Skip to main content
SpringerLink
Log in

Insomnia in Patients with Comorbid Medical Problems

  • Chapter
  • First Online:
Clinical Handbook of Insomnia

Part of the book series: Current Clinical Neurology ((CCNEU))

  • 2614 Accesses

Abstract

Almost every medical disease can be associated with insomnia. Insomnia may result directly from the pathophysiology of the illness, as a consequence of pain or other disease symptoms, as an unintended side effect of treatment, or as a manifestation of the anxiety and uncertainty attached to the diagnosis. Improving sleep quality often requires optimally managing other disease symptoms and selecting medications that minimize adverse side effects. Importantly, many medical conditions and medications alter the risks and symptoms of intrinsic sleep disorders that can present as insomnia and sleep fragmentation. Conversely some hypnotics can affect medical conditions. As patients with medical comorbidities tend to be older and take multiple medications, they are also at an increased risk for adverse drug reactions. Non-pharmacologic treatments for insomnia should be given special consideration in this population.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cesari M, Prince M, Thiyagarajan JA, De Carvalho IA, Bernabei R, Chan P, et al. Frailty: an emerging public health priority. J Am Med Dir Assoc. 2016;17(3):188–92.

    Article  PubMed  Google Scholar 

  2. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.

    Article  CAS  PubMed  Google Scholar 

  3. Willson MN, Greer CL, Weeks DL. Medication regimen complexity and hospital readmission for an adverse drug event. Ann Pharmacother. 2014;48(1):26–32.

    Article  PubMed  Google Scholar 

  4. Wimmer BC, Bell JS, Fastbom J, Wiese MD, Johnell K. Medication regimen complexity and polypharmacy as factors associated with all-cause mortality in older people: a population-based cohort study. Ann Pharmacother. 2016;50(2):89–95.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Charlesworth CJ, Smit E, Lee DSH, Alramadhan F, Odden MC. Polypharmacy among adults aged 65 years and older in the United States: 1988–2010. J Gerontol A Biol Sci Med Sci. 2015;70(8):989–95.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2013;13(1):57–65.

    Article  PubMed  Google Scholar 

  7. Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4(5):487–504.

    PubMed  PubMed Central  Google Scholar 

  8. Geiger-Brown JM, Rogers VE, Liu W, Ludeman EM, Downton KD, Diaz-Abad M. Cognitive behavioral therapy in persons with comorbid insomnia: meta-analysis. Sleep Med Rev. 2015;23:54–67.

    Article  PubMed  Google Scholar 

  9. Wu JQ, Appleman ER, Salazar RD, Ong JC. Cognitive behavioral therapy for insomnia comorbid with psychiatric and medical conditions: a meta-analysis. JAMA Intern Med. 2015;175(9):1461–72.

    Article  PubMed  Google Scholar 

  10. Murphy SL, Xu J, Kochanek KD. National vital statistics reports. National Vital Statistics Reports 61.4; 2013. http://www.nber.org/mortality/2007/nvsr58_19.pdf.

  11. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2015;133(4):e38–360.

    Article  PubMed  Google Scholar 

  12. Malhotra A, Loscalzo J. Sleep and cardiovascular disease: an overview. Prog Cardiovasc Dis. 2009;51(4):279–84.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel B, Bush AJ. Comorbidity of chronic insomnia with medical problems. Sleep. 2007;30(2):5–10.

    Google Scholar 

  14. Hartz AJ, Daly JM, Kohatsu ND, Stromquist AM, Jogerst GJ, Kukoyi OA. Risk factors for insomnia in a rural population. Ann Epidemiol. 2007;17(12):940–7.

    Article  PubMed  Google Scholar 

  15. Kales J, Kales A. Evaluation, diagnosis, and treatment of clinical condtions related to sleep. JAMA. 1970;213(13):2229–35.

    Article  CAS  PubMed  Google Scholar 

  16. Schiza SE, Simantirakis E, Bouloukaki I, Mermigkis C, Arfanakis D, Chrysostomakis S, et al. Sleep patterns in patients with acute coronary syndromes. Sleep Med. 2010;11(2):149–53.

    Article  PubMed  Google Scholar 

  17. Leineweber C, Kecklund G, Janszky I, Åkerstedt T, Orth-Gomér K. Poor sleep increases the prospective risk for recurrent events in middle-aged women with coronary disease. J Psychosom Res. 2003;54(2):121–7.

    Article  PubMed  Google Scholar 

  18. Nagai M, Hoshide S, Kario K. Sleep duration as a risk factor for cardiovascular disease—a review of the recent literature. Curr Cardiol Rev. 2010;6(1):54–61.

    Article  PubMed  PubMed Central  Google Scholar 

  19. MacDonald M, Fang J, Pittman SD, White DP, Malhotra A. The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta-blockers. J Clin Sleep Med. 2008;4(1):38–42.

    PubMed  PubMed Central  Google Scholar 

  20. Butt M, Dwivedi G, Khair O, Lip GYH. Obstructive sleep apnea and cardiovascular disease. Int J Cardiol. 2010;139(1):7–16.

    Article  PubMed  Google Scholar 

  21. Arzt M, Young T, Finn L, Skatrud JB, Ryan CM, Newton GE, et al. Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med. 2006;166(16):1716–22.

    Article  PubMed  Google Scholar 

  22. Hanly PJ, Zuberi-Khokhar N. Periodic limb movements during sleep in patients with congestive heart failure. Chest. 1996;109(6):1497–502.

    Article  CAS  PubMed  Google Scholar 

  23. Skomro R, Silva R, Alves R, Figueiredo A, Lorenzi-Filho G. The prevalence and significance of periodic leg movements during sleep in patients with congestive heart failure. Sleep Breath. 2009;13(1):43–7.

    Article  PubMed  Google Scholar 

  24. Rosen D, Roux FJ, Shah N. Sleep and breathing in congestive heart failure. Clin Chest Med. 2014;35:521–34.

    Article  PubMed  Google Scholar 

  25. Laugsand LE, Vatten LJ, Platou C, Janszky I. Insomnia and the risk of acute myocardial infarction: a population study. Circulation. 2011;124(19):2073–81.

