Skip to main content

Pericardial Diseases

  • Chapter
  • First Online:
Book cover Case-Based Textbook of Echocardiography

Abstract

The pericardium is a thin fibroelastic sac, comprised of both a serous visceral and fibrous parietal layer, which surrounds the heart and the great vessels. Echocardiography remains the initial imaging modality of choice and should be performed as a complete study or as a point of care when suspecting acute pericarditis. Presence of an abnormal septal motion from right to left in early diastole during inspiration, the presence of a plethoric IVC and dilated hepatic veins, and evidence of ventricular interdependence are the cornerstones of constrictive pericarditis physiology. Annulus paradoxus and annulus reversus are also strong indicators of constrictive pericarditis. The location, size, extent of the pericardial effusion and presence of loculations should be characterized using all four echocardiographic windows including PSLAX, PSAX, Apical, and the Subcostal views. Chamber collapse is an important indicator of the presence of tamponade physiology along with a septal bulge and peak mitral and tricuspid E-inflow velocity respiratory variation. Most cases of cardiac tamponade are treated with a pericardiocentesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

2D:

Two dimensional

3D:

Three dimensional

ASA:

Aspirin

CMR:

Cardiac magnetic resonance

CP:

Constrictive pericarditis

CRP:

C-reactive protein

EF:

Ejection fraction

E:

Peak E-wave velocity of the mitral valve (cm/sec)

e′:

TDI of the mitral annulus

EKG:

Electrocardiogram

IVC:

Inferior vena cava

LA:

Left atrium

LV:

Left ventricular

LVEF:

Left ventricular ejection fraction

NSAID:

Non-steroidal anti-inflammatory drug

PSLAX:

Parasternal long axis

PSAX:

Parasternal short axis

RV:

Right ventricle

STE:

Speckle-tracking echocardiography

TDI:

Tissue Doppler imaging

TEE:

Transesophageal echocardiography

TTE:

Transthoracic echocardiography

References

  1. Spodick DH. The normal and diseased pericardium: current concepts of pericardial physiology, diagnosis and treatment. J Am Coll Cardiol. 1983;1(1):240–51.

    Article  CAS  PubMed  Google Scholar 

  2. Miyazaki T, Pride HP, Zipes DP. Prostaglandins in the pericardial fluid modulate neural regulation of cardiac electrophysiological properties. Circ Res. 1990;66(1):163–75.

    Article  CAS  PubMed  Google Scholar 

  3. Holt JP. The normal pericardium. Am J Cardiol. 1970;26(5):455–65.

    Article  CAS  PubMed  Google Scholar 

  4. Spodick DH. Macrophysiology, microphysiology, and anatomy of the pericardium: a synopsis. Am Heart J. 1992;124(4):1046–51.

    Article  CAS  PubMed  Google Scholar 

  5. Khandaker MH, et al. Pericardial disease: diagnosis and management. Mayo Clin Proc. 2010;85(6):572–93.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Kyto V, Sipila J, Rautava P. Clinical profile and influences on outcomes in patients hospitalized for acute pericarditis. Circulation. 2014;130(18):1601–6.

    Article  PubMed  Google Scholar 

  7. Klein AL, et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2013;26(9):965–1012.e15.

    Article  PubMed  Google Scholar 

  8. Maisch B, et al. Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European society of cardiology. Eur Heart J. 2004;25(7):587–610.

    Article  PubMed  Google Scholar 

  9. Adler Y, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015;36(42):2921–64.

    Article  PubMed  Google Scholar 

  10. Cosyns B, et al. European Association of Cardiovascular Imaging (EACVI) position paper: multimodality imaging in pericardial disease. Eur Heart J Cardiovasc Imaging. 2015;16(1):12–31.

    Article  PubMed  Google Scholar 

  11. Imazio M, Gaita F, LeWinter M. Evaluation and treatment of pericarditis: a systematic review. JAMA. 2015;314(14):1498–506.

    Article  CAS  PubMed  Google Scholar 

  12. Imazio M, Adler Y. Management of pericardial effusion. Eur Heart J. 2013;34(16):1186–97.

    Article  PubMed  Google Scholar 

  13. Sagrista-Sauleda J, Merce AS, Soler-Soler J. Diagnosis and management of pericardial effusion. World J Cardiol. 2011;3(5):135–43.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Spodick DH. Acute pericarditis: current concepts and practice. JAMA. 2003;289(9):1150–3.

    Article  PubMed  Google Scholar 

  15. Lange RA, Hillis LD. Clinical practice acute pericarditis. N Engl J Med. 2004;351(21):2195–202.

    Article  CAS  PubMed  Google Scholar 

  16. Lotrionte M, et al. International collaborative systematic review of controlled clinical trials on pharmacologic treatments for acute pericarditis and its recurrences. Am Heart J. 2010;160(4):662–70.

    Article  CAS  PubMed  Google Scholar 

  17. Imazio M, et al. Individualized therapy for pericarditis. Expert Rev Cardiovasc Ther. 2009;7(8):965–75.

    Article  CAS  PubMed  Google Scholar 

  18. Imazio M, et al. Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) trial. Arch Intern Med. 2005;165(17):1987–91.

    Article  CAS  PubMed  Google Scholar 

  19. Imazio M, et al. Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial. Circulation. 2005;112(13):2012–6.

    Article  CAS  PubMed  Google Scholar 

  20. Imazio M, et al. Corticosteroids for recurrent pericarditis: high versus low doses: a nonrandomized observation. Circulation. 2008;118(6):667–71.

    Article  CAS  PubMed  Google Scholar 

  21. Pelliccia A, et al. Recommendations for participation in competitive sport and leisure-time physical activity in individuals with cardiomyopathies, myocarditis and pericarditis. Eur J Cardiovasc Prev Rehabil. 2006;13(6):876–85.

    Article  PubMed  Google Scholar 

  22. Seidenberg PH, Haynes J. Pericarditis: diagnosis, management, and return to play. Curr Sports Med Rep. 2006;5(2):74–9.

    Article  PubMed  Google Scholar 

  23. Imazio M, et al. Indicators of poor prognosis of acute pericarditis. Circulation. 2007;115(21):2739–44.

    Article  PubMed  Google Scholar 

  24. Syed FF, Schaff HV, Oh JK. Constrictive pericarditis—a curable diastolic heart failure. Nat Rev Cardiol. 2014;11(9):530–44.

    Article  PubMed  Google Scholar 

  25. Mayosi BM. Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa. Heart. 2007;93(10):1176–83.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Bertog SC, et al. Constrictive pericarditis: etiology and cause-specific survival after pericardiectomy. J Am Coll Cardiol. 2004;43(8):1445–52.

    Article  PubMed  Google Scholar 

  27. Welch TD, et al. Echocardiographic diagnosis of constrictive pericarditis: Mayo Clinic criteria. Circ Cardiovasc Imaging. 2014;7(3):526–34.

    Article  PubMed  Google Scholar 

  28. Veress G, et al. Mitral and tricuspid annular velocities before and after pericardiectomy in patients with constrictive pericarditis. Circ Cardiovasc Imaging. 2011;4(4):399–407.

    Article  PubMed  Google Scholar 

  29. Oh JK, et al. Diagnostic role of Doppler echocardiography in constrictive pericarditis. J Am Coll Cardiol. 1994;23(1):154–62.

    Article  CAS  PubMed  Google Scholar 

  30. Garcia MJ, et al. Differentiation of constrictive pericarditis from restrictive cardiomyopathy: assessment of left ventricular diastolic velocities in longitudinal axis by Doppler tissue imaging. J Am Coll Cardiol. 1996;27(1):108–14.

    Article  CAS  PubMed  Google Scholar 

  31. Sohn DW, et al. Unique features of early diastolic mitral annulus velocity in constrictive pericarditis. J Am Soc Echocardiogr. 2004;17(3):222–6.

    Article  PubMed  Google Scholar 

  32. Ha JW, et al. Differentiation of constrictive pericarditis from restrictive cardiomyopathy using mitral annular velocity by tissue Doppler echocardiography. Am J Cardiol. 2004;94(3):316–9.

    Article  PubMed  Google Scholar 

  33. Reuss CS, et al. Using mitral ‘annulus reversus’ to diagnose constrictive pericarditis. Eur J Echocardiogr. 2009;10(3):372–5.

    Article  PubMed  Google Scholar 

  34. Choi JH, et al. Mitral and tricuspid annular velocities in constrictive pericarditis and restrictive cardiomyopathy correlation with pericardial thickness on computed tomography. JACC Cardiovasc Imaging. 2011;4(6):567–75.

    Article  PubMed  Google Scholar 

  35. Lu XF, et al. Diagnosis of constrictive pericarditis by quantitative tissue Doppler imaging. Int J Cardiol. 2009;137(1):22–8.

    Article  PubMed  Google Scholar 

  36. Sengupta PP, et al. Disparate patterns of left ventricular mechanics differentiate constrictive pericarditis from restrictive cardiomyopathy. JACC Cardiovasc Imaging. 2008;1(1):29–38.

    Article  PubMed  Google Scholar 

  37. Kusunose K, et al. Biventricular mechanics in constrictive pericarditis comparison with restrictive cardiomyopathy and impact of pericardiectomy. Circ Cardiovasc Imaging. 2013;6(3):399–406.

    Article  PubMed  Google Scholar 

  38. Zagol B, et al. Effusive constrictive pericarditis: 2D, 3D echocardiography and MRI imaging. Echocardiography. 2007;24(10):1110–4.

    Article  PubMed  Google Scholar 

  39. Ling LH, et al. Pericardial thickness measured with transesophageal echocardiography: feasibility and potential clinical usefulness. J Am Coll Cardiol. 1997;29(6):1317–23.

    Article  CAS  PubMed  Google Scholar 

  40. Haley JH, et al. Transient constrictive pericarditis: causes and natural history. J Am Coll Cardiol. 2004;43(2):271–5.

    Article  PubMed  Google Scholar 

  41. Sagrista-Sauleda J, et al. Transient cardiac constriction: an unrecognized pattern of evolution in effusive acute idiopathic pericarditis. Am J Cardiol. 1987;59(9):961–6.

    Article  CAS  PubMed  Google Scholar 

  42. Hancock EW. A clearer view of effusive-constrictive pericarditis. N Engl J Med. 2004;350(5):435–7.

    Article  CAS  PubMed  Google Scholar 

  43. Sagrista-Sauleda J, et al. Effusive-constrictive pericarditis. N Engl J Med. 2004;350(5):469–75.

    Article  CAS  PubMed  Google Scholar 

  44. Baker CM, Orsinelli DA. Subacute effusive-constrictive pericarditis: diagnosis by serial echocardiography. J Am Soc Echocardiogr. 2004;17(11):1204–6.

    Article  PubMed  Google Scholar 

  45. Troughton RW, Asher CR, Klein AL. Pericarditis. Lancet. 2004;363(9410):717–27.

    Article  PubMed  Google Scholar 

  46. Weitzman LB, et al. The incidence and natural history of pericardial effusion after cardiac surgery—an echocardiographic study. Circulation. 1984;69(3):506–11.

    Article  CAS  PubMed  Google Scholar 

  47. Scohy TV, et al. Three-dimensional transesophageal echocardiography: diagnosing the extent of pericarditis constrictiva and intraoperative surgical support. J Card Surg. 2009;24(3):305–8.

    Article  PubMed  Google Scholar 

  48. Veress G, Feng D, Oh JK. Echocardiography in pericardial diseases: new developments. Heart Fail Rev. 2013;18(3):267–75.

    Article  PubMed  Google Scholar 

  49. Fardman A, et al. European guidelines on pericardial diseases: a focused review of novel aspects. Curr Cardiol Rep. 2016;18(5):46.

    Article  PubMed  Google Scholar 

  50. Sagrista-Sauleda J, et al. Clinical clues to the causes of large pericardial effusions. Am J Med. 2000;109(2):95–101.

    Article  CAS  PubMed  Google Scholar 

  51. Boltwood CM Jr. Ventricular performance related to transmural filling pressure in clinical cardiac tamponade. Circulation. 1987;75(5):941–55.

    Article  PubMed  Google Scholar 

  52. Spodick DH. Acute cardiac tamponade. N Engl J Med. 2003;349(7):684–90.

    Article  PubMed  Google Scholar 

  53. Spodick DH. Threshold of pericardial constraint: the pericardial reserve volume and auxiliary pericardial functions. J Am Coll Cardiol. 1985;6(2):296–7.

    Article  CAS  PubMed  Google Scholar 

  54. D'Cruz IA, et al. Two-dimensional echocardiography in cardiac tamponade occurring after cardiac surgery. J Am Coll Cardiol. 1985;5(5):1250–2.

    Article  CAS  PubMed  Google Scholar 

  55. Gillam LD, et al. Hydrodynamic compression of the right atrium: a new echocardiographic sign of cardiac tamponade. Circulation. 1983;68(2):294–301.

    Article  CAS  PubMed  Google Scholar 

  56. Hoit BD, Fowler NO. Influence of acute right ventricular dysfunction on cardiac tamponade. J Am Coll Cardiol. 1991;18(7):1787–93.

    Article  CAS  PubMed  Google Scholar 

  57. Hoit BD, Gabel M, Fowler NO. Cardiac tamponade in left ventricular dysfunction. Circulation. 1990;82(4):1370–6.

    Article  CAS  PubMed  Google Scholar 

  58. Hoit BD, Shaw D. The paradoxical pulse in tamponade: mechanisms and echocardiographic correlates. Echocardiography. 1994;11(5):477–87.

    Article  CAS  PubMed  Google Scholar 

  59. Cogswell TL, et al. Total peripheral resistance during cardiac tamponade: adrenergic and angiotensin roles. Am J Phys. 1986;251(5 Pt 2):R916–22.

    CAS  Google Scholar 

  60. Tsang TS, Oh JK, Seward JB. Diagnosis and management of cardiac tamponade in the era of echocardiography. Clin Cardiol. 1999;22(7):446–52.

    Article  CAS  PubMed  Google Scholar 

  61. Merce J, et al. Correlation between clinical and Doppler echocardiographic findings in patients with moderate and large pericardial effusion: implications for the diagnosis of cardiac tamponade. Am Heart J. 1999;138(4 Pt 1):759–64.

    Article  CAS  PubMed  Google Scholar 

  62. Leeman DE, Levine MJ, Come PC. Doppler echocardiography in cardiac tamponade: exaggerated respiratory variation in transvalvular blood flow velocity integrals. J Am Coll Cardiol. 1988;11(3):572–8.

    Article  CAS  PubMed  Google Scholar 

  63. Appleton CP, Hatle LK, Popp RL. Superior vena cava and hepatic vein Doppler echocardiography in healthy adults. J Am Coll Cardiol. 1987;10(5):1032–9.

    Article  CAS  PubMed  Google Scholar 

  64. Martins JB, et al. Comparative effects of catecholamines in cardiac tamponade: experimental and clinical studies. Am J Cardiol. 1980;46(1):59–66.

    Article  CAS  PubMed  Google Scholar 

  65. Reddy PS, et al. Cardiac tamponade: hemodynamic observations in man. Circulation. 1978;58(2):265–72.

    Article  CAS  PubMed  Google Scholar 

  66. Cogswell TL, et al. The shift in the relationship between intrapericardial fluid pressure and volume induced by acute left ventricular pressure overload during cardiac tamponade. Circulation. 1986;74(1):173–80.

    Article  CAS  PubMed  Google Scholar 

  67. Pepi M, et al. Pericardial effusion after cardiac surgery: incidence, site, size, and haemodynamic consequences. Br Heart J. 1994;72(4):327–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Buchanan CL, et al. Pericardiocentesis with extended catheter drainage: an effective therapy. Ann Thorac Surg. 2003;76(3):817–20.

    Article  PubMed  Google Scholar 

  69. Rafique AM, et al. Frequency of recurrence of pericardial tamponade in patients with extended versus nonextended pericardial catheter drainage. Am J Cardiol. 2011;108(12):1820–5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vartan Mardigyan MD, FRCPC .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Chetrit, M., Mardigyan, V. (2018). Pericardial Diseases. In: Sadeghpour, A., Alizadehasl, A. (eds) Case-Based Textbook of Echocardiography. Springer, Cham. https://doi.org/10.1007/978-3-319-67691-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67691-3_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67689-0

  • Online ISBN: 978-3-319-67691-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics