Skip to main content

Hip Sepsis and the Prevention of Perioperative Infections

  • Chapter

Abstract

Total hip arthroplasty (THA) is a very successful surgical procedure; however, periprosthetic joint infection (PJI) is a devastating complication after total joint arthroplasty (TJA). The incidence of deep infection has declined, but the total number of infections is increasing because of significant increases in the number of hip and knee surgeries performed each year.

Recent improvements in perioperative techniques have enabled operation on patients with higher infection risk factors and comorbidities; however, the emergence of resistant bacterial strains represents a challenge in preventing deep infection.

Infection risk can be reduced by optimizing modifiable factors related to the preoperative, surgical, and postoperative periods including patient-related and environmental factors and surgical technique. Malnourished or anemic patients, those with chronic diseases, or those with tobacco and alcohol abuse represent special risk groups. The principles of infection prevention in these patients are well-documented, but adherence to surgical and postoperative care protocols should be improved. In order to control PJI, identification of modifiable risk factors must be the first, essential part of current infection prevention practices.

This chapter identifies common, modifiable risk factors and defines strategies for optimizing and caring for patients pre-, peri-, and post-operatively that may help to further reduce deep infection rates.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

AAOS:

American Academy of Orthopaedic Surgeons

CHG:

Chlorhexidine gluconate

CRF:

Chronic renal failure

DM:

Diabetes mellitus

DMARDs:

Disease-modifying anti-rheumatic drugs

IJD:

Inflammatory joint disease

INR:

International normalized ratio

MIC:

Minimal Inhibitory Concentrations

MRSA:

Methicillin resistant staphylococcus aureus

MSIS:

The Musculoskeletal Infection Society

OR:

Operating room

PJI:

Periprosthetic joint infection

RA:

Rheumatoid Arthritis

SSI:

Surgical site infection

THA:

Total hip arthroplasty

TJA:

Total joint arthroplasty

References

  1. Parvizi J, Gehrke T. Definition of periprosthetic joint infection. J Arthroplasty. 2014;29:1331.

    PubMed  Google Scholar 

  2. Bartzokas CA, Johnson R, Jane M, Martin MV, Pearce PK, Saw Y. Relation between mouth and haematogenous infection in total joint replacements. Br Med J. 1994;309:506–8.

    CAS  Google Scholar 

  3. Lalani T, Chu VH, Grussemeyer CA, et al. Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections. Scand J Infect Dis. 2008;40:973–7.

    PubMed  Google Scholar 

  4. Young H, Hirsh J, Hammerberg EM, Price CS. Dental disease and periprosthetic joint infection. J Bone Joint Surg Am. 2014;96:162–8.

    PubMed  Google Scholar 

  5. Barrington JW, Barrington TA. What is the true incidence of dental pathology in the total joint arthroplasty population? J Arthroplasty. 2011;26:88–91.

    PubMed  Google Scholar 

  6. Della Valle C, Parvizi J, Bauer TW, et al. American Academy of Orthopaedic Surgeons clinical practice guideline on: the diagnosis of periprosthetic joint infections of the hip and knee. J Bone Joint Surg Am. 2011;93:1355–7.

    PubMed  Google Scholar 

  7. Tokarski AT, Patel RG, Parvizi J, Deirmengian GK. Dental clearance prior to elective arthroplasty may not be needed for everyone. J Arthroplasty. 2014. doi:10.1016/j.arth.2014.04.018.

    Google Scholar 

  8. Kalmeijer MD, van Nieuwland-Bollen E, Bogaers-Hofman D, de Baere GA. Nasal carriage of Staphylococcus aureus is a major risk factor for surgical-site infections in orthopedic surgery. Infect Control Hosp Epidemiol. 2000;21:319–23.

    CAS  PubMed  Google Scholar 

  9. Herwaldt LA, Cullen JJ, French P, Hu J, Pfaller MA, Wenzel RP, Perl TM. Preoperative risk factors for nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol. 2004;25:481–4.

    PubMed  Google Scholar 

  10. Williams R. Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriol Rev. 1963;27:56–71.

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Verhoeven PO, Gagnaire J, Botelho-Nevers E, Grattard F, Carricajo A, Lucht F, Pozzetto B, Berthelot P. Detection and clinical relevance of Staphylococcus aureus nasal carriage: an update. Expert Rev Anti Infect Ther. 2014;12:75–89.

    CAS  PubMed  Google Scholar 

  12. Chen AF, Heyl AE, Xu PZ, Rao N, Klatt BA. Preoperative decolonization effective at reducing staphylococcal colonization in total joint arthroplasty patients. J Arthroplasty. 2013;28:18–20.

