Abstract

Insulin acts throughout the body to reduce circulating energy and to increase energy storage. Within the brain, insulin produces a net catabolic effect by reducing food intake and increasing energy expenditure; this is evidenced by the hypophagia and increased brown adipose tissue sympathetic nerve activity induced by central insulin infusion. Reducing the activity of the brain insulin system via administration of insulin antibodies, receptor antisense treatment, or receptor knockdown results in hyperphagia and increased adiposity. However, despite decades of research into the role of central insulin in food intake, many questions remain to be answered, including the underlying mechanism of action.

Supported by NIH DK17844; DPB supported by NHMRC Early Career Fellowship GNT1013264.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH, 45237, USA

    Denovan P. Begg & Stephen C. Woods

  2. Department of Medicine, University of Melbourne, Melbourne, VIC, 3010, Australia

    Denovan P. Begg

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  1. Denovan P. Begg
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  2. Stephen C. Woods
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Correspondence to Stephen C. Woods .

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  1. , Department of Pharmacology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany

    Hans-Georg Joost

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Begg, D.P., Woods, S.C. (2012). The Central Insulin System and Energy Balance. In: Joost, HG. (eds) Appetite Control. Handbook of Experimental Pharmacology, vol 209. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24716-3_5

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