    Article  PubMed  Google Scholar 

  26. Sivertsen B, Lallukka T, Salo P, Pallesen S, Hysing M, Krokstad S, et al. Insomnia as a risk factor for ill health: results from the large population-based prospective HUNT Study in Norway. J Sleep Res. 2014;23(2):124–32.

    Article  PubMed  Google Scholar 

  27. Javaheri S. Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study. Am J Respir Crit Care Med. 2006;173(2):234–7.

    Article  CAS  PubMed  Google Scholar 

  28. Van Den Heuvel CJ, Reid KJ, Dawson D. Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin. Physiol Behav. 1997;61(6):795–802.

    Article  Google Scholar 

  29. Stoschitzky K, Stoschitzky G, Brussee H, Bonell C, Dobnig H. Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol. Cardiology. 2006;106:199–206.

    Article  CAS  PubMed  Google Scholar 

  30. Brismar K, Hylander B, Eliasson K, Rössner S, Wetterberg L. Melatonin secretion related to side-effects of beta-blockers from the central nervous system. Acta Med Scand. 1988;223(6):525–30.

    Article  CAS  PubMed  Google Scholar 

  31. Scheer FAJL, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, et al. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012;35(10):1395–402.

    PubMed  PubMed Central  Google Scholar 

  32. Reiter RJ, Tan D-X, Paredes SD, Fuentes-Broto L. Beneficial effects of melatonin in cardiovascular disease. Ann Med. 2010;42(4):276–85.

    Article  CAS  PubMed  Google Scholar 

  33. Tuccori M, Montagnani S, Mantarro S, Capogrosso-Sansone A, Ruggiero E, Saporiti A, et al. Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management. CNS Drugs. 2014;28(3):249–72.

    Article  CAS  PubMed  Google Scholar 

  34. Hamer M, David Batty G, Seldenrijk A, Kivimaki M. Antidepressant medication use and future risk of cardiovascular disease: the Scottish Health Survey. Eur Heart J. 2011;32(4):437–42.

    Article  CAS  PubMed  Google Scholar 

  35. Redeker NS, Jeon S, Andrews L, Cline J, Jacoby D, Mohsenin V. Feasibility and efficacy of a self-management intervention for insomnia in stable heart failure. J Clin Sleep Med. 2015;11(10):1109–19. http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=30210.

  36. Bradley TD, Floras JS. Sleep apnea and heart failure: part I: obstructive sleep apnea. Circulation. 2003;107(12):1671–8.

    Article  PubMed  Google Scholar 

  37. Bradley TD, Logan AG, Kimoff RJ, Sériès F, Morrison D, Ferguson K, et al. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med. 2005;353(19):2025–33.

    Article  CAS  PubMed  Google Scholar 

  38. Cowie M, Woehrle H. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med. 2015;373(12):1095–105. http://www.nejm.org/doi/full/10.1056/NEJMoa1506459.

  39. Milioli G, Bosi M, Poletti V, Tomassetti S, Grassi A, Riccardi S, et al. Sleep and respiratory sleep disorders in idiopathic pulmonary fibrosis. Sleep Med Rev. 2016;26:57–63. doi:10.1016/j.smrv.2015.03.005.

  40. Caverley PM. The effect of oxygenation on sleep quality in chronic bronchitis and emphysema. Am Rev Respir Dis. 1982;126(2):206–10.

    Google Scholar 

  41. Fauroux B, Pepin J-L, Boelle P-Y, Cracowski C, Murris-Espin M, Nove-Josserand R, et al. Sleep quality and nocturnal hypoxaemia and hypercapnia in children and young adults with cystic fibrosis. Arch Dis Child. 2012;97(11):960–6.

    Article  PubMed  Google Scholar 

  42. Budhiraja R, Parthasarathy S, Budhiraja P, Habib MP, Wendel C, Quan SF. Insomnia in patients with COPD. Sleep. 2012;35(3):369–75.

    PubMed  PubMed Central  Google Scholar 

  43. Ohayon MM. Chronic Obstructive Pulmonary Disease and its association with sleep and mental disorders in the general population. J Psychiatr Res. 2014;54:79–84.

    Article  PubMed  Google Scholar 

  44. Valipour A, Lavie P, Lothaller H, Mikulic I, Burghuber OC. Sleep profile and symptoms of sleep disorders in patients with stable mild to moderate chronic obstructive pulmonary disease. Sleep Med. 2011;12(4):367–72.

    Article  PubMed  Google Scholar 

  45. Wertz DA, Pollack M, Rodgers K, Bohn RL, Sacco P, Sullivan SD. Impact of asthma control on sleep, attendance at work, normal activities, and disease burden. Ann Allergy Asthma Immunol. 2010;105(2):118–23.

    Article  PubMed  Google Scholar 

  46. Durrington HJ, Farrow SN, Loudon AS, Ray DW. The circadian clock and asthma. Thorax. 2014;69(1):90–2.

    Article  PubMed  Google Scholar 

  47. Mehra R. Understanding nocturnal asthma. The plot thickens. Am J Respir Crit Care Med. 2014;190(3):243–4.

    Google Scholar 

  48. Budhiraja R, Siddiqi TA, Quan SF. Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management. J Clin Sleep Med. 2015;11(3):259–70.

    PubMed  PubMed Central  Google Scholar 

  49. Roth T. Hypnotic use for insomnia management in chronic obstructive pulmonary disease. Sleep Med. 2009;10(1):19–25.

    Article  PubMed  Google Scholar 

  50. Berthon-Jones M, Sullivan CE. Ventilatory and arousal responses to hypoxia in sleeping humans. Am Rev Respir Dis. 1982;125:632–9.

    CAS  PubMed  Google Scholar 

  51. Berthon-Jones M, Sullivan CE. Ventilation and arousal responses to hypercapnia in normal sleeping humans. J Appl Physiol Respir Environ Exerc Physiol. 1984;57:59–67.