    PubMed  Google Scholar 

  13. Ridenour G, Lampen R, Federspiel J, Kritchevsky S, Wong E, Climo M. Selective use of intranasal mupirocin and chlorhexidine bathing and the incidence of methicillin-resistant Staphylococcus aureus colonization and infection among intensive care unit patients. Infect Control Hosp Epidemiol. 2007;28:1155–61.

    PubMed  Google Scholar 

  14. Economedes DM, Deirmengian GK, Deirmengian CA. Staphylococcus aureus colonization among arthroplasty patients previously treated by a decolonization protocol: a pilot study. Clin Orthop Relat Res. 2013;471:3128–32.

    PubMed Central  PubMed  Google Scholar 

  15. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Roderick Davey J, Gandhi R, Syed KA, Muhammad Ovais Hasan S, De Silva Y, Chung F. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am. 2010;92:2503–13.

    PubMed  Google Scholar 

  16. Møller AM, Villebro N, Pedersen T, Tønnesen H. Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial. Lancet. 2002;359:114–7.

    PubMed  Google Scholar 

  17. Singh JA. Smoking and outcomes after knee and hip arthroplasty: a systematic review.J Rheumatol. 2011;38:1824–34.

    PubMed Central  PubMed  Google Scholar 

  18. Mills E, Eyawo O, Lockhart I, Kelly S, Wu P, Ebbert JO. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124:144–54. e8.

    PubMed  Google Scholar 

  19. Sadr Azodi O, Bellocco R, Eriksson K, Adami J. The impact of tobacco use and body mass index on the length of stay in hospital and the risk of post-operative complications among patients undergoing total hip replacement. J Bone Joint Surg Br. 2006;88:1316–20.

    CAS  PubMed  Google Scholar 

  20. Everhart JS, Altneu E, Calhoun JH. Medical comorbidities are independent preoperative risk factors for surgical infection after total joint arthroplasty. Clin Orthop Relat Res. 2013;471:3112–9.

    PubMed Central  PubMed  Google Scholar 

  21. Alijanipour P, Heller S, Parvizi J. Prevention of periprosthetic joint infection: what are the effective strategies? J Knee Surg. 2014;27:251–8.

    PubMed  Google Scholar 

  22. Bradley KA, Williams EC, Achtmeyer CE, Hawkins EJ, Harris AHS, Frey MS, Craig T, Kivlahan DR. Measuring performance of brief alcohol counseling in medical settings: a review of the options and lessons from the Veterans Affairs (VA) health care system. Subst Abus. 2007;28:133–49.

    PubMed  Google Scholar 

  23. Litaker D, Locala J, Franco K, Bronson DL, Tannous Z. Preoperative risk factors for postoperative delirium. Gen Hosp Psychiatry. 2001;23:84–9.

    CAS  PubMed  Google Scholar 

  24. Tonnesen H, Rosenberg J, Nielsen HJ, Rasmussen V, Hauge C, Pedersen IK, Kehlet H. Effect of preoperative abstinence on poor postoperative outcome in alcohol misusers: randomised controlled trial. BMJ. 1999;318:1311–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  25. Aggarwal VK, Tischler EH, Lautenbach C, et al. Mitigation and education. J Orthop Res. 2014;32 Suppl 1:S16–25.

    PubMed  Google Scholar 

  26. Marchant MH, Viens NA, Cook C, Vail TP, Bolognesi MP. The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty. J Bone Joint Surg Am. 2009;91:1621–9.

    PubMed  Google Scholar 

  27. Dronge AS, Perkal MF, Kancir S, Concato J, Aslan M, Rosenthal RA. Long-term glycemic control and postoperative infectious complications. Arch Surg. 2006;141:375–80. discussion 380.

    PubMed  Google Scholar 

  28. Viens NA, Hug KT, Marchant MH, Cook C, Vail TP, Bolognesi MP. Role of diabetes type in perioperative outcomes after hip and knee arthroplasty in the United States. J Surg Orthop Adv. 2012;21:253–60.

    PubMed  Google Scholar 

  29. Kiran RP, Turina M, Hammel J, Fazio V. The clinical significance of an elevated postoperative glucose value in nondiabetic patients after colorectal surgery: evidence for the need for tight glucose control? Ann Surg. 2013;258:599–604. discussion 604–5.

