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Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates

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Book cover Targeting the DNA Damage Response for Anti-Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

ATR inhibitors are a new class of anti-cancer compounds reaching early phase clinical trials. They are predicted to have anti-cancer activity as monotherapy, and in combination with DNA damaging chemotherapies and ionizing radiation. We outline the clinical trials in progress using the current clinical candidates VX-970 (M6620) and AZD6738, discuss potential biomarkers for this class of drug and consider future avenues for development of ATR inhibitors.

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Authors and Affiliations

  1. The Institute of Cancer Research, London, UK

    Magnus T. Dillon & Kevin J. Harrington

  2. The Royal Marsden NHS Foundation Trust, London, UK

    Magnus T. Dillon & Kevin J. Harrington

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  1. Vertex Pharmaceuticals (Europe) Ltd, Abingdon, Oxfordshire, United Kingdom

    John Pollard

  2. Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    Nicola Curtin

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Dillon, M.T., Harrington, K.J. (2018). Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates. In: Pollard, J., Curtin, N. (eds) Targeting the DNA Damage Response for Anti-Cancer Therapy. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-75836-7_5

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