    CAS  PubMed  Google Scholar 

  52. Wood JM. Prevalence of nightmares among patients with asthma and chronic obstructive airways disease. Am Phys Assoc. 1993;3(4):231–41.

    Google Scholar 

  53. Ciriaco M, Ventrice P, Russo G, Scicchitano M, Mazzitello G, Scicchitano F, et al. Corticosteroid-related central nervous system side effects. J Pharmacol Pharmacother. 2013;4 Suppl 1:S94–8.

    PubMed  PubMed Central  Google Scholar 

  54. Curtis JR, Westfall AO, Allison J, Bijlsma JW, Freeman A, George V, et al. Population-based assessment of adverse events associated with long-term glucocorticoid use. Arthritis Rheum. 2006 Jun 15;55(3):420–6.

    Google Scholar 

  55. Alavoine L, Taillé C, Ball J, Knauer C, Witte S, Kent J, et al. Nocturnal asthma: proof-of-concept open-label study with delayed-release prednisone. Pulm Ther. 2015;1(1):43–52.

    Article  Google Scholar 

  56. Berry RB, Desa MM, Branum JP, Light RW. Effect of theophylline on sleep and sleep-disordered breathing in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1991;143(2):245–50.

    Article  CAS  PubMed  Google Scholar 

  57. McNicholas WT, Calverley PMA, Lee A, Edwards JC, Williams A, Rees J, et al. Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD. Eur Respir J. 2004;23(6):825–31.

    Article  CAS  PubMed  Google Scholar 

  58. Martin RJ, Bucki Bartclson BL, Smith P, Hudgel DW, Lewis D, Pohl G, et al. Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD. Chest. 1999;115(5):1338–45.

    Article  CAS  PubMed  Google Scholar 

  59. Lo Coco D, Mattaliano A, Lo Coco A, Randisi B. Increased frequency of restless legs syndrome in chronic obstructive pulmonary disease patients. Sleep Med. 2009;10(5):572–6.

    Article  PubMed  Google Scholar 

  60. Aras G, Kadakal F, Purisa S, Kanmaz D, Aynaci A, Isik E. Are we aware of restless legs syndrome in COPD patients who are in an exacerbation period? Frequency and probable factors related to underlying mechanism. COPD. 2011;8(6):437–43.

    Article  PubMed  Google Scholar 

  61. Cavalcante AGM, de Bruin PFC, de Bruin VMS, Pereira EDB, Cavalcante MM, Nunes DM, et al. Restless legs syndrome, sleep impairment, and fatigue in chronic obstructive pulmonary disease. Sleep Med. 2012;13(7):842–7.

    Article  PubMed  Google Scholar 

  62. Jolly E, Aguirre L, Jorge E, Luna C. Acute effect of lorazepam on respiratory muscles in stable patients with chronic obstructive pulmonary disease. Medicina (B Aires). 1996;56(5 Pt 1):472–8.

    Google Scholar 

  63. Cohn MA, Morris DD, Juan D. Effects of estazolam and flurazepam on cardiopulmonary function in patients with chronic obstructive pulmonary disease. Drug Saf. 1992;7(2):152–8.

    Google Scholar 

  64. Stege G, Heijdra YF, van den Elshout FJJ, van de Ven MJT, de Bruijn PJ, van Sorge AA, et al. Temazepam 10 mg does not affect breathing and gas exchange in patients with severe normocapnic COPD. Respir Med. 2010;104(4):518–24.

    Article  PubMed  Google Scholar 

  65. Berry RB, Patel PB. Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea. Sleep. 2006;29(8):1052–6.

    Google Scholar 

  66. Beaupré A, Soucy R, Phillips R, Bourgouin J. Respiratory center output following zopiclone or diazepam administration in patients with pulmonary disease. Respiration. 1988;54:235–40.

    Google Scholar 

  67. Shilo L, Dagan Y, Smorjik Y, Weinberg U, Dolev S, Komptel B, et al. Effect of melatonin on sleep quality of COPD intensive care patients: a pilot study. Chronobiol Int. 2000;17:71–6.

    Google Scholar 

  68. Nunes DM, Mota RMS, Mochado MO, Pereira EDB, deBruin VMS, deBruin PFC. Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease. Braz J Med Biol Res. 2008;41(10):926–31.

    Article  CAS  PubMed  Google Scholar 

  69. Kryger M, Wang-Weigand S, Zhang J, Roth T. Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD. Sleep Breath. 2008;12:243–50.

    Google Scholar 

  70. Matos Cavalcante AG, Bruin PFC, Bruin VMS, Nunes DM, Pereira EDB, Cavalcante MM. Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. J Pineal Res. 2012;53:238–44.

    Google Scholar 

  71. Kapella MC, Herdegen JJ, Perlis ML, Shaver JL, Larson JL, Law JA, et al. Cognitive behavioral therapy for insomnia comorbid with COPD is feasible with preliminary evidence of positive sleep and fatigue effects. Int J Chron Obstruct Pulmon Dis. 2011;6:625–35.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Koch BCP, Nagtegaal JE, Kerkhof GA, ter Wee PM. Circadian sleep-wake rhythm disturbances in end-stage renal disease. Nat Rev Nephrol. 2009;5(7):407–16.

    Article  PubMed  Google Scholar 

  73. De Santo RM, Bartiromo M, Cesare CM, Cirillo M. Sleep disorders occur very early in chronic kidney disease. J Nephrol. 2008;21 Suppl 13:S59–65.

    PubMed  Google Scholar 

  74. Koch BCP, Van Der Putten K, Van Someren EJW, Wielders JPM, Ter Wee PM, Nagtegaal JE, et al. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrol Dial Transplant. 2010;52:513–9.

    Google Scholar 

  75. Sabbatini M, Minale B, Crispo A, Pisani A, Ragosta A, Esposito R, et al. Insomnia in maintenance haemodialysis patients. Nephrol Dial Transplant. 2002;17(5):852–6.

    Article  PubMed  Google Scholar 

  76. Eryavuz N, Yuksel S, Acarturk G, Uslan I, Demir S, Demir M, et al. Comparison of sleep quality between hemodialysis and peritoneal dialysis patients. Int Urol Nephrol. 2008;40(3):785–91.

    Article  PubMed  Google Scholar 

  77. Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer MA, et al. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant. 2003;18(1):126–32.

    Article  PubMed  Google Scholar 

  78. Novak M, Molnar MZ, Ambrus C, Kovacs AZ, Koczy A, Remport A, et al. Chronic insomnia in kidney transplant recipients. Am J Kidney Dis. 2006;74:655–65.

    Google Scholar 

  79. Chavoshi F, Einollahi B, Sadeghniat Haghighi K, Saraei M, Izadianmehr N. Prevalence and sleep related disorders of restless leg syndrome in hemodialysis patients. Nephrourol Mon. 2015;7(2):e24611.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Calviño J, Cigarrán S, Lopez LM, Martinez A, Sobrido M-J. Restless legs syndrome in non-dialysis renal patients: is it really that common? J Clin Sleep Med. 2015;11(1):57–60.

    PubMed  PubMed Central  Google Scholar 

  81. Sloand JA, Shelly MA, Feigin A, Bernstein P, Monk RD. A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis. 2004;43(4):663–70.

    Article  CAS  PubMed  Google Scholar 

  82. Jaber BL, Schiller B, Burkart JM, Daoui R, Kraus MA, Lee Y, et al. Impact of short daily hemodialysis on restless legs symptoms and sleep disturbances. Clin J Am Soc Nephrol. 2011;6(5):1049–56.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Giannaki CD, Hadjigeorgiou GM, Karatzaferi C, Maridaki MD, Koutedakis Y, Founta P, et al. A single-blind randomized controlled trial to evaluate the effect of 6 months of progressive aerobic exercise training in patients with uraemic restless legs syndrome. Nephrol Dial Transplant. 2013;28(11):2834–40.

    Article  PubMed  Google Scholar 

  84. Redolfi S, Yumino D, Ruttanaumpawan P, Yau B, Su M-C, Lam J, et al. Relationship between overnight rostral fluid shift and Obstructive Sleep Apnea in nonobese men. Am J Respir Crit Care Med. 2009;179(3):241–6.

    Article  PubMed  Google Scholar 

  85. Elias RM, Bradley TD, Kasai T, Motwani SS, Chan CT. Rostral overnight fluid shift in end-stage renal disease: relationship with obstructive sleep apnea. Nephrol Dial Transplant. 2012;27(4):1569–73.

    Article  PubMed  Google Scholar 

  86. Elias RM, Chan CT, Paul N, Motwani SS, Kasai T, Gabriel JM, et al. Relationship of pharyngeal water content and jugular volume with severity of obstructive sleep apnea in renal failure. Nephrol Dial Transplant. 2013;28(4):937–44.

    Article  CAS  PubMed  Google Scholar 

  87. Lyons OD, Chan CT, Yadollahi A, Bradley TD. Effect of ultrafiltration on sleep apnea and sleep structure in patients with end-stage renal disease. Am J Respir Crit Care Med. 2015;191(11):1287–94.

    Article  PubMed  Google Scholar 

  88. Tang SCW, Lam B, Lai ASH, Pang CBY, Tso WK, Khong PL, et al. Improvement in sleep apnea during nocturnal peritoneal dialysis is associated with reduced airway congestion and better uremic clearance. Clin J Am Soc Nephrol. 2009;4(2):410–8.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Virga G, Stanic L, Mastrosimone S, Gastaldon F, da Porto A, Bonadonna A. Hypercalcemia and insomnia in hemodialysis patients. Nephron. 2000;85(1):94–5.

    Article  CAS  PubMed  Google Scholar 

  90. Koch BCP, Hagen EC, Nagtegaal JE, Boringa JBS, Kerkhof GA, Ter Wee PM. Effects of nocturnal hemodialysis on melatonin rhythm and sleep-wake behavior: an uncontrolled trial. Am J Kidney Dis. 2009;53(4):658–64.

    Article  CAS  PubMed  Google Scholar 

  91. Koch BCP, Nagtegaal JE, Hagen EC, ter Wee PM, Kerkhof GA. Different melatonin rhythms and sleep-wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis. Sleep Med. 2010;11(3):242–6.

    Article  PubMed  Google Scholar 

  92. Sabbatini M, Crispo A, Pisani A, Ragosta A, Cesaro A, Mirenghi F, Cianciaruso B, Federico S. Zaleplon improves sleep quality in maintenance hemodialysis patients. Nephron Clin Pract. 2003;94(4):c99–103.

    Google Scholar 

  93. Edalat-Nejad M, Haqhverdi F, Hossein-Tabar T, Ahmadian M. Melatonin improves sleep quality in hemodialysis patients. Indian J Nephrol. 2013;23(4):264–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Chen HY, Chiang CK, Wang HH, Hung KY, Lee YJ, Peng YS, et al. Cognitive-behavioral therapy for sleep disturbance in patients undergoing peritoneal dialysis: a pilot randomized controlled trial. Am J Kidney Dis. 2008;52:314–23.

    Google Scholar 

  95. Shaker R, Castell DO, Schoenfeld PS, Spechler SJ. Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am J Gastroenterol. 2003;98:1487–93.

    Google Scholar 

  96. Moore JG, Englert E. Circadian rhythm of gastric acid secretion in man. Nature. 1970;226:1261–2.

    Google Scholar 

  97. Shaheen NJ, Madanick RD, Alattar M, Morgan DR, Davis PH, Galanko JA, et al. Gastroesophageal reflux disease as an etiology of sleep disturbance in subjects with insomnia and minimal reflux symptoms: a pilot study of prevalence and response to therapy. Dig Dis Sci. 2008;53:1493–9.

    Google Scholar 

  98. Johnson DA, Orr WC, Crawley JA, Traxler B, McCullough J, Brown KA, et al. Effect of esomeprazole on nighttime heartburn and sleep quality in patients with GERD: a randomized, placebo-controlled trial. Am J Gastroenterol. 2005;11:1914–22.

    Google Scholar 

  99. Fass R, Johnson DA, Orr WC, Han C, Mody R, Stern KN, et al. The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERD. Am J Gastroenterol. 2011;106:421–31.

    Google Scholar 

  100. Heinemann S, Graf KI, Karaus M, Dorow P. Occurrence of obstructive sleep related respiratory disorder in conjunction with gastroesophageal reflux. Pneumologie. 1995;49:139–41.

    Google Scholar 

  101. Eskiizmir G, Kezirian E. Is there a vicious cycle between obstructive sleep apnea and laryngopharyngeal reflux disease? Med Hypotheses. 2009;73(5):706–8.

    Article  PubMed  Google Scholar 

  102. Green BT, Broughton WA, O’Connor JB. Marked improvement in nocturnal gastroesophageal reflux in a large cohort of patients with obstructive sleep apnea treated with continuous positive airway pressure. Arch Intern Med. 2003;163:41–5.

    Google Scholar 

  103. Senior BA et al. Gastroesophageal reflux and obstructive sleep apnea. Laryngoscope. 2001;111(12):2144–6.

    Article  CAS  PubMed  Google Scholar 

  104. Rotem AY, Sperber AD, Krugliak P, Freidman B, Tal A, Tarasiuk A. Polysomnographic and actigraphic evidence of sleep fragmentation in patients with irritable bowel syndrome. Sleep. 2003;26:747–52.

    Google Scholar 

  105. Song GH, Leng PH, Gwee KA, Moochhala SM, Ho KY. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. Gut. 2005;54:1402–7.

    Google Scholar 

  106. Córdoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei AT. High prevalence of sleep disturbance in cirrhosis. Hepatology. 1998;27(2):339–45.

    Article  PubMed  Google Scholar 

  107. Groeneweg M, Quero JC, De Bruijn I, Hartmann IJC, Essink-Bot ML, Hop WCJ, et al. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology. 1998;28(1):45–9.

    Article  CAS  PubMed  Google Scholar 

  108. Chojnacki C, Wachowska-Kelly P, Błasiak J, Reiter RJ, Chojnacki J. Melatonin secretion and metabolism in patients with hepatic encephalopathy. J Gastroenterol Hepatol. 2013;28(2):342–7.

    Article  CAS  PubMed  Google Scholar 

  109. Velissaris D, Karamouzos V, Polychronopoulos P, Karanikolas M. Chronotypology and melatonin alterations in minimal hepatic encephalopathy. J Circadian Rhythms. 2009;7:6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  110. Fass R, Quan SF, O’Connor GT, Ervin A, Iber C. Predictors of heartburn during sleep in a large prospective cohort study. Chest. 2005;127(5):1658–66.

    Article  PubMed  Google Scholar 

  111. Hall AW, Moossa AR, Clark J, Cooley GR, Skinner DB. The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man. Gut. 1975 May;16(5):347–52.

    Google Scholar 

  112. Gagliardi GS, Shah AP, Goldstein M, Denua-Rivera S, Doghramji K, Cohen S, et al. Effect of zolpidem on the sleep arousal response to nocturnal esophageal acid exposure. Clin Gastroenterol Hepatol. 2009;7(9):948–52.

    Article  CAS  PubMed  Google Scholar 

  113. Kandil TS, Mousa AA, El-Gendy AA, Abbas AM. The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. BMC Gastroenterol. 2010;10:7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  114. de Oliveira Torres JDF, de Souza Pereira R. Which is the best choice for gastroesophageal disorders: Melatonin or proton pump inhibitors? World J Gastrointest Pharmacol Ther. 2010;1(5):102–6.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Jha LK, Fass R, Gadam R, Maradey-Romero C, Nasrollah L, Hershcovici T, Quan SF, Dickman R. The Effect of Ramelteon on Heartburn Symptoms of Patients With Gastroesophageal Reflux Disease and Chronic Insomnia: A Pilot Study. J Clin Gastroenterol. 2016;50(2):e19–24.

    Google Scholar 

  116. Lane EA, Moss HB. Pharmacokinetics of melatonin in man: first pass hepatic metabolism. J Clin Endocrinol Metab. 1985;61(6):1214–6.

    Article  CAS  PubMed  Google Scholar 

  117. Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK. Nocturia and disturbed sleep in the elderly. Sleep Med. 2009;10:540–8.

    Google Scholar 

  118. Leger D, Comet D, Haab F, Ohayon MM. Prostatic hyperplasia is highly associated with nocturia and excessive sleepiness: a cross-sectional study Emmanuel Chartier-Kastler. BMJ Open. 2012;2:e000505.

    Google Scholar 

  119. Simaioforidis V, Papatsoris AG, Chrisofos M, Chrisafis M, Koritsiadis S, Deliveliotis C. Tamsulosin versus transurethral resection of the prostate: effect on nocturia as a result of benign prostatic hyperplasia. Int J Urol. 2011;18(3):243–8.

    Article  PubMed  Google Scholar 

  120. Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20:327–36.

    Google Scholar 

  121. Rackley R, Weiss JP, Rovner ES, Wang JT, Guan Z, 037 STUDY GROUP. Nighttime dosing with tolterodine reduces overactive bladder-related nocturnal micturitions in patients with overactive bladder and nocturia. Urology. 2006;67(4):731–6.

    Google Scholar 

  122. Diefenbach K, Donath F, Maurer A, Quispe Bravo S, Wernecke KD, Schwantes U, et al. Randomised, double-blind study of the effects of oxybutynin, tolterodine, trospium chloride and placebo on sleep in healthy young volunteers. Clin Drug Investig. 2003;23:395–404.

    Google Scholar 

  123. Kemmer H, Mathes AM, Dilk O, Gröschel A, Grass C, Stöckle M. Obstructive sleep apnea syndrome is associated with overactive bladder and urgency incontinence in men. Sleep. 2009;32(2):271–5.

    PubMed  PubMed Central  Google Scholar 

  124. Lose G, Lalos O, Freeman RM, Van Kerrebroeck P. Efficacy of desmopressin (Minirin) in the treatment of nocturia: a double-blind placebo-controlled study in women. Am J Obstet Gynecol. 2003;189:1106–13.

    Google Scholar 

  125. Hospital S. Efficacy of desmopressin in the treatment of nocturia: a double-blind placebo-controlled study in men. BJU Int. 2002;89:855–62.

    Google Scholar 

  126. Morgan D, Tsai SC. Sleep and the endocrine system. Crit Care Clin. 2015;31(3):403–18.

    Article  PubMed  Google Scholar 

  127. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999;354(9188):1435–9.

    Article  CAS  PubMed  Google Scholar 

  128. Lu CL, Lee YC, Tsai SJ, Hu PG, Sim CB. Psychiatric disturbances associated with hyperthyroidism: an analysis report of 30 cases. Zhonghua Yi Xue Za Zhi (Taipei). 1995;56(6):393–8.

    CAS  Google Scholar 

  129. Moffett SX, Giannopoulos PF, James TD, Martin JV. Effects of acute microinjections of thyroid hormone to the preoptic region of hypothyroid adult male rats on sleep, motor activity and body temperature. Brain Res. 2013;1516:55–65.

    Article  CAS  PubMed  Google Scholar 

  130. Sridhar GR, Putcha V, Lakshmi G. Sleep in thyrotoxicosis. Indian J Endocrinol Metab. 2011;15(1):23–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  131. Tobaldini E, Porta A, Bulgheroni M, Pecis M, Muratori M, Bevilacqua M, et al. Increased complexity of short-term heart rate variability in hyperthyroid patients during orthostatic challenge. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1988–91. doi:10.1109/IEMBS.2008.4649579.

  132. Kraemer S, Danker-Hopfe H, Pilhatsch M, Bes F, Bauer M. Effects of supraphysiological doses of levothyroxine on sleep in healthy subjects: a prospective polysomnography study. J Thyroid Res. 2011;2011:420580.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  133. Akatsu H, Ewing SK, Stefanick ML, Fink HA, Stone KL, Barrett-Connor E, et al. Association between thyroid function and objective and subjective sleep quality in older men: the osteoporotic fractures in men (MrOS) study. Endocr Pract. 2014;20(6):576–86.

    Article  PubMed  PubMed Central  Google Scholar 

  134. Colao A, Ferone D, Marzullo P, Lombardi G. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev. 2004;25(1):102–52.

    Article  CAS  PubMed  Google Scholar 

  135. Grunstein RR. Sleep apnea in acromegaly. Ann Intern Med. 1991;115(7):527.

    Article  CAS  PubMed  Google Scholar 

  136. Roemmler J, Gutt B, Fischer R, Vay S, Wiesmeth A, Bidlingmaier M, et al. Elevated incidence of sleep apnoea in acromegaly-correlation to disease activity. Sleep Breath. 2012;16(4):1247–53.

    Article  CAS  PubMed  Google Scholar 

  137. Grunstein RR, Ho KY, Berthon-Jones M, Stewart D, Sullivan CE. Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. Am J Respir Crit Care Med. 1994;150(2):496–502.

    Article  CAS  PubMed  Google Scholar 

  138. Grunstein RR. Effect of octreotide, a somatostatin analog, on sleep apnea in patients with acromegaly. Ann Intern Med. 1994;121(7):478.

    Article  CAS  PubMed  Google Scholar 

  139. Aulinas A, Webb SM. Health-related quality of life in primary and secondary adrenal insufficiency. Expert Rev Pharmacoecon Outcomes Res. 2014 Dec;14(6):873–88.

    Google Scholar 

  140. Løvås K, Husebye ES, Holsten F, Bjorvatn B. Sleep disturbances in patients with Addison’s disease. Eur J Endocrinol. 2003;148(4):449–56.

    Article  PubMed  Google Scholar 

  141. Voss U, Tuin I, Krakow K. Sleep improvement in an insomniac patient with global pituitary insufficiency after change from triple to quadruple cortisol replacement therapy. Sleep Med. 2007;8(5):517–9.

    Article  PubMed  Google Scholar 

  142. García-Borreguero D, Wehr TA, Larrosa O, Granizo JJ, Hardwick D, Chrousos GP, et al. Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency. J Clin Endocrinol Metab. 2000;85(11):4201–6.

    PubMed  Google Scholar 

  143. Shipley JE, Schteingart DE, Tandon R, Starkman MN. Sleep architecture and sleep apnea in patients with Cushing’s disease. Sleep. 1992;15(6):514–8.

    CAS  PubMed  Google Scholar 

  144. Berger G, Hardak E, Shaham B, Avitan E, Yigla M. Preliminary prospective explanatory observation on the impact of 3-month steroid therapy on the objective measures of sleep-disordered breathing. Sleep Breath. 2012;16(2):549–53.

    Article  PubMed  Google Scholar 

  145. Bercea RM, Mihaescu T, Cojocaru C, Bjorvatn B. Fatigue and serum testosterone in obstructive sleep apnea patients. Clin Respir J. 2015;9(3):342–9.

    Article  CAS  PubMed  Google Scholar 

  146. Hanafy HM. Testosterone therapy and obstructive sleep apnea: is there a real connection? J Sex Med. 2007;4(5):1241–6.

    Article  CAS  PubMed  Google Scholar 

  147. Hoyos CM, Killick R, Yee BJ, Grunstein RR, Liu PY. Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2012;77(4):599–607.

    Article  CAS  Google Scholar 

  148. Xu Q, Lang C. Examining the relationship between subjective sleep disturbance and menopause: a systematic review and meta-analysis. Menopause. 2014;21(12):1301–18.

    Google Scholar 

  149. Takahashi JS, Hong H-K, Ko CH, McDearmon EL. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008;9(10):764–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  150. Paul KN, Saafir TB, Tosini G. The role of retinal photoreceptors in the regulation of circadian rhythms. Rev Endocr Metab Disord. 2009;10(4):271–8.

    Article  PubMed  PubMed Central  Google Scholar 

  151. Ho Mien I, Chua EC-P, Lau P, Tan L-C, Lee IT-G, Yeo S-C, et al. Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction. PLoS One. 2014;9(5):e96532.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  152. Tabandeh H, Lockley SW, Buttery R, Skene DJ, Defrance R, Arendt J, et al. Disturbance of sleep in blindness. Am J Ophthalmol. 1998;126:707–12.

    Google Scholar 

  153. Kessel L, Lundeman JH, Herbst K, Andersen TV, Larsen M. Age-related changes in the transmission properties of the human lens and their relevance to circadian entrainment. J Cataract Refract Surg. 2010;36:308–12.

    Google Scholar 

  154. Kessel L, Siganos G, Jørgensen T, Larsen M. Sleep disturbances are related to decreased transmission of blue light to the retina caused by lens yellowing. Sleep. 2011;34(9):1215–9.

    PubMed  PubMed Central  Google Scholar 

  155. Turner PL, Van Someren EJW, Mainster MA. The role of environmental light in sleep and health: effects of ocular aging and cataract surgery. Sleep Med Rev. 2010;14:269–80.

    Google Scholar 

  156. Tanaka M, Hosoe K, Hamada T, Morita T. Change in sleep state of the elderly before and after cataract surgery. J Physiol Anthropol. 2010;29(6):219–24.

    Article  PubMed  Google Scholar 

  157. Asplund R, Lindblad BE. Sleep and sleepiness 1 and 9 months after cataract surgery. Arch Gerontol Geriatr. 2004;38(1):69–75.

    Article  CAS  PubMed  Google Scholar 

  158. Asplund R, Ejdervik LB. The development of sleep in persons undergoing cataract surgery. Arch Gerontol Geriatr. 2002;35(2):179–87.

    Article  CAS  PubMed  Google Scholar 

  159. Ayaki M, Muramatsu M, Negishi K, Tsubota K. Improvements in sleep quality and gait speed after cataract surgery. Rejuvenation Res. 2013;16(1):35–42.

    Article  PubMed  PubMed Central  Google Scholar 

  160. Mainster MA, Turner PL. Blue-blocking IOLs decrease photoreception without providing significant photoprotection. Surv Ophthalmol. 2010;55:272–83.

    Google Scholar 

  161. Landers JA, Tamblyn D, Perriam D. Effect of a blue-light-blocking intraocular lens on the quality of sleep. J Cataract Refract Surg. 2009;35:83–8.

    Google Scholar 

  162. Sack RL, Lewy AJ, Blood ML, Keith LD, Nakagawa H. Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. J Clin Endocrinol Metab. 1992;75:127–34.

    Google Scholar 

  163. Sack RL, Brandes RW, Kendall AR, Lewy AJ. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med. 2000;343(15):1070–7.

    Google Scholar 

  164. Lockley S, Dressman M, Torres R, Lavedan C, Licamele L, Polymeropoulos M. Tasimelteon treatment entrains the circadian clock and demonstrates significant benefit on sleep and wake parameters in totally blind individuals with non-24 hour circadian rhythms. Sleep Med. 2013;14(Supplement 1):e178.

    Google Scholar 

  165. Fishbein AB, Vitaterna O, Haugh IM, Bavishi AA, Zee PC, Turek FW, et al. Nocturnal eczema: review of sleep and circadian rhythms in children with atopic dermatitis and future research directions. J Allergy Clin Immunol. 2015;136(5):1170–7.

    Article  PubMed  Google Scholar 

  166. Gupta MA, Gupta AK. Sleep-wake disorders and dermatology. Clin Dermatol. 2013;31(1):118–26.

    Article  PubMed  Google Scholar 

  167. Goh C-L, Khoo L. A retrospective study of the clinical presentation and outcome of herpes zoster in a tertiary dermatology outpatient referral clinic. Int J Dermatol. 1997;36(9):667–72.

    Article  CAS  PubMed  Google Scholar 

  168. Camfferman D, Kennedy JD, Gold M, Martin AJ, Winwood P, Lushington K. Eczema, sleep, and behavior in children. J Clin Sleep Med. 2010;6(6):581–8.

    PubMed  PubMed Central  Google Scholar 

  169. Silverberg J, Garg N, Paller A. Sleep disturbances in adults with eczema are associated with impaired overall health: a US population-based study. J Invest Dermatol. 2015;135(1):56–66.

    Google Scholar 

  170. Bender BG, Ballard R, Canono B, Murphy JR, Leung DYM. Disease severity, scratching, and sleep quality in patients with atopic dermatitis. J Am Acad Dermatol. 2008;58(3):415–20.

    Article  PubMed  Google Scholar 

  171. Kimata H. Viewing humorous film improves night-time wakening in children with atopic dermatitis. Indian Pediatr. 2007;44(4):281–5.

    Google Scholar 

  172. Kenna HA, Poon AW, de los Angeles CP, Koran LM. Psychiatric complications of treatment with corticosteroids: review with case report. Psychiatry Clin Neurosci. 2011;65(6):549–60.

    Article  CAS  PubMed  Google Scholar 

  173. Richardson GS, Roehrs TA, Rosenthal L, Koshorek G, Roth T. Tolerance to daytime sedative effects of H1 antihistamines. J Clin Psychopharmacol. 2002;22(5):511–5.

    Article  CAS  PubMed  Google Scholar 

  174. Krystal AD, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, et al. Efficacy and safety of doxepin 1 mg and 3 mg in a 12-week sleep laboratory and outpatient trial of elderly subjects with chronic primary insomnia. Sleep. 2010;33(11):1553–61.

    PubMed  PubMed Central  Google Scholar 

  175. Yeung W-F, Chung K-F, Yung K-P, Ng TH-Y. Doxepin for insomnia: a systematic review of randomized placebo-controlled trials. Sleep Med Rev. 2015;19:75–83.

    Article  PubMed  Google Scholar 

  176. Savard J, Morin CM. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19:895–908.

    Google Scholar 

  177. Chen M-L, Chang H-K. Physical symptom profiles of depressed and nondepressed patients with cancer. Palliat Med. 2004;18:712–8.

    Google Scholar 

  178. Palesh OG, Roscoe JA, Mustian KM, Roth T, Savard J, Ancoli-Israel S, et al. Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program. J Clin Oncol. 2010;28:292–8.

    Google Scholar 

  179. Hickok JT, Morrow GR, Roscoe JA, Mustian K, Okunieff P. Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer. J Pain Symptom Manage. 2005;30(5):433–42.

    Article  PubMed  Google Scholar 

  180. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P, Lin H-M, et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 2002;51:887–92.

    Google Scholar 

  181. Sprod L, Palesh O, Janelsins M, Peppone L, Heckler C, Adams M, et al. Exercise, sleep quality, and mediators of sleep in breast and prostate cancer patients receiving radiation therapy. Commun Oncol. 2010;7:463–71.

    Google Scholar 

  182. Miaskowski C, Lee KA. Pain, fatigue, and sleep disturbances in oncology outpatients receiving radiation therapy for bone metastasis: a pilot study. J Pain Symptom Manage. 1999;17:320–32.

    Google Scholar 

  183. Nelson JE, Meier DE, Oei EJ, Nierman DM, Senzel RS, Manfredi PL, et al. Self-reported symptom experience of critically ill cancer patients receiving intensive care. Crit Care Med. 2001;29(2):277–82.

    Google Scholar 

  184. Savard J, Simard S, Blanchet J, Ivers H, Morin CM. Prevalence, clinical characteristics, and risk factors for insomnia in the context of breast cancer. Sleep. 2001;24(5):583–90.

    CAS  PubMed  Google Scholar 

  185. Savard J, Ivers H, Villa J, Caplette-Gingras A, Morin CM. Natural course of insomnia comorbid with cancer: an 18-month longitudinal study. J Clin Oncol. 2011;29:3580–6.

    Google Scholar 

  186. Fleming L, MacMahon K. CBT-I in cancer: we know it works, so why are we waiting? Curr Sleep Med Rep. 2015;1(3):177–83.

    Article  Google Scholar 

  187. Garland SN, Johnson JA, Savard J, Gehrman P, Perlis M, Carlson L, et al. Sleeping well with cancer: a systematic review of cognitive behavioral therapy for insomnia in cancer patients. Neuropsychiatr Dis Treat. 2014;10:1113–24.

    PubMed  PubMed Central  Google Scholar 

  188. Espie CA, Fleming L, Cassidy J, Samuel L, Taylor LM, White CA, et al. Randomized controlled clinical effectiveness trial of cognitive behavior therapy compared with treatment as usual for persistent insomnia in patients with cancer. J Clin Oncol. 2008;26:4651–8.

    Article  PubMed  Google Scholar 

  189. Morin CM, Bootzin RR, Buysse DJ, Edinger JD, Espie CA, Lichstein KL. Psychological and behavioral treatment of insomnia: update of the recent evidence (1998–2004). Sleep. 2006;29(11):1398–414.

    PubMed  Google Scholar 

  190. Savard J, Ivers H, Savard M-H, Morin CM. Long-term effects of two formats of cognitive behavioral therapy for insomnia comorbid with breast cancer. Sleep. 2015;39(4):813–23.

    Google Scholar 

  191. Heckler CE, Garland SN, Peoples AR, Perlis ML, Shayne M, Morrow GR, et al. Cognitive behavioral therapy for insomnia, but not armodafinil, improves fatigue in cancer survivors with insomnia: a randomized placebo-controlled trial. Support Care Cancer. 2015;24(5):2059–66.

    Google Scholar 

  192. Lengacher CA, Johnson-Mallard V, Post-White J, Moscoso MS, Jacobsen PB, Klein TW, et al. Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer. Psychooncology. 2009;18(12):1261–72.

    Article  PubMed  Google Scholar 

  193. Lengacher CA, Reich RR, Paterson CL, Jim HS, Ramesar S, Alinat CB, et al. The effects of mindfulness-based stress reduction on objective and subjective sleep parameters in women with breast cancer: a randomized controlled trial. Psychooncology. 2015;24(4):424–32.

    Article  PubMed  Google Scholar 

  194. Johns SA, Brown LF, Beck-Coon K, Monahan PO, Tong Y, Kroenke K. Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors. Psychooncology. 2015;24(8):885–93.

    Article  PubMed  Google Scholar 

  195. Ledesma D, Kumano H. Mindfulness-based stress reduction and cancer: a meta-analysis. Psychooncology. 2009;18(6):571–9.

    Article  PubMed  Google Scholar 

  196. Andersen SR, Würtzen H, Steding-Jessen M, Christensen J, Andersen KK, Flyger H, et al. Effect of mindfulness-based stress reduction on sleep quality: results of a randomized trial among Danish breast cancer patients. Acta Oncol. 2013;52(2):336–44.

    Article  PubMed  Google Scholar 

  197. Garland SN, Carlson LE, Stephens AJ, Antle MC, Samuels C, Campbell TS. Mindfulness-based stress reduction compared with cognitive behavioral therapy for the treatment of insomnia comorbid with cancer: a randomized, partially blinded, noninferiority trial. J Clin Oncol. 2014;32(5):449–57.

    Article  PubMed  Google Scholar 

  198. Alvarez J, Meyer FL, Granoff DL, Lundy A. The effect of EEG biofeedback on reducing postcancer cognitive impairment. Integr Cancer Ther. 2013;12(6):475–87.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Sleep Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Rachel Paul M.D.

  2. Division of Sleep Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania, TRL, 125 South 31st Street, Suite 2100, Philadelphia, PA, 19104, USA

    Ron C. Anafi M.D., Ph.D.

Authors
  1. Rachel Paul M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ron C. Anafi M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ron C. Anafi M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Sleep Disorders Center, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Hrayr P. Attarian

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Paul, R., Anafi, R.C. (2017). Insomnia in Patients with Comorbid Medical Problems. In: Attarian, H. (eds) Clinical Handbook of Insomnia. Current Clinical Neurology. Springer, Cham. https://doi.org/10.1007/978-3-319-41400-3_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-41400-3_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-41398-3

  • Online ISBN: 978-3-319-41400-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation