Abstract
Early life exposure to air pollution is a pressing public health concern due to well-known respiratory effects and the increasing weight of evidence demonstrating the negative consequences on the developing brain. Air pollution is composed of aerosols and particles produced by vehicle emissions, energy production, and manufacturing and other combustion processes. Fine and ultrafine particles, which contain adsorbed metals and toxic compounds, have the ability to reach the brain to cause damage, as well as generate systemic oxidative stress. Collectively, this chapter highlights current epidemiological and mechanistic studies linking childhood air pollution exposure to adverse neurodevelopmental outcomes, including intellectual, academic, neuropsychological, and behavioral functioning changes. In summary, the accumulating evidence suggests a causative relationship and regulations for prevention should be considered.
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Amato, F., Rivas, I., Viana, M., Moreno, T., Bouso, L., Reche, C., … Querol, X. (2014). Sources of indoor and outdoor PM2. 5 concentrations in primary schools. Science of the Total Environment, 490, 757–765.
Amram, O., Abernethy, R., Brauer, M., Davies, H., & Allen, R. W. (2011). Proximity of public elementary schools to major roads in Canadian urban areas. International Journal of Health Geographics, 10(68), 1–11.
Appatova, A. S., Ryan, P. H., LeMasters, G. K., & Grinshpun, S. A. (2008). Proximal exposure of public schools and students to major roadways: a nationwide US survey. Journal of Environmental Planning and Management, 51(5), 631–646.
Becerra, T. A., Wilhelm, M., Olsen, J., Cockburn, M., & Ritz, B. (2012). Ambient air pollution and autism in Los Angeles County, California. Environmental Health Perspectives, 121(3), 380–386.
Calderón-Garcidueñas, L., Calderón-Garcidueñas, A., Torres-Jardón, R., Avila-RamÃrez, J., Kulesza, R. J., & Angiulli, A. D. (2015). Air pollution and your brain: What do you need to know right now. Primary Health Care Research & Development, 16(4), 329–345.
Calderón-Garcidueñas, L., Cross, J. V., Franco-Lira, M., Aragón-Flores, M., Kavanaugh, M., Torres-Jardón, R., … Zhu, H. (2013). Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution. Frontiers in Neuroscience, 7(183). doi:10.3389/fnins.2013.00183
Calderón-Garcidueñas, L., Engle, R., Mora-Tiscareño, A., Styner, M., Gómez-Garza, G., Zhu, H., … Monroy-Acosta, M. E. (2011). Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children. Brain and Cognition, 77(3), 345–355.
Calderón-Garcidueñas, L., Franco-Lira, M., HenrÃquez-Roldán, C., Osnaya, N., González-Maciel, A., Reynoso-Robles, R., … Keefe, S. (2010). Urban air pollution: influences on olfactory function and pathology in exposed children and young adults. Experimental and Toxicologic Pathology, 62(1), 91–102.
Calderón-Garcidueñas, L., Franco-Lira, M., Mora-Tiscareño, A., Medina-Cortina, H., Torres-Jardón, R., & Kavanaugh, M. (2013). Early Alzheimer’s and Parkinson’s disease pathology in urban children: Friend versus foe responses—It is time to face the evidence. BioMed Research International, 2013, 16. doi:10.1155/2013/161687.
Calderón-Garcidueñas, L., Franco-Lira, M., Torres-Jardón, R., Henriquez-Roldán, C., Barragán-MejÃa, G., Valencia-Salazar, G., … Reed, W. (2007). Pediatric respiratory and systemic effects of chronic air pollution exposure: Nose, lung, heart, and brain pathology. Toxicologic pathology, 35(1), 154–162.
Calderón-Garcidueñas, L., Kavanaugh, M., Block, M., D'Angiulli, A., Delgado-Chávez, R., Torres-Jardón, R., … Villarreal-Calderon, R. (2012). Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults. Journal of Alzheimer's Disease, 28(1), 93–107.
Calderón-Garcidueñas, L., MacÃas-Parra, M., Hoffmann, H. J., Valencia-Salazar, G., HenrÃquez-Roldán, C., Osnaya, N., … Romero, L. (2009). Immunotoxicity and environment: Immunodysregulation and systemic inflammation in children. Toxicologic Pathology, 37(2), 161–169.
Calderón-Garcidueñas, L., Mora-Tiscareño, A., Ontiveros, E., Gómez-Garza, G., Barragán-MejÃa, G., Broadway, J., … Maronpot, R. R. (2008). Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs. Brain and Cognition, 68(2), 117–127.
