Overview
- Provides thorough, comprehensive discussion of the topic with enough breadth to appeal to scientists, clinicians and those doing research for drug discovery
- Contributors contribute worldwide expertise and perspective and are all leaders in their fields
- Illustrations and tables throughout enhance and complement the text
Part of the book series: Cell Death in Biology and Diseases (CELLDEATH)
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Table of contents (11 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecul
es, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.Editors and Affiliations
About the editors
Dr. Wen-Xing Ding is an Associate Professor of Department of Pharmacology, Toxicology and Therapeutics at The University of Kansas Medical Center. He received his Ph.D. from the National University of Singapore. He did his Postdoctoral training at University of Pittsburgh. In the past decade, Dr. Ding’s research has been focused on the molecular mechanisms of cell death and autophagy in alcohol and drug-induced liver injury as well as liver tumorigenesis. Dr. Ding is a member of American Association of Studies of Liver Disease (AASLD), Society of Toxicology (SOT) and Research society of Alcoholism. Dr. Ding was a Liver Scholar of American Liver Foundation and a recipient of University Scholarly Achievement Award. Dr. Ding has published more than 100 papers in peer-reviewed journals and his research work is currently supported by NIAAA and NIDDK.
Dr. Xiao-Ming Yin is the Louis Y. Mazzini Professor of Pathology at the Department of Pathology and Laboratory Medicine,
Indiana University School of Medicine. Â He obtained his medical degree from Shanghai Medical University and his PhD degree from University of Texas Southwestern Medical Center at Dallas. Â He completed his post-doctoral fellow training and his pathology residency training at Washington University in St. Louis. Dr. Yin is a member of several scientific societies and is a fellow of American Association of Studies of Liver Disease (AASLD). He has won the Outstanding Investigator Award from American Society for Investigative Pathology (ASIP). His research interest is the cell death and survival in tissue injury and cancer biology, particularly in the liver system. ÂBibliographic Information
Book Title: Molecules, Systems and Signaling in Liver Injury
Editors: Wen-Xing Ding, Xiao-Ming Yin
Series Title: Cell Death in Biology and Diseases
DOI: https://doi.org/10.1007/978-3-319-58106-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-58105-7Published: 14 August 2017
Softcover ISBN: 978-3-319-86322-1Published: 12 August 2018
eBook ISBN: 978-3-319-58106-4Published: 02 August 2017
Series ISSN: 2625-2902
Series E-ISSN: 2625-2899
Edition Number: 1
Number of Pages: XV, 290
Number of Illustrations: 5 b/w illustrations, 20 illustrations in colour
Topics: Cell Cycle Analysis, Apoptosis, Cell Physiology, Hepatology, Membrane Biology