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Calixsugars: Finally Reaching Their Therapeutic Potential?

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Abstract

The synthesis and properties of members of the calixarene family functionalised with carbohydrates have been extensively investigated for the past 20 years. These calixsugars show great potential for applications in the fields of medicinal chemistry, drug and gene delivery, through their ability to bind to lectins and to inhibit enzymes. In this chapter, the current therapeutic status of calixsugars for a range of diseases is discussed, including in vivo evaluation. Applications in bacterial infections and cancer are covered, in addition to recent developments in their use as carrier molecules and vectors in gene therapy.

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  1. School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK

    Susan E. Matthews

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  1. Dipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, Fisciano, Salerno, Italy

    Placido Neri

  2. Department of Chemistry, The University of Texas, Austin, Texas, USA

    Jonathan L. Sessler

  3. Department of Chemistry, Tsinghua University, Beijing, China

    Mei-Xiang Wang

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Matthews, S.E. (2016). Calixsugars: Finally Reaching Their Therapeutic Potential?. In: Neri, P., Sessler, J., Wang, MX. (eds) Calixarenes and Beyond. Springer, Cham. https://doi.org/10.1007/978-3-319-31867-7_22

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