Abstract
In this paper we describe the Myocardial Uncertainty Viewer (muView or μView) system for exploring data stemming from the simulation of cardiac ischemia. The simulation uses a collection of conductivity values to understand how ischemic regions effect the undamaged anisotropic heart tissue. The data resulting from the simulation is multi-valued and volumetric, and thus, for every data point, we have a collection of samples describing cardiac electrical properties. μView combines a suite of visual analysis methods to explore the area surrounding the ischemic zone and identify how perturbations of variables change the propagation of their effects. In addition to presenting a collection of visualization techniques, which individually highlight different aspects of the data, the coordinated view system forms a cohesive environment for exploring the simulations. We also discuss the findings of our study, which are helping to steer further development of the simulation and strengthening our collaboration with the biomedical engineers attempting to understand the phenomenon.
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References
Berger, W., Piringer, H., Filzmoser, P., Gröller, E.: Uncertainty-aware exploration of continuous parameter spaces using multivariate prediction. Comput. Graph. Forum 30(3), 911–920 (2011)
Bordoloi, U.D., Kao, D.L., Shen, H.W.: Visualization techniques for spatial probability density function data. Data Sci. J. 3, 153–162 (2004)
Clerc, L.: Directional differences of impulse spread in trabecular muscle from mammalian heart. J. Physiol. 255, 335–346 (1976)
Djurcilov, S., Kim, K., Lermusiaux, P., Pang, A.: Visualizing scalar volumetric data with uncertainty. Comput. Graph. 26, 239–248 (2002)
Feng, D., Kwock, L., Lee, Y., Taylor II, R.M.: Linked exploratory visualizations for uncertain mr spectroscopy data. SPIE Vis. Data Anal. 7530(4), 1–12 (2010)
Feng, D., Kwock, L., Lee, Y., Taylor II, R.M.: Matching visual saliency to confidence in plots of uncertain data. IEEE Trans. Vis. Comput. Graph. 16(6), 980–989 (2010)
Fleischmann, K.E., Zègre-Hemsey, J., Drew, B.J.: The new universal definition of myocardial infarction criteria improves electrocardiographic diagnosis of acute coronary syndrome. J. Electrocardiol. 44, 69–73 (2011)
Fout, N., Ma, K.L.: Fuzzy volume rendering. IEEE Trans. Vis. Comput. Graph. 18(12), 2335–2344 (2012)
Geneser, S., Hinkle, J., Kirby, R., Wang, B., Salter, B., Joshi, S.: Quantifying variability in radiation dose due to respiratory-induced tumor motion. Med. Image Anal. 15(4), 640–649 (2011)
Griethe, H., Schumann, H.: Visualization of uncertain data: methods and problems. In: Proceedings of Simulation and Visualization, pp. 143–156 (2006)
Haroz, S., Ma, K.L., Heitmann, K.: Multiple uncertainties in time-variant cosmological particle data. In: IEEE Pacific Visualization, pp. 207–214 (2008)
Henriquez, C.: Simulating the electrical behaviour of cardiac tissue using the bidomain model. Crit. Rev. Biomed. Eng. 21(1), 1–77 (1993)
Hopenfeld, B., Stinstra, J., Macleod, R.: Mechanism for st depression associated with contiguous subendocardial ischemia. J. Cardiovasc. Electrophysiol. 15(10), 1200–1206 (2004)
Jiao, F., Phillips, J., Gur, Y., Johnson, C.: Uncertainty visualization in HARDI based on ensembles of ODFs. In: IEEE Pacific Visualization, pp. 193–200 (2012)
Johnson, C.: Numerical methods for bioelectric field problems. In: Bronzino, J. (ed.) The Biomedical Engineering Handbook, pp. 161–188. CRC, Boca Ratan (1995)
Johnson, C.R.: Top scientific visualization research problems. IEEE Comput. Graph. Appl. Mag. 24(4), 13–17 (2004)
Johnson, C., Sanderson, A.: Next step: visualizing errors and uncertainty. IEEE Comput. Graph. Appl. Mag. 23(5), 6–10 (2003)
Johnson, C., MacLeod, R., Matheson, M.: Computer simulations reveal complexity of electrical activity in the human thorax. Comput. Phys. 6, 230–237 (1992)
Johnson, C., MacLeod, R., Matheson, M.: Computational medicine: bioelectric field problems. IEEE Comput. 26(26), 59–67 (1993)
Johnston, P.R.: A cylindrical model for studying subendocardial ischaemia in the left ventricle. Math. Biosci. 186, 43–61 (2003)
Johnston, P.R., Kilpatrick, D.: The effect of conductivity values on st segment shift in subendocardial ischaemia. IEEE Trans. Biomed. Eng. 50, 150–158 (2003)
Jones, D.K.: Determining and visualizing uncertainty in estimates of fiber orientation from diffusion tensor MRI. Magn. Reson. Med. 49, 7–12 (2003)
Jospeh, A.J., Lodha, S.K., Renteria, J.C., Pang, A.: Uisurf: Visualizing uncertainty in isosurfaces. In: Computer Graphics and Imaging, pp. 184–191 (1999)
Kao, D., Dungan, J.L., Pang, A.: Visualizing 2d probability distributions from eos satellite image-derived data sets: a case study. In: IEEE Visualization Conference, pp. 457–561 (2001)
Kao, D., Luo, A., Dungan, J.L., Pang, A.: Visualizing spatially varying distribution data. In: Information Visualisation, pp. 219–225 (2002)
Kao, D., Kramer, M., Luo, A., Dungan, J., Pang, A.: Visualizing distributions from multi-return lidar data to understand forest structure. Cartogr. J. 42(1), 35–47 (2005)
Kruskal, J., Wish, M.: Multidimensional scaling. Sage University Paper series on Quantitative Application in the Social Sciences, vol. 07-011. Sage Publication, Beverly Hills/London (1978)
Lawonn, K., Moench, T., Preim, B.: Streamlines for illustrative real-time rendering. Comput. Graph. Forum 32(3), 321–330 (2013)
Lucieer, A.: Visualization for exploration of uncertainty related to fuzzy classification. In: IEEE International Conference on Geoscience and Remote Sensing, pp. 903–906 (2006)
Lundström, C., Ljung, P., Persson, A., Ynnerman, A.: Uncertainty visualization in medical volume rendering using probabilistic animation. IEEE Trans. Vis. Comput. Graph. 13(6), 1648–1655 (2007)
Luo, A., Kao, D., Pang, A.: Visualizing spatial distribution data sets. In: Symposium on Data Visualization, pp. 29–38 (2003)
MacEachren, A.M., Robinson, A., Hopper, S., Gardner, S., Murray, R., Gahegan, M., Hetzler, E.: Visualizing geospatial information uncertainty: what we know and what we need to know. Cartogr. Geogr. Inf. Sci. 32(3), 139–160 (2005)
MacQueen, J., et al.: Some methods for classification and analysis of multivariate observations. In: Berkeley Symposium on Mathematical Statistics and Probability, vol. 1, p. 14 (1967)
Mathers, C.D., Fat, D.M., Boerma, J.T.: The global burden of disease: 2004 update. Technical Report, World Health Organization (2004)
Pang, A., Wittenbrink, C., Lodha., S.: Approaches to uncertainty visualization. Vis. Comput. 13(8), 370–390 (1997)
Pearson, K.: On lines and planes of closest fit to systems of points in space. Philos. Mag. 2(6), 559–572 (1901)
Pfaffelmoser, T., Reitinger, M., Westermann, R.: Visualizing the positional and geometrical variability of isosurfaces in uncertain scalar fields. Comput. Graph. Forum 30(3), 951–960 (2011)
Pfaffelmoser, T., Mihai, M., Westermann, R.: Visualizing the variability of gradients in uncertain 2d scalar fields. IEEE Trans. Vis. Comput. Graph. 19(11), 1948–1961 (2013)
Pöthkow, K., Heg, H.C.: Positional uncertainty of isocontours: condition analysis and probabilistic measures. IEEE Trans. Vis. Comput. Graph. PP(99), 1–15 (2010)
Pöthkow, K., Weber, B., Hege, H.C.: Probabilistic marching cubes. Comput. Graph. Forum 30(3), 931–940 (2011)
Potter, K., Wilson, A., Bremer, P.T., Williams, D., Doutriaux, C., Pascucci, V., Johhson, C.R.: Ensemble-vis: a framework for the statistical visualization of ensemble data. In: IEEE Workshop on Knowledge Discovery from Climate Data: Prediction, Extremes, pp. 233–240 (2009)
Potter, K., Kniss, J., Riesenfeld, R., Johnson, C.: Visualizing summary statistics and uncertainty. In: Computer Graphics Forum (Proceedings of Eurovis 2010), vol. 29, pp. 823–831 (2010)
Potter, K., Kirby, R., Xiu, D., Johnson, C.: Interactive visualization of probability and cumulative density functions. Int. J. Uncertain. Quantif. 2(4), 397–412 (2012)
Rhodes, P.J., Laramee, R.S., Bergeron, R.D., Sparr, T.M.: Uncertainty visualization methods in isosurface rendering. In: Eurographics Short Papers, pp. 83–88 (2003)
Roberts, D.E., Scher, A.M.: Effects of tissue anisotropy on extracellular potential fields in canine myocardium in situ. Circ. Res. 50, 342–351 (1982)
Roberts, D.E., Hersh, L.T., Scher, A.M.: Influence of cardiac fiber orientation on wavefront voltage, conduction velocity and tissue resistivity in the dog. Circ. Res. 44, 701–712 (1979)
Rodgers, J.L., Nicewander, W.A.: Thirteen ways to look at the correlation coefficient. Am. Stat. 42(1), 59–66 (1988)
Roweis, S.T., Saul, L.K.: Nonlinear dimensionality reduction by locally linear embedding. Science 290(5500), 2323–2326 (2000)
Sanyal, J., Zhang, S., Dyer, J., Mercer, A., Amburn, P., Moorhead, R.J.: Noodles: a tool for visualization of numerical weather model ensemble uncertainty. IEEE Trans. Vis. Comput. Graph. 16(6), 1421–1430 (2010)
Smolyak, S.: Quadrature and interpolation formulas for tensor products of certain classes of functions. Sov. Math. Dokl. 4, 240–243 (1963)
Sugar, C.A., Gareth, James, M.: Finding the number of clusters in a data set: An information theoretic approach. J. Am. Stat. Assoc. 98, 750–763 (2003)
Toyoshima, H., Ekmekci, A., Flamm, E., Mizuno, Y., Nagaya, T., Nakayama, R., Yamada, K., Prinzmetal, M.: Angina pectoris vii. The nature of st depression in acute myocardial ischaemia. Am. J. Cardiol. 13, 498–509 (1964)
Whitaker, R.T., Mirzargar, M., Kirby, R.M.: Contour boxplots: a method for characterizing uncertainty in feature sets from simulation ensembles. IEEE Trans. Vis. Comput. Graph. 19(12), 2713–2722 (2013)
Xiu, D.: Efficient collocational approach for parametric uncertainty analysis. Commun. Comput. Phys. 2, 293–309 (2007)
Acknowledgements
This project was supported by grants from the National Center for Research Resources (5P41RR012553-14), National Institutes of Health’s National Institute of General Medical Sciences (8 P41 GM103545-14), DOE NETL, and King Abdullah University of Science and Technology (KUS-C1-016-04).
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Rosen, P., Burton, B., Potter, K., Johnson, C.R. (2016). muView: A Visual Analysis System for Exploring Uncertainty in Myocardial Ischemia Simulations. In: Linsen, L., Hamann, B., Hege, HC. (eds) Visualization in Medicine and Life Sciences III. Mathematics and Visualization. Springer, Cham. https://doi.org/10.1007/978-3-319-24523-2_3
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DOI: https://doi.org/10.1007/978-3-319-24523-2_3
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