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Osteocardiology: Endochondral Bone Formation

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Abstract

Osteoblastogenesis is the molecular regulation of bone formation in the skeleton. Parallel risk factors for atherosclerosis and osteoporosis have emerged as the initiating factors for both disease processes. As bone formation decreases in the skeleton, it increases in the heart. This chapter outlines the parallel phenotype as bone forms in the heart while leaving the skeleton, to identify the osteogenic phenotype. Over time, this process may be reversed in both organs, as identification and targeting of the pathways allows for clinical therapies to modify and slow progression of this disease.

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Authors and Affiliations

  1. Most Sacred Heart of Jesus Cardiology and Valvular Institute, Sheboygan, Wisconsin, USA

    Nalini M. Rajamannan

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  1. Nalini M. Rajamannan
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Rajamannan, N.M. (2018). Osteocardiology: Endochondral Bone Formation. In: Osteocardiology. Springer, Cham. https://doi.org/10.1007/978-3-319-64994-8_5

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  • DOI: https://doi.org/10.1007/978-3-319-64994-8_5

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