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Drug-Induced Retinal Toxicity

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Atlas of Inherited Retinal Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1085))

Abstract

  • Drug-induced retinal toxicity can occur from the use of systemic, intravitreal, or topical medications. Despite the presence of the blood-ocular barrier, the retina is vulnerable to toxic effects of systemic medications leading to dysfunction and retinal degeneration.

  • These toxicities can be categorized as damage to the retinal pigment epithelium (RPE) and photoreceptor complex, vascular damage, ganglion cell or optic nerve damage, cystoid macular edema, crystalline retinopathy, uveitis, changes in color vision and electroretinography (ERG), and other miscellaneous effects.

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Suggested Reading

  • Di Nicola M, Barteselli G, Dell’Arti L, Ratiglia R, Viola F. Functional and structural abnormalities in deferoxamine retinopathy: a review of the literature. Biomed Res Int. 2015;2015:249617.

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Author information

Authors and Affiliations

  1. Jonas Children’s Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Stephen H. Tsang

  2. Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, NewYork-Presbyterian Hospital, New York, NY, USA

    Stephen H. Tsang & Tarun Sharma

Authors
  1. Stephen H. Tsang
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  2. Tarun Sharma
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Corresponding author

Correspondence to Tarun Sharma .

Editor information

Editors and Affiliations

  1. Jonas Children’s Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons Columbia University, New York, NY, USA

    Stephen H. Tsang

  2. Department of Ophthalmology, Edward S. Harkness Eye Institute NewYork-Presbyterian Hospital Columbia University, New York, NY, USA

    Tarun Sharma

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Cite this chapter

Tsang, S.H., Sharma, T. (2018). Drug-Induced Retinal Toxicity. In: Tsang, S., Sharma, T. (eds) Atlas of Inherited Retinal Diseases. Advances in Experimental Medicine and Biology, vol 1085. Springer, Cham. https://doi.org/10.1007/978-3-319-95046-4_48

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