    PubMed  Google Scholar 

  30. Kotagal M, Symons RG, Hirsch IB, Umpierrez GE, Dellinger EP, Farrokhi ET, Flum DR. Perioperative hyperglycemia and risk of adverse events among patients with and without diabetes. Ann Surg. 2014;00:1–7.

    Google Scholar 

  31. Mraovic B, Suh D, Jacovides C, Parvizi J. Perioperative hyperglycemia and postoperative infection after lower limb arthroplasty. J Diabetes Sci Technol. 2011;5:412–8.

    PubMed Central  PubMed  Google Scholar 

  32. Kwon S, Thompson R, Dellinger P, Yanez D, Farrohki E, Flum D. Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program. Ann Surg. 2013;257:8–14.

    PubMed Central  PubMed  Google Scholar 

  33. Frisch A, Chandra P, Smiley D, et al. Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery. Diabetes Care. 2010;33:1783–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  34. Ziser A, Plevak DJ, Wiesner RH, Rakela J, Offord KP, Brown DL. Morbidity and mortality in cirrhotic patients undergoing anesthesia and surgery. Anesthesiology. 1999;90:42–53.

    CAS  PubMed  Google Scholar 

  35. Bolognesi M, Merkel C, Bianco S, Angeli P, Sacerdoti D, Amodio P, Gatta A. Clinical significance of the evaluation of hepatic reticuloendothelial removal capacity in patients with cirrhosis. Hepatology. 1994;19:628–34.

    CAS  PubMed  Google Scholar 

  36. Fiuza C, Salcedo M, Clemente G, Tellado JM. In vivo neutrophil dysfunction in cirrhotic patients with advanced liver disease. J Infect Dis. 2000;182:526–33.

    CAS  PubMed  Google Scholar 

  37. Hsieh P-H, Ueng SW, Lee MS, Shih H-N, Huang K-C. Prosthetic hip infection in patients with liver cirrhosis: an outcome analysis. Int J Infect Dis. 2010;14:e1054–9.

    PubMed  Google Scholar 

  38. Rice HE, O’Keefe GE, Helton WS, Johansen K. Morbid prognostic features in patients with chronic liver failure undergoing nonhepatic surgery. Arch Surg. 1997;132:880–5.

    CAS  PubMed  Google Scholar 

  39. Cohen SM, Te HS, Levitsky J. Operative risk of total hip and knee arthroplasty in cirrhotic patients. J Arthroplasty. 2005;20:460–6.

    PubMed  Google Scholar 

  40. Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, Lin JK. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. 1997;15:1867–76.

    CAS  PubMed  Google Scholar 

  41. Garrison RN, Cryer HM, Howard DA, Polk HC. Clarification of risk factors for abdominal operations in patients with hepatic cirrhosis. Ann Surg. 1984;199:648–55.

    CAS  PubMed Central  PubMed  Google Scholar 

  42. Moon Y-W, Kim Y-S, Kwon S-Y, Kim S-Y, Lim S-J, Park Y-S. Perioperative risk of hip arthroplasty in patients with cirrhotic liver disease. J Korean Med Sci. 2007;22:223–6.

    PubMed Central  PubMed  Google Scholar 

  43. Li W-C, Shih C-H, Ueng SW, Shih H-N, Lee MS, Hsieh P-H. Uncemented total hip arthroplasty in chronic hemodialysis patients. Acta Orthop. 2010;81:178–82.

    PubMed Central  PubMed  Google Scholar 

  44. Nagoya S, Nagao M, Takada J, Kuwabara H, Kaya M, Yamashita T. Efficacy of cementless total hip arthroplasty in patients on long-term hemodialysis. J Arthroplasty. 2005;20:66–71.

    PubMed  Google Scholar 

  45. Devlin VJ, Einhorn TA, Gordon SL, Alvarez EV, Butt KM. Total hip arthroplasty after renal transplantation. Long-term follow-up study and assessment of metabolic bone status.J Arthroplasty. 1988;3:205–13.

    CAS  PubMed  Google Scholar 

  46. Nowicki P, Chaudhary H. Total hip replacement in renal transplant patients. J Bone Joint Surg Br. 2007;89:1561–6.

    CAS  PubMed  Google Scholar 

  47. Shrader MW, Schall D, Parvizi J, McCarthy JT, Lewallen DG. Total hip arthroplasty in patients with renal failure: a comparison between transplant and dialysis patients. J Arthroplasty. 2006;21:324–9.

    PubMed  Google Scholar 

  48. Tannenbaum DA, Matthews LS, Grady-Benson JC. Infection around joint replacements in patients who have a renal or liver transplantation. J Bone Joint Surg Am. 1997;79:36–43.

    CAS  PubMed  Google Scholar 

  49. Radford PJ, Doran A, Greatorex RA, Rushton N. Total hip replacement in the renal transplant recipient. J Bone Joint Surg Br. 1989;71:456–9.

    CAS  PubMed  Google Scholar 

  50. Sakalkale DP, Hozack WJ, Rothman RH. Total hip arthroplasty in patients on long-term renal dialysis. J Arthroplasty. 1999;14:571–5.

    CAS  PubMed  Google Scholar 

  51. Lieberman JR, Fuchs MD, Haas SB, Garvin KL, Goldstock L, Gupta R, Pellicci PM, Salvati EA. Hip arthroplasty in patients with chronic renal failure. J Arthroplasty. 1995;10:191–5.

    CAS  PubMed  Google Scholar 

  52. Cheng EY, Klibanoff JE, Robinson HJ, Bradford DS. Total hip arthroplasty with cement after renal transplantation. Long-term results. J Bone Joint Surg Am. 1995;77:1535–42.

    CAS  PubMed  Google Scholar 

  53. Alpert B, Waddell JP, Morton J, Bear RA. Cementless total hip arthroplasty in renal transplant patients. Clin Orthop Relat Res. 1992;(284):164–9.

    Google Scholar 

  54. Orwin JF, Fisher RC, Wiedel JD. Use of the uncemented bipolar endoprosthesis for the treatment of steroid-induced osteonecrosis of the hip in renal transplantation patients. J Arthroplasty. 1991;6:1–9.

    CAS  PubMed  Google Scholar 

  55. Doran MF, Crowson CS, Pond GR, O’Fallon WM, Gabriel SE. Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum. 2002;46:2287–93.

    PubMed  Google Scholar 

  56. Bernatsky S, Hudson M, Suissa S. Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis. Rheumatology (Oxford). 2007;46:1157–60.

    CAS  Google Scholar 

  57. Schrama JC, Espehaug B, Hallan G, Engesaeter LB, Furnes O, Havelin LI, Fevang B-TS. Risk of revision for infection in primary total hip and knee arthroplasty in patients with rheumatoid arthritis compared with osteoarthritis: a prospective, population-based study on 108,786 hip and knee joint arthroplasties from the Norwegian Arthroplast. Arthritis Care Res (Hoboken). 2010;62:473–9.

    Google Scholar 

  58. Bozic KJ, Lau E, Kurtz S, Ong K, Rubash H, Vail TP, Berry DJ. Patient-related risk factors for periprosthetic joint infection and postoperative mortality following total hip arthroplasty in Medicare patients. J Bone Joint Surg Am. 2012;94:794–800.

    PubMed  Google Scholar 

  59. Bongartz T, Halligan CS, Osmon DR, Reinalda MS, Bamlet WR, Crowson CS, Hanssen AD, Matteson EL. Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. Arthritis Rheum. 2008;59:1713–20.

    PubMed Central  PubMed  Google Scholar 

  60. Berbari EF, Osmon DR, Duffy MCT, Harmssen RNW, Mandrekar JN, Hanssen AD, Steckelberg JM. Outcome of prosthetic joint infection in patients with rheumatoid arthritis: the impact of medical and surgical therapy in 200 episodes. Clin Infect Dis. 2006;42:216–23.

    PubMed  Google Scholar 

  61. Mont MA, Waldman BJ, Hungerford DS. Evaluation of preoperative cultures before second-stage reimplantation of a total knee prosthesis complicated by infection. A comparison-group study. J Bone Joint Surg Am. 2000;82-A:1552–7.

    CAS  PubMed  Google Scholar 

  62. Brook I. Secondary bacterial infections complicating skin lesions. J Med Microbiol. 2002;51:808–12.

    PubMed  Google Scholar 

  63. Tokarski AT, Blaha D, Mont MA, et al. Perioperative skin preparation. J Orthop Res. 2014;32 Suppl 1:S26–30.

    PubMed  Google Scholar 

  64. Bierbaum BE, Callaghan JJ, Galante JO, Rubash HE, Tooms RE, Welch RB. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am. 1999;81:2–10.

    CAS  PubMed  Google Scholar 

  65. Greenky M, Gandhi K, Pulido L, Restrepo C, Parvizi J. Preoperative anemia in total joint arthroplasty: is it associated with periprosthetic joint infection? Clin Orthop Relat Res. 2012;470(10):2695–701.

    PubMed Central  PubMed  Google Scholar 

  66. Keating EM, Ritter MA. Transfusion options in total joint arthroplasty. J Arthroplasty. 2002;17:125–8.

    PubMed  Google Scholar 

  67. Forgie MA, Wells PS, Laupacis A, Fergusson D. Preoperative autologous donation decreases allogeneic transfusion but increases exposure to all red blood cell transfusion: results of a meta-analysis. International Study of Perioperative Transfusion (ISPOT) investigators. Arch Intern Med. 1998;158:610–6.

    CAS  PubMed  Google Scholar 

  68. Goodnough LT. Risks of blood transfusion. Crit Care Med. 2003;31(12 Suppl):S678–86.

    PubMed  Google Scholar 

  69. Feagan BG, Wong CJ, Kirkley A, Johnston DW, Smith FC, Whitsitt P, Wheeler SL, Lau CY. Erythropoietin with iron supplementation to prevent allogeneic blood transfusion in total hip joint arthroplasty. A randomized, controlled trial. Ann Intern Med. 2000;133:845–54.

    CAS  PubMed  Google Scholar 

  70. World Health Organization (WHO). Nutrition. 2014. http://www.who.int/nutrition/pressnote_action_on_malnutrition/en/.

  71. Cross MB, Yi PH, Thomas CF, Garcia J, Della Valle CJ. Evaluation of malnutrition in orthopaedic surgery. J Am Acad Orthop Surg. 2014;22:193–9.

    PubMed  Google Scholar 

  72. Jaberi FM, Parvizi J, Haytmanek CT, Joshi A, Purtill J. Procrastination of wound drainage and malnutrition affect the outcome of joint arthroplasty. Clin Orthop Relat Res. 2008;466:1368–71.

    PubMed Central  PubMed  Google Scholar 

  73. Puskarich CL, Nelson CL, Nusbickel FR, Stroope HF. The use of two nutritional indicators in identifying long bone fracture patients who do and do not develop infections. J Orthop Res. 1990;8:799–803.

    CAS  PubMed  Google Scholar 

  74. Guo JJ, Yang H, Qian H, Huang L, Guo Z, Tang T. The effects of different nutritional measurements on delayed wound healing after hip fracture in the elderly. J Surg Res. 2010;159:503–8.

    CAS  PubMed  Google Scholar 

  75. Rai J, Gill SS, Kumar BRJS. The influence of preoperative nutritional status in wound healing after replacement arthroplasty. Orthopedics. 2002;25:417–21.

    PubMed  Google Scholar 

  76. Seibert DJ. Pathophysiology of surgical site infection in total hip arthroplasty. Am J Infect Control. 1999;27:536–42.

    CAS  PubMed  Google Scholar 

  77. Greene KA, Wilde AH, Stulberg BN. Preoperative nutritional status of total joint patients. Relationship to postoperative wound complications. J Arthroplasty. 1991;6:321–5.

    CAS  PubMed  Google Scholar 

  78. Batsis JA, Naessens JM, Keegan MT, Huddleston PM, Wagie AE, Huddleston JM. Body mass index and the impact on hospital resource use in patients undergoing total knee arthroplasty. J Arthroplasty. 2010;25:1250–7. e1.

    PubMed  Google Scholar 

  79. Namba RS, Paxton L, Fithian DC, Stone ML. Obesity and perioperative morbidity in total hip and total knee arthroplasty patients. J Arthroplasty. 2005;20:46–50.

    PubMed  Google Scholar 

  80. Malinzak RA, Ritter MA, Berend ME, Meding JB, Olberding EM, Davis KE. Morbidly obese, diabetic, younger, and unilateral joint arthroplasty patients have elevated total joint arthroplasty infection rates. J Arthroplasty. 2009;24:84–8.

    PubMed  Google Scholar 

  81. Inacio MCS, Kritz-Silverstein D, Raman R, Macera CA, Nichols JF, Shaffer RA, Fithian DC. The risk of surgical site infection and re-admission in obese patients undergoing total joint replacement who lose weight before surgery and keep it off post-operatively. Bone Joint J. 2014;96-B:629–35.

    CAS  PubMed  Google Scholar 

  82. Brogden RN, Peters DH. Teicoplanin. A reappraisal of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1994;47:823–54.

    CAS  PubMed  Google Scholar 

  83. Rybak MJ, Lomaestro BM, Rotschafer JC, Moellering RC, Craig WA, Billeter M, Dalovisio JR, Levine DP. Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. Clin Infect Dis. 2009;49:325–7.

    PubMed  Google Scholar 

  84. Traynor AM, Nafziger AN, Bertino JS. Aminoglycoside dosing weight correction factors for patients of various body sizes. Antimicrob Agents Chemother. 1995;39:545–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  85. Prokuski L. Prophylactic antibiotics in orthopaedic surgery. J Am Acad Orthop Surg. 2008;16:283–93.

    PubMed  Google Scholar 

  86. Forse RA, Karam B, MacLean LD, Christou NV. Antibiotic prophylaxis for surgery in morbidly obese patients. Surgery. 1989;106:750–6. discussion 756–757.

    CAS  PubMed  Google Scholar 

  87. Neu HC. Cephalosporin antibiotics as applied in surgery of bones and joints. Clin Orthop Relat Res. 1984;(190):50–64.

    Google Scholar 

  88. The American Academy of Orthopaedic Surgeons (AAOS). Recommendations for the use of intravenous antibiotic prophylaxis in primary total joint arthroplasty. 2013. http://www.aaos.org/about/papers/advistmt/1027.asp.

  89. Hansen E, Belden K, Silibovsky R, et al. Perioperative antibiotics. J Orthop Res. 2014;32 Suppl 1:S31–59.

    PubMed  Google Scholar 

  90. Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med. 1992;326:281–6.

    CAS  PubMed  Google Scholar 

  91. Weber WP, Marti WR, Zwahlen M, et al. The timing of surgical antimicrobial prophylaxis. Ann Surg. 2008;247:918–26.

    PubMed  Google Scholar 

  92. Steinberg JP, Braun BI, Hellinger WC, Kusek L, Bozikis MR, Bush AJ, Dellinger EP, Burke JP, Simmons B, Kritchevsky SB. Timing of antimicrobial prophylaxis and the risk of surgical site infections: results from the trial to reduce antimicrobial prophylaxis errors. Ann Surg. 2009;250:10–6.

    PubMed  Google Scholar 

  93. Cantoni L, Glauser MP, Bille J. Comparative efficacy of daptomycin, vancomycin, and cloxacillin for the treatment of Staphylococcus aureus endocarditis in rats and role of test conditions in this determination. Antimicrob Agents Chemother. 1990;34:2348–53.

    CAS  PubMed Central  PubMed  Google Scholar 

  94. Hawn MT, Richman JS, Vick CC, Deierhoi RJ, Graham LA, Henderson WG, Itani KMF. Timing of surgical antibiotic prophylaxis and the risk of surgical site infection. JAMA Surg. 2013;148:649–5796.

    PubMed  Google Scholar 

  95. Enzler MJ, Berbari E, Osmon DR. Antimicrobial prophylaxis in adults. Mayo Clin Proc. 2011;86:686–701.

    CAS  PubMed Central  PubMed  Google Scholar 

  96. Zanetti G, Giardina R, Platt R. Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery. Emerg Infect Dis. 2001;7:828–31.

    CAS  PubMed Central  PubMed  Google Scholar 

  97. Johnson AJ, Daley JA, Zywiel MG, Delanois RE, Mont MA. Preoperative chlorhexidine preparation and the incidence of surgical site infections after hip arthroplasty. J Arthroplasty. 2010;25:98–102.

    PubMed  Google Scholar 

  98. Wihlborg O. The effect of washing with chlorhexidine soap on wound infection rate in general surgery. A controlled clinical study. Ann Chir Gynaecol. 1987;76:263–5.

    CAS  PubMed  Google Scholar 

  99. Edmiston CE, Seabrook GR, Cambria RA, Brown KR, Lewis BD, Sommers JR, Krepel CJ, Wilson PJ, Sinski S, Towne JB. Molecular epidemiology of microbial contamination in the operating room environment: is there a risk for infection? Surgery. 2005;138:573–82.

    PubMed  Google Scholar 

  100. Persson M, van der Linden J. Wound ventilation with ultraclean air for prevention of direct airborne contamination during surgery. Infect Control Hosp Epidemiol. 2004;25:297–301.

    PubMed  Google Scholar 

  101. Malinzak RA, Ritter MA. Postoperative wound infection: 35 years of experience. Orthopedics. 2006;29:797–8.

    PubMed  Google Scholar 

  102. Brandt C, Hott U, Sohr D, Daschner F, Gastmeier P, Rüden H. Operating room ventilation with laminar airflow shows no protective effect on the surgical site infection rate in orthopedic and abdominal surgery. Ann Surg. 2008;248:695–700.

    PubMed  Google Scholar 

  103. Ritter MA, Olberding EM, Malinzak RA. Ultraviolet lighting during orthopaedic surgery and the rate of infection. J Bone Joint Surg Am. 2007;89:1935–40.

    PubMed  Google Scholar 

  104. Health Hazard Evaluation Report. HETA, Brigham and Women’s Hospital Boston, Massachusetts. May 2009. Available at: http://www.cdc.gov/niosh/hhe/reports/pdfs/2007-0257-3082.pdf.

  105. Sehulster L, Chinn RYW. Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep. 2003;52:1–42.

    PubMed  Google Scholar 

  106. Salassa TE, Swiontkowski MF. Surgical attire and the operating room: role in infection prevention. J Bone Joint Surg Am. 2014;96:1485–92.

    PubMed  Google Scholar 

  107. Evans RP. Current concepts for clean air and total joint arthroplasty: laminar airflow and ultraviolet radiation: a systematic review. Clin Orthop Relat Res. 2011;469:945–53.

    PubMed Central  PubMed  Google Scholar 

  108. Mangram AJA, Horan TTC, Pearson MML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control. 1999;27:97–132. quiz 133–4; discussion 96.

    CAS  PubMed  Google Scholar 

  109. Hooper GJ, Rothwell AG, Frampton C, Wyatt MC. Does the use of laminar flow and space suits reduce early deep infection after total hip and knee replacement? The ten-year results of the New Zealand Joint Registry. J Bone Joint Surg Br. 2011;93:85–90.

    CAS  PubMed  Google Scholar 

  110. Kapadia BH, Pivec R, Johnson AJ, Issa K, Naziri Q, Daley JA, Mont MA. Infection prevention methodologies for lower extremity total joint arthroplasty. Expert Rev Med Devices. 2013;10:215–24.

    CAS  PubMed  Google Scholar 

  111. Urquhart DM, Hanna FS, Brennan SL, Wluka AE, Leder K, Cameron PA, Graves SE, Cicuttini FM. Incidence and risk factors for deep surgical site infection after primary total hip arthroplasty: a systematic review. J Arthroplasty. 2010;25:1216–22. e1–e3.

    PubMed  Google Scholar 

  112. Manley M, Ong K, Lau E, Kurtz SM. Effect of volume on total hip arthroplasty revision rates in the United States Medicare population. J Bone Joint Surg Am. 2008;90:2446–51.

    PubMed  Google Scholar 

  113. Sciple GW, Riemensnider DK, Schleyer CA. Recovery of microorganisms shed by humans into a sterilized environment. Appl Microbiol. 1967;15:1388–92.

    CAS  PubMed Central  PubMed  Google Scholar 

  114. Andersson BM, Lidgren L, Schalén C, Steen A. Contamination of irrigation solutions in an operating theatre. Infect Control. 1984;5:339–41.

    CAS  PubMed  Google Scholar 

  115. Quraishi ZA, Blais FX, Sottile WS, Adler LM. Movement of personnel and wound contamination. AORN J. 1983. doi:10.1016/S0001-2092(07)69557-X.

    PubMed  Google Scholar 

  116. Tanner J, Norrie P, Melen K. Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev. 2011;(11):CD004122.

    Google Scholar 

  117. Alexander JW, Fischer JE, Boyajian M, Palmquist J, Morris MJ. The influence of hair-removal methods on wound infections. Arch Surg. 1983;118:347–52.

    CAS  PubMed  Google Scholar 

  118. Darouiche RO, Wall MJ, Itani KMF, et al. Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med. 2010;362:18–26.

    CAS  PubMed  Google Scholar 

  119. Swenson BR, Hedrick TL, Metzger R, Bonatti H, Pruett TL, Sawyer RG. Effects of preoperative skin preparation on postoperative wound infection rates: a prospective study of 3 skin preparation protocols. Infect Control Hosp Epidemiol. 2009;30:964–71.

    PubMed Central  PubMed  Google Scholar 

  120. Sistla SC, Prabhu G, Sistla S, Sadasivan J. Minimizing wound contamination in a “clean” surgery: comparison of chlorhexidine-ethanol and povidone-iodine. Chemotherapy. 2010;56:261–7.

    CAS  PubMed  Google Scholar 

  121. Dumville JC, McFarlane E, Edwards P, Lipp A, Holmes A. Preoperative skinantiseptics for preventing surgical wound infections after clean surgery. Cochrane Database Syst Rev. 2013;3:CD003949. doi:10.1002/14651858.

    PubMed  Google Scholar 

  122. Parker M, Gurusamy K, Azegami S. Arthroplasties (with and without bone cement) for proximal femoral fractures in adults. Cochrane Database Syst Rev. 2010;(2):CD001706.

    Google Scholar 

  123. Newman ET, Watters TS, Lewis JS, Jennings JM, Wellman SS, Attarian DE, Grant SA, Green CL, Vail TP, Bolognesi MP. Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty. J Bone Joint Surg Am. 2014;96:279–84.

    PubMed  Google Scholar 

  124. Friedman R, Homering M, Holberg G, Berkowitz SD. Allogeneic blood transfusions and postoperative infections after total hip or knee arthroplasty. J Bone Joint Surg Am. 2014;96:272–8.

    PubMed  Google Scholar 

  125. Parker MJ, Livingstone V, Clifton R, McKee A. Closed suction surgical wound drainage after orthopaedic surgery. Cochrane Database Syst Rev. 2007;(3):CD001825.

    Google Scholar 

  126. Fairclough JA, Johnson D, Mackie I. The prevention of wound contamination by skin organisms by the pre-operative application of an iodophor impregnated plastic adhesive drape. J Int Med Res. 1986;14:105–9.

    CAS  PubMed  Google Scholar 

  127. Chiu KY, Lau SK, Fung B, Ng KH, Chow SP. Plastic adhesive drapes and wound infection after hip fracture surgery. Aust N Z J Surg. 1993;63:798–801.

    CAS  PubMed  Google Scholar 

  128. Alexander JW, Aerni S, Plettner JP. Development of a safe and effective one-minute preoperative skin preparation. Arch Surg. 1985;120:1357–61.

    CAS  PubMed  Google Scholar 

  129. Dale H, Hallan G, Espehaug B, Havelin LI, Engesaeter LB. Increasing risk of revision due to deep infection after hip arthroplasty. Acta Orthop. 2009;80:639–45.

    PubMed Central  PubMed  Google Scholar 

  130. Dale H, Fenstad AM, Hallan G, et al. Increasing risk of prosthetic joint infection after total hip arthroplasty. Acta Orthop. 2012;83:449–58.

    PubMed Central  PubMed  Google Scholar 

  131. Robinson ANH, Drew S, Anderson J, Bentley G, Ridgway GL. Suction tip contamination in the ultraclean-air operating theatre. Ann R Coll Surg Engl. 1993;75:254–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  132. Strange-Vognsen HH, Klareskov B. Bacteriologic contamination of suction tips during hip arthroplasty. Acta Orthop Scand. 1988;59:410–1.

    CAS  PubMed  Google Scholar 

  133. Livesey C, Wylde V, Descamps S, Estela CM, Bannister GC, Learmonth ID, Blom AW. Skin closure after total hip replacement: a randomised controlled trial of skin adhesive versus surgical staples. J Bone Joint Surg Br. 2009;91:725–9.

    CAS  PubMed  Google Scholar 

  134. Ting NT, Moric MM, Della Valle CJ, Levine BR. Use of knotless suture for closure of total hip and knee arthroplasties. A prospective, randomized clinical trial. J Arthroplasty. 2012;27:1783–8.

    PubMed  Google Scholar 

  135. Smith EL, DiSegna ST, Shukla PY, Matzkin EG. Barbed versus traditional sutures: closure time, cost, and wound related outcomes in total joint arthroplasty. J Arthroplasty. 2014;29:283–7.

    PubMed  Google Scholar 

  136. Alijanipour P, Karam J, Llinás A, et al. Operative environment. J Orthop Res. 2014;32 Suppl 1:S60–80.

    PubMed  Google Scholar 

  137. Berbari EF, Osmon DR, Lahr B, Eckel-Passow JE, Tsaras G, Hanssen AD, Mabry T, Steckelberg J, Thompson R. The Mayo prosthetic joint infection risk score: implication for surgical site infection reporting and risk stratification. Infect Control Hosp Epidemiol. 2012;33:774–81.

    PubMed  Google Scholar 

  138. Ghanem E, Heppert V, Spangehl M, et al. Wound management. J Orthop Res. 2014;32 Suppl 1:S108–19.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Javad Parvizi MD, FRCS .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Parvizi, J., Küçükdurmaz, F. (2015). Hip Sepsis and the Prevention of Perioperative Infections. In: Aaron, R. (eds) Diagnosis and Management of Hip Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-19905-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-19905-4_12

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19904-7

  • Online ISBN: 978-3-319-19905-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics