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Vitamin Deficiencies and Excess

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Textbook of Clinical Pediatrics

Vitamins are natural chemical compounds required in minute quantities for health and normal nutrition in humans. They are divided into two groups, namely, water and fat-soluble vitamins. The former are pro-coenzymes that provide active substances necessary for enzyme synthesis and the latter alter conformation of complex molecules and membranes.

Water-Soluble Vitamins

Vitamin B Group Deficiencies

As the sources of vitamin B are present in more or less the same type of animal and vegetable foods, X and X deficiency of one is likely to be associated with deficiencies of others. Clinical manifestations of B vitamin deficiencies are usually seen in famine situations in developing countries, where there is also the added potential risk of improper preparation of food with long-term storage due to shortage of water and cooking facilities. Unlike fat-soluble vitamins, excess of water-soluble vitamins is not of significant concern.

Thiamine (B1)

Thiamine forms the heat labile portion of the B...

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References

  • Barclay AJG, Foster A, Sommer A (1987) Vitamin A supplementation and mortality related to measles: a randomized clinical trial. BMJ 294:294–296

    Article  PubMed  CAS  Google Scholar 

  • Bauernfeind JC (1980) The safe use of Vitamin A. International Vitamin A Consultative Group. The Nutrition Foundation, Washington DC

    Google Scholar 

  • Bloem MW, Wedel M, Egger RJ et al (1989) Iron malabsorption and vitamin A deficiency in children in North East Thailand. Am J Clin Nutr 50:332–338

    PubMed  CAS  Google Scholar 

  • Brigelius-Flohe R et al (2002) The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr 76(4):703–716

    PubMed  CAS  Google Scholar 

  • Bye AME, Muler DPR, Wilson J et al (1985) Symptomatic Vitamin E deficiency in cystic fibrosis. Arch Dis Child 60:162–164

    Article  PubMed  CAS  Google Scholar 

  • El Bushra HE, Ash LR, Coulson AH, Neumann CG (1992) Interrelationship between diarrhoea and Vitamin A deficiency; is vitamin A deficiency a risk factor for diarrhoea. Pediatr Inf Dis J 11:380–384

    Article  Google Scholar 

  • Fuchs GJ, Ausayashum S, Suskind RM et al (1994) Relationship between Vitamin A deficiency, malnutrition and conjunctiva impression cytology. Am J Clin Nutri 60:293–298

    CAS  Google Scholar 

  • Goodman DS (1984) Vitamin A and retinoids in health and disease. N Engl J Med 16:271–315

    Google Scholar 

  • Goh Y, Koren G (2008) Folic acid in pregnancy and fetal outcomes. Obstet Gynaecol 3:3–13

    Google Scholar 

  • Gregory JF 3rd (1993) Ascorbic acid bioavailability in foods and supplements. Nut Rev 51(10):301–303

    Google Scholar 

  • Harding AE, Muller DPR, Thomas PK, Willison HJ (1982) Spinocerebellar degeneration secondary to chronic intestinal malabsorption: a vitamin E syndrome. Ann Neuro 12:419–424

    Article  CAS  Google Scholar 

  • Haurani FI (1973) Vitamin B12 and the megaloblastic development. Science 182:78

    Article  PubMed  CAS  Google Scholar 

  • Hussey GD, Klein M (1990) A randomized controlled trial of vitamin A in children with severe measles. N Engl Med 323:160–164

    Article  CAS  Google Scholar 

  • Inua M, Duggan MB, West CE (1983) Post-measles corneal ulceration in Northern Nigeria: the role of vitamin A, malnutrition, and measles. Ann Trop Paediatr 3:181–191

    PubMed  CAS  Google Scholar 

  • Lucas A, Bates C (1984) transient Riboflavin depletion in preterm infants. Arch Dis Child 59:837–841

    Article  PubMed  CAS  Google Scholar 

  • McCandless DW, Schenker S (1969) Neurologic disorders of thiamine deficiency. Nutr Rev 27:213

    PubMed  CAS  Google Scholar 

  • Melhorn DK, Gross (1971) Vitamin E dependent anaemia in the premature infant. Relationship between gestational age and absorption of Vitamin E. J Paediatr 79:581

    Article  CAS  Google Scholar 

  • Peto R, Doll R, Buckley JD, Sporn MB (1981) Can dietary beta carotene materially reduce human cancer rates? Nature 290:201–208

    Article  PubMed  CAS  Google Scholar 

  • Reddy V (1991) Control of vitamin A and blindness. Acta Paediatr Scand Supplement 12:419–424

    Google Scholar 

  • Rillotson JA, Baker EM (1972) An enzymatic measurement of riboflavin status in man. Am J Clin Nutr 25:425

    Google Scholar 

  • Rojers LE, Porter FS, Sidbery JB Jr (1969) Thiamine responsive megaloblastic anaemia. J Paediatr 74:494

    Article  Google Scholar 

  • Scriver CR (1976) Vitamin B6 deficiency and dependency in man. Am J Dis Child 113:109

    Google Scholar 

  • Sommer A (1995) Magintude and distribution of the problem. In: Alfred Sommer (ed) Vitamin A deficiency and its consequences: a field guide to detection and control, vol 70, 3rd edn. Geneva, WHO, pp 225–232

    Google Scholar 

  • Suharno D, West CE, Muhilal B et al (1992 Dec) Cross sectional study on the iron and Vitamin A status of pregnant women in West Java, Indonesia. Am J Clin Nutr 56(6):988–993

    PubMed  CAS  Google Scholar 

  • Stange L, Carlstrom K, Eriksson M (1978) Hypervitaminosis A in early human pregnancy and malformations of the central nervous system. Acta Obstet Gynecol Scand 57:289–291

    Article  PubMed  CAS  Google Scholar 

  • Traber MG (2007) Vitamin E regularity mechanisms. Anu Rev Nutr 27:347–368

    Article  CAS  Google Scholar 

  • Tripp JH, Candy DCA (1992) Manual of paediatric gastroenterology and nutrition, 2nd edn. Butterworth-Heinemann, Oxford

    Google Scholar 

  • Vijaya Raghavan K, Rahhaiah G, Prakasam BS et al (1990) Effect of massive dose of vitamin A on morbidity and mortality in Indian children. Lancet 336:1342–1344

    Article  CAS  Google Scholar 

  • WHO, USAID (1976) Vitamin A and Xerophthalmia, vol 590. WHO, Geneva

    Google Scholar 

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Correspondence to Gaafar I. Suliman MBBS, FRCP(Lon), FRCPCH(Lon),DCH(Lon) .

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Suliman, G.I., Nazer, H.M. (2012). Vitamin Deficiencies and Excess. In: Elzouki, A.Y., Harfi, H.A., Nazer, H.M., Stapleton, F.B., Oh, W., Whitley, R.J. (eds) Textbook of Clinical Pediatrics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02202-9_57

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  • DOI: https://doi.org/10.1007/978-3-642-02202-9_57

  • Publisher Name: Springer, Berlin, Heidelberg

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