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Chemotherapy

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Book cover Pediatric Oncology Nursing

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

In the 1940s, following the effects of mustard gas during World War I, nitrogen mustard was introduced as part of the treatment for childhood cancer. Prior to this time, surgery and radiation therapy were the only treatments available. Rapid anticancer drug development followed and continues into the twenty-first century. Since the introduction of chemotherapy, overall 5-year survival rate for childhood cancers has increased from near 0% to near 90% in some childhood malignancies (Ries et al. 2008). Success is in part due to refinement of the existing chemotherapy agents and administration guidelines coupled with advancement in surgical, radiotherapy, and imaging techniques. Today, targeted therapy is at the forefront of preclinical and clinical investigations. While advancement in all areas pushes survivorship curves upward, challenges continue to drive investigators to find a cure for all childhood cancers with minimal acute and long-term toxicity.

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Author information

Authors and Affiliations

  1. Dana Farber Cancer Institute, Boston, MA, USA

    Christine Chordas & Kristen Graham

Authors
  1. Christine Chordas
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  2. Kristen Graham
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Editors and Affiliations

  1. Dip Cancer Nursing, Child Health Evaluative Sciences, Hospital for Sick Children, Child Health Evaluative, Toronto, ON, Canada

    Deborah Tomlinson

  2. Department of Nursing, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Nancy E. Kline (Director, Research and Evidence-Based Practice) (Director, Research and Evidence-Based Practice)

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© 2010 Springer-Verlag Berlin Heidelberg

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Chordas, C., Graham, K. (2010). Chemotherapy. In: Tomlinson, D., Kline, N.E. (eds) Pediatric Oncology Nursing. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87984-8_9

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  • DOI: https://doi.org/10.1007/978-3-540-87984-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-87983-1

  • Online ISBN: 978-3-540-87984-8

  • eBook Packages: MedicineMedicine (R0)

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