Calderón-Garcidueñas, L., Solt, A. C., HenrÃquez-Roldán, C., Torres-Jardón, R., Nuse, B., Herritt, L., … GarcÃa, R. (2008). Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid β-42 and α-synuclein in children and young adults. Toxicologic Pathology, 36(2), 289–310.
Calderon-Garciduenas, L., & Torres-Jardon, R. (2012). Air pollution, socioeconomic status, and children's cognition in megacities: The Mexico City scenario. Frontiers in Psychology, 3, 217. doi:10.3389/fpsyg.2012.00217.
Centers for Disease Control and Prevention (CDC). (2015a). Attention-deficit/hyperactivity disorder (ADHD). Retrieved February 20, 2015, from http://www.cdc.gov/ncbddd/adhd/index.html
Centers for Disease Control and Prevention (CDC). (2015b). Autism spectrum disorder (ASD). Retrieved February 20, 2015, from http://www.cdc.gov/ncbddd/autism/index.html
Chiu, Y.-H. M., Bellinger, D. C., Coull, B. A., Anderson, S., Barber, R., Wright, R. O., & Wright, R. J. (2013). Associations between traffic-related black carbon exposure and attention in a prospective birth cohort of urban children. Environmental Health Perspectives, 121(7), 859–864.
Currie, J., Hanushek, E. A., Kahn, E. M., Neidell, M., & Rivkin, S. G. (2009). Does pollution increase school absences? The Review of Economics and Statistics, 91(4), 682–694.
Diapouli, E., Chaloulakou, A., & Spyrellis, N. (2007). Levels of ultrafine particles in different microenvironments—Implications to children exposure. Science of the Total Environment, 388(1), 128–136.
Donaldson, K., Tran, L., Jimenez, L. A., Duffin, R., Newby, D. E., Mills, N., … Stone, V. (2005). Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Particle and Fibre Toxicology, 2(1), 10. doi:0.1186/1743-8977-2-10
Edwards, S. C., Jedrychowski, W., Butscher, M., Camann, D., Kieltyka, A., Mroz, E., … Perera, F. (2010). Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland. Environmental Health Perspectives, 118(9), 1326–1331. doi:10.1289/ehp.0901070
Elder, A., Gelein, R., Silva, V., Feikert, T., Opanashuk, L., Carter, J., … Finkelstein, J. (2006). Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environmental Health Perspectives, 114, 172–1178.
EPA, U. S. E. P. A. (2011, March 22). National ambient air quality standards. Retrieved September 21, 2011, from http://www.epa.gov/ttn/naaqs
Freire, C., Ramos, R., Puertas, R., Lopez-Espinosa, M. J., Julvez, J., Aguilera, I., … Olea, N. (2010). Association of traffic-related air pollution with cognitive development in children. Journal of Epidemiology and Community Health, 64(3), 223–228. doi:10.1136/jech.2008.084574.
Gilliland, F. D., Berhane, K., Rappaport, E. B., Thomas, D. C., Avol, E., Gauderman, W. J., … Islam, K. T. (2001). The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology, 12(1), 43–54.
Guo, H., Morawska, L., He, C., Zhang, Y. L., Ayoko, G., & Cao, M. (2010). Characterization of particle number concentrations and PM2. 5 in a school: influence of outdoor air pollution on indoor air. Environmental Science and Pollution Research, 17(6), 1268–1278.
Guxens, M., Aguilera, I., Ballester, F., Estarlich, M., Fernandez-Somoano, A., Lertxundi, A., … Project, I. (2012). Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors. Environmental Health Perspectives, 120(1), 144–149. doi:10.1289/ehp.1103469
Herbert, M. R. (2010). Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Current Opinion in Neurology, 23(2), 103–110.
Janssen, N. A., van Vliet, P. H., Aarts, F., Harssema, H., & Brunekreef, B. (2001). Assessment of exposure to traffic related air pollution of children attending schools near motorways. Atmospheric Environment, 35(22), 3875–3884.
Jedrychowski, W., Flak, E., Mroz, E., Pac, A., Jacek, R., Sochacka-Tatara, E., … Perera, F. (2008). Modulating effects of maternal fish consumption on the occurrence of respiratory symptoms in early infancy attributed to prenatal exposure to fine particles. Annals of Nutrition & Metabolism, 52(1), 8–16.
Jedrychowski, W., Perera, F., Mrozek-Budzyn, D., Flak, E., Mroz, E., Sochacka-Tatara, E., … Spengler, J. D. (2010). Higher fish consumption in pregnancy may confer protection against the harmful effect of prenatal exposure to fine particulate matter. Annals of Nutrition & Metabolism, 56(2), 119.
Kim, K.-H., Jahan, S. A., Kabir, E., & Brown, R. J. (2013). A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. Environment International, 60, 71–80.
Kim, E., Park, H., Hong, Y.-C., Ha, M., Kim, Y., Kim, B.-N., … Ryu, J.-M. (2014). Prenatal exposure to PM 10 and NO 2 and children’s neurodevelopment from birth to 24 months of age: Mothers and Children's Environmental Health (MOCEH) study. Science of the Total Environment, 481, 439–445.
Kueny, A., Berg, J., Chowdhury, Y., & Anderson, N. (2011). Poquito a poquito: How Latino families with children who have asthma make changes in their home. Journal of Pediatric Health Care, 27(1), e1–e11.
Larsson, M., Weiss, B., Janson, S., Sundell, J., & Bornehag, C.-G. (2009). Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6–8 years of age. Neurotoxicology, 30(5), 822–831.
Lee, S. S., Humphreys, K. L., Flory, K., Liu, R., & Glass, K. (2011). Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: A meta-analytic review. Clinical Psychology Review, 31(3), 328–341.
Miller S, Vela M (2013) The effects of air pollution on educational outcomes: Evidence from Chile IDB Working Paper No. IDB-WP-468. Washington, DC: Inter-American Development Bank, Research Department.
Mohai, P., Kweon, B. S., Lee, S., & Ard, K. (2011). Air pollution around schools is linked to poorer student health and academic performance. Health Affairs (Project Hope), 30(5), 852–862. doi:10.1377/hlthaff.2011.0077.
Mohai, P., Pellow, D., & Roberts, J. T. (2009). Environmental justice. Annual Review of Environment and Resources, 34, 405–430.
Morales, E., Julvez, J., Torrent, M., de Cid, R., Guxens, M., Bustamante, M., … Sunyer, J. (2009). Association of early-life exposure to household gas appliances and indoor nitrogen dioxide with cognition and attention behavior in preschoolers. American Journal of Epidemiology, 169(11), 1327–1336. doi:10.1093/aje/kwp067.
Nemmar, A., Vanbilloen, H., Hoylaerts, M., Hoet, P., Verbruggen, A., & Nemery, B. (2001). Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. American Journal of Respiratory and Critical Care Medicine, 164(9), 1665–1668.
Newman, N. C., Ryan, P., LeMasters, G., Levin, L., Bernstein, D., Hershey, G. K., … Grinshpun, S. (2013). Traffic-related air pollution exposure in the first year of life and behavioral scores at 7 years of age. Environmental Health Perspectives, 121(6), 731–736.
Pastor, M., Sadd, J. L., & Morello-Frosch, R. (2004). Reading, writing, and toxics: children's health, academic performance, and environmental justice in Los Angeles. Environment and Planning C, 22(2), 271–290.
Perera, F. P., Chang, H.-w., Tang, D., Roen, E. L., Herbstman, J., Margolis, A., … Rauh, V. (2014). Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One, 9(11). doi:10.1371/journal.pone.0111670.
Perera, F. P., Li, Z., Whyatt, R., Hoepner, L., Wang, S., Camann, D., & Rauh, V. (2009). Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics, 124(2), e195–e202. doi:10.1542/peds.2008-3506.
Perera, F. P., Li, T. Y., Zhou, Z. J., Yuan, T., Chen, Y. H., Qu, L., … Tang, D. (2008). Benefits of reducing prenatal exposure to coal-burning pollutants to children’s neurodevelopment in China. Environmental Health Perspectives, 116(10), 1396–1400.
Perera, F. P., Rauh, V., Whyatt, R. M., Tsai, W.-Y., Tang, D., Diaz, D., … Camann, D. (2006). Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives, 114, 1287–1292.
Perera, F. P., Tang, D., Wang, S., Vishnevetsky, J., Zhang, B., Diaz, D., … Rauh, V. (2012). Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6–7 years. Environmental Health Perspectives, 120(6), 921–926.
Pope, C. A., & Dockery, D. W. (2006). Health effects of fine particulate air pollution: Lines that connect. Journal of the Air & Waste Management Association, 56(6), 709–742.
Roberts, A. L., Lyall, K., Hart, J. E., Laden, F., Just, A. C., Bobb, J. F., … Weisskopf, M. G. (2013). Perinatal air pollutant exposures and autism spectrum disorder in the children of Nurses’ Health Study II participants. Environmental Health Perspectives, 121(8), 978–984.
Romieu, I., Castro-Giner, F., Kunzli, N., & Sunyer, J. (2008). Air pollution, oxidative stress and dietary supplementation: A review. European Respiratory Journal, 31(1), 179–197.
Shaw, M., Hodgkins, P., Caci, H., Young, S., Kahle, J., Woods, A. G., & Arnold, L. E. (2012). A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: Effects of treatment and non-treatment. BMC Medicine, 10, 99-7015-7010-7099. doi:10.1186/1741-7015-10-99.
Siddique, S., Banerjee, M., Ray, M. R., & Lahiri, T. (2011). Attention-deficit hyperactivity disorder in children chronically exposed to high level of vehicular pollution. European Journal of Pediatrics, 170(7), 923–929.
Suglia, S. F., Gryparis, A., Wright, R. O., Schwartz, J., & Wright, R. J. (2008). Association of black carbon with cognition among children in a prospective birth cohort study. American Journal of Epidemiology, 167(3), 280–286. doi:10.1093/aje/kwm308.
Suwanwaiphatthana, W., Ruangdej, K., & Turner-Henson, A. (2010). Outdoor air pollution and children's health. Pediatric Nursing, 36(1), 25–32.
Szyszkowicz, M., Willey, J. B., Grafstein, E., Rowe, B. H., & Colman, I. (2010). Air pollution and emergency department visits for suicide attempts in Vancouver, Canada. Environmental Health Insights, 4, 79–86. doi:10.4137/EHI.S5662.
Tang, D., Li, T. Y., Liu, J. J., Zhou, Z. J., Yuan, T., & Chen, Y. H. (2008). Effects of prenatal exposure to coal-burning pollutants on children’s development in China. Environmental Health Perspectives, 116(5), 674–679.
Tin-Tin-Win-Shwe, Yamamoto, S., Ahmed, S., Kakeyama, M., Kobayashi, T., & Fujimaki, H. (2006). Brain cytokine and chemokine mRNA expression in mice induced by intranasal instillation with ultrafine carbon black. Toxicology Letters, 163(2), 153–160.
Van Roosbroeck, S., Jacobs, J., Janssen, N. A., Oldenwening, M., Hoek, G., & Brunekreef, B. (2007). Long-term personal exposure to PM 2.5, soot and NOx in children attending schools located near busy roads, a validation study. Atmospheric Environment, 41(16), 3381–3394.
Villarreal-Calderon, R., Torres-Jardon, R., Palacios-Moreno, J., Osnaya, N., Perez-Guille, B., Maronpot, R. R., … Calderon-Garciduenas, L. (2010). Urban air pollution targets the dorsal vagal complex and dark chocolate offers neuroprotection. International Journal of Toxicology, 29(6), 604–615.
Volk, H. E., Hertz-Picciotto, I., Delwiche, L., Lurmann, F., & McConnell, R. (2011). Residential proximity to freeways and autism in the CHARGE study. Environmental Health Perspectives, 119(6), 873–877.
Volk, H. E., Kerin, T., Lurmann, F., Hertz-Picciotto, I., McConnell, R., & Campbell, D. B. (2014). Autism spectrum disorder: Interaction of air pollution with the MET receptor tyrosine kinase gene. Epidemiology (Cambridge, MA), 25(1), 44–47.
Volk, H. E., Lurmann, F., Penfold, B., Hertz-Picciotto, I., & McConnell, R. (2013). Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry, 70(1), 71–77.
Vrijheid, M., Martinez, D., Aguilera, I., Bustamante, M., Ballester, F., Estarlich, M., … Project, I. (2012). Indoor air pollution from gas cooking and infant neurodevelopment. Epidemiology (Cambridge, MA), 23(1), 23–32. doi:10.1097/EDE.0b013e31823a4023.
Wang, S., Zhang, J., Zeng, X., Zeng, Y., & She, W. (2009). Association of traffic-related air pollution with children’s neurobehavioral functions in Quanzhou, China. Environmental Health Perspectives, 117, 1612–1618.
Windham, G. C., Zhang, L., Gunier, R., Croen, L. A., & Grether, J. K. (2006). Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area. Environmental Health Perspectives, 114, 1438–1444.
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Johnson, N.M., Carrillo, G., Mehta, R.K. (2016). Academic and Psychosocial Impact of Air Pollution on Children. In: Riccio, C., Sullivan, J. (eds) Pediatric Neurotoxicology. Specialty Topics in Pediatric Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-32358-9_9
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