Abstract
Many factors govern the toxicological feature of silica-coated magnetic nanoparticles and they are associated with intrinsic features of the nanoparticles and also cell type. In vitro studies on cells and in vivo experiments trend to reveal the biocompatibility of silica and magnetite in the nano-scale.
The knowledge about toxicology of magnetic silica nanoparticles is intended not only to ensure safety of new devices intended for biomedical purposes such as drug targeting and delivery, but also as a tool for therapeutic insights if nanoparticles are present in selective toxicity. Thus, it is important to evaluate toxicological features associated with each novel nanodevice. This chapter describes the mechanisms associated with the toxicology of nano-silica, iron oxide magnetic nanoparticles, and the effects of the combination of the magnetic core with silica in different types of cells as well as the impact in vivo in different animals. All the aspects that govern toxicity are carefully considered and described to provide a global knowledge about the effect on the whole organism.
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Castranova, V., & Vallyathan, V. (2000). Silicosis and coal workers’ pneumoconiosis. Environmental Health Perspectives, 108(Suppl 4), 675.
Saffiotti, U. (1991). Lung cancer induction by crystalline silica. Progress in Clinical and Biological Research, 374, 51–69.
Chen, M., & von Mikecz, A. (2005). Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Experimental Cell Research, 305(1), 51–62.
Champoux, J. J. (2001). DNA topoisomerases: Structure, function, and mechanism. Annual Review of Biochemistry, 70(1), 369–413.
Lin, W., Huang, Y. W., Zhou, X. D., & Ma, Y. (2006). In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicology and Applied Pharmacology, 217(3), 252–259.
Abuhijleh, A. L., & Khalaf, J. (2010). Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase–mimetic activities. European Journal of Medicinal Chemistry, 45(9), 3811–3817.
Chang, J. S., Chang, K. L. B., Hwang, D. F., & Kong, Z. L. (2007). In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environmental Science & Technology, 41(6), 2064–2068.
Park, E. J., & Park, K. (2009). Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicology Letters, 184(1), 18–25.
Nishimori, H., Kondoh, M., Isoda, K., Tsunoda, S. I., Tsutsumi, Y., & Yagi, K. (2009). Silica nanoparticles as hepatotoxicants. European Journal of Pharmaceutics and Biopharmaceutics, 72(3), 496–501.
Xie, G., Sun, J., Zhong, G., Shi, L., & Zhang, D. (2010). Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Archives of Toxicology, 84(3), 183–190.
Yu, T., Malugin, A., & Ghandehari, H. (2011). Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nano, 5(7), 5717–5728.
Yu, T., Greish, K., McGill, L. D., Ray, A., & Ghandehari, H. (2012). Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: Their vasculature effect and tolerance threshold. ACS Nano, 6(3), 2289–2301.
Morris, A. S., Adamcakova-Dodd, A., Lehman, S. E., Wongrakpanich, A., Thorne, P. S., Larsen, S. C., et al. (2016). Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs. Toxicology Letters, 241, 207–215.
Hall, J. E. (2015). Guyton and Hall textbook of medical physiology. Philadelphia, PA: Elsevier Health Sciences.
Anzai, Y., Piccoli, C. W., Outwater, E. K., Stanford, W., Bluemke, D. A., Nurenberg, P., et al. (2003). Evaluation of neck and body metastases to nodes with ferumoxtran 10-enhanced MR imaging: Phase III safety and efficacy study 1. Radiology, 228(3), 777–788.
Boyer, C., Whittaker, M. R., Bulmus, V., Liu, J., & Davis, T. P. (2010). The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications. NPG Asia Materials, 2(1), 23–30.
Solanki, A., Kim, J. D., & Lee, K. B. (2008). Nanotechnology for regenerative medicine: Nanomaterials for stem cell imaging. Nanomedicine, 3(4), 567–578.
Markides, H., Rotherham, M., & El Haj, A. J. (2012). Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine. Journal of Nanomaterials, 2012, 13.
Moore, A., Marecos, E., Bogdanov, A., Jr., & Weissleder, R. (2000). Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model 1. Radiology, 214(2), 568–574.
Mahmoudi, M., Hofmann, H., Rothen-Rutishauser, B., & Petri-Fink, A. (2011). Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles. Chemical Reviews, 112(4), 2323–2338.
Kim, J. S., Yoon, T. J., Yu, K. N., Kim, B. G., Park, S. J., Kim, H. W., et al. (2006). Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicological Sciences, 89(1), 338–347.
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Agotegaray, M.A., Lassalle, V.L. (2017). Toxicological Insights. In: Silica-coated Magnetic Nanoparticles. SpringerBriefs in Molecular Science. Springer, Cham. https://doi.org/10.1007/978-3-319-50158-1_7
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DOI: https://doi.org/10.1007/978-3-319-50158-1